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The construction of defective interfering rubella virus particles

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Summary.

 Two defective viral vectors containing nucleic acid sequences from rubella virus strains RJ and RS linked to the reporter gene luciferase have been constructed. The vector RNAs are shown to replicate and interfere with wild-type virus in co-infected cells. The interference is associated with a polymorphic nucleotide at nt34 in the 5′ stem-loop. The use of these constructs as expression vectors is discussed.

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Authors and Affiliations

  1. Department of Molecular Pathology, University College London, London, U.K., , , , , , GB

    G. Terry, P. Londesborough & L. Ho

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  1. G. Terry
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  2. P. Londesborough
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  3. L. Ho
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Accepted October 6, 1999

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Terry, G., Londesborough, P. & Ho, L. The construction of defective interfering rubella virus particles. Arch. Virol. 145, 625–633 (2000). https://doi.org/10.1007/s007050050051

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  • DOI: https://doi.org/10.1007/s007050050051

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