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A cluster of salivirus A1 (Picornaviridae) infections in newborn babies with acute gastroenteritis in a neonatal hospital unit in Hungary

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Abstract

Salivirus (family Picornaviridae) may be associated with acute gastroenteritis in humans, but there have been no reports of salivirus outbreaks. Salivirus A1 infection with faecal virus concentrations of 2.1-2.6 × 109/g were identified retrospectively in newborn babies, between the ages of 1.5 and 5 days, with apparent clinical symptoms of diarrhea (100 %), fever (40 %), vomiting (40 %), and loss of appetite (40 %) in a neonatal hospital unit in Hungary in July 2013. The complete genome sequence of the salivirus (including the 5′-terminal end) was determined. Salivirus mono-infection may be associated with gastroenteritis in babies who are a few days old. Salivirus testing should be done in public health laboratories in gastroenteritis outbreaks with unknown etiology.

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Acknowledgments

This work was financially supported by a grant from the Hungarian Scientific Research Fund (OTKA/NKFIH K111615). ÁB was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Science. Special thanks to Nick J. Knowles for proofreading the manuscript.

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Authors and Affiliations

  1. Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7, 7623, Pécs, Hungary

    Ákos Boros, Nóra Bolba, Péter Pankovics & Gábor Reuter

  2. University of Pécs, Pécs, Hungary

    Ákos Boros, Nóra Bolba, Péter Pankovics & Gábor Reuter

  3. Department of Epidemiology, ÁNTSZ Regional Institute of State Public Health Service, Kecskemét, Hungary

    Margit Raáb

  4. Department of Pediatrics, Neonatal Care Unit, Town Hospital of Baja, Baja, Hungary

    Éva Károly & Adrienn Karai

  5. Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, Szeged, Hungary

    Andrea Kátai

Authors
  1. Ákos Boros
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  2. Margit Raáb
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  3. Éva Károly
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  4. Adrienn Karai
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  5. Andrea Kátai
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  6. Nóra Bolba
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  7. Péter Pankovics
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  8. Gábor Reuter
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Correspondence to Gábor Reuter.

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Boros, Á., Raáb, M., Károly, É. et al. A cluster of salivirus A1 (Picornaviridae) infections in newborn babies with acute gastroenteritis in a neonatal hospital unit in Hungary. Arch Virol 161, 1671–1677 (2016). https://doi.org/10.1007/s00705-016-2824-9

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  • DOI: https://doi.org/10.1007/s00705-016-2824-9

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