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Recent molecular evolution of hepatitis B virus genotype F in Latin America

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Abstract

The evolution of hepatitis B virus genotype F (HBV-F) in Latin America is not completely understood. The aim of this study was to evaluate the molecular evolution of HBV-F in Latin America by comparing 224 whole-genome sequences. Bayesian coalescent analysis was performed to estimate the time to the most recent common ancestor. Four main clades were found, dating from between 1245 and 1730. In addition, four subclades were identified, dating to between 1705 and 1801. The overall effective population size of HBV-F grew in the 18th century and showed an initial expansion outward from Venezuela to other countries from Latin America. Although HBV-F originated thousands of years ago, circulating strains of HBV-F appear to have spread in recent centuries, particularly in the 18th and 19th centuries. The new molecular data provide valuable information for characterizing the evolution of Native American HBV-F in recent centuries.

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Acknowledgments

We thank the Universidade Luterana do Brasil for technical support for the development and implementation of this study.

Funding

This work was funded by ULBRA, Simbios Biotecnologia and Research Support Foundation of the State of Rio Grande do Sul (FAPERGS, Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Grant: FAPERGS/MS/CNPq/SESRS n. 03/2017 – PPSUS). V.R. Lunge was also financially supported by the National Council for Scientific and Technological Development of Brazil (CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico; process numbers 313564/2014-0; 313304/2014-9). J.M. Wolf was further supported by the Coordination for the Improvement of Higher Education Personnel of Brazil (CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Finance Code 001).

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Authors and Affiliations

  1. Universidade Luterana do Brasil, ULBRA, Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde, Canoas, RS, Brazil

    Jonas Michel Wolf, Thiago Kastell Mazeto, Daniel Simon & Vagner Ricardo Lunge

  2. Laboratório de Diagnóstico Molecular, Universidade Luterana do Brasil, Canoas, RS, Brazil

    Jonas Michel Wolf, Vagner Reinaldo Zingalli Bueno Pereira & Vagner Ricardo Lunge

  3. Simbios Biotecnologia, Cachoeirinha, RS, Brazil

    Vagner Ricardo Lunge

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  1. Jonas Michel Wolf
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  2. Thiago Kastell Mazeto
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  3. Vagner Reinaldo Zingalli Bueno Pereira
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  4. Daniel Simon
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  5. Vagner Ricardo Lunge
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Contributions

JM Wolf, D Simon, and VR Lunge designed the study. JM Wolf and TK Mazeto performed the bioinformatics analyses. JM Wolf, TK Mazeto, D. Simon, and VR Lunge wrote the first draft of the manuscript and contributed to the literature review and discussion of results. All authors contributed to and approved the final manuscript.

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Correspondence to Jonas Michel Wolf.

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Wolf, J.M., Mazeto, T.K., Pereira, V.R.Z.B. et al. Recent molecular evolution of hepatitis B virus genotype F in Latin America. Arch Virol 167, 597–602 (2022). https://doi.org/10.1007/s00705-022-05376-z

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  • DOI: https://doi.org/10.1007/s00705-022-05376-z

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