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Emergence of a deviating genotype VI pigeon paramyxovirus type-1 isolated from India

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Abstract

Pigeon paramyxovirus type 1 (PPMV-1) is an antigenic variant of avian paramyxovirus type 1 (APMV-1), which infects pigeons. The virus causes high morbidity and mortality, creating an alarming state for the poultry industry. The present work describes the molecular and pathogenic characterization of a PPMV-1 strain isolated from pigeon in Bhopal, India. Complete genome sequence analysis revealed a genome of 15,192 nucleotides encoding six genes organized in the order 3’-N-P-M-F-HN-L-5’. The fusion gene sequence analysis showed the presence of multiple basic amino acids 112R-R-Q-K-R-F117 at the cleavage site corresponding to pathogenic strains. The mean death time and intracerebral pathogenicity index values indicated a mesogenic nature for the PPMV-1 isolate. On phylogenetic analysis, the strain clustered with genotype VI viruses, including isolates from pigeon and dove. The Bhopal strain showed significant intra and inter-genotype evolutionary distance, suggesting the emergence of a new sub-genotype, VIj.

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Acknowledgements

The avian paramyxovirus research in our laboratory is currently supported by the Department of Biotechnology, India (NER-BPMC/2013/134/AAB21).

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Authors and Affiliations

  1. Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India

    Ketan Ganar, Moushumee Das & Sachin Kumar

  2. National Institute of High Security Animal Diseases, OIE reference Lab on Avian Influenza, Bhopal, MP, 462022, India

    Ashwin Ashok Raut & Anamika Mishra

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  1. Ketan Ganar
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  2. Moushumee Das
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Correspondence to Sachin Kumar.

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Ganar, K., Das, M., Raut, A.A. et al. Emergence of a deviating genotype VI pigeon paramyxovirus type-1 isolated from India. Arch Virol 162, 2169–2174 (2017). https://doi.org/10.1007/s00705-017-3340-2

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