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Assessment of infection with polyomaviruses BKV, JCV and SV40 in different groups of Cuban individuals

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Abstract

We investigated the frequency of BKV, JCV and SV40 reactivation in three groups of Cuban patients by multiplex nested PCR assay of 40 paraffin-embedded colorectal neoplasm tissues, 113 urine samples, and 125 plasma samples from 27 transplant recipients, and cerebrospinal fluid (CSF) from 67 HIV-1-infected individuals with central nervous system (CNS) disorders. None of these polyomaviruses were detected in colorectal neoplasms. JCV DNA was detected in 2 of 67 patients (2.9%) with CNS disorders, but neither BKV nor SV40 was identified. BKV was found in urine from 38.5% and 28.6% of adult and pediatric transplant recipients, respectively. In adult renal transplant recipients, excretion of BKV in urine was significantly associated with episodes of acute rejection (p=0.012) and with excretion of HCMV in urine (p= 0.008). In Cuba, the polyomaviruses studied here could not be related to colorectal neoplasms, and JCV was rarely detected in CSFs of HIV-1-infected individuals, whilst BKV reactivation was found to occur frequently in organ transplant recipients.

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Authors and Affiliations

  1. STD laboratory, Department of Virology, Institute of Tropical Medicine “Pedro Kourí”, Autopista Novia del Mediodía, Km 6 ½, La Lisa, Marianao 13, Po Box: 601, Havana City, Cuba

    Pedro A. Martínez, Vivian Kourí, Gustavo Cordero, Consuelo Correa, Yudira Soto, Yoan Alemán, Lissette Pérez & Alina Álvarez

  2. Institute of Gastroenterology, Havana, Cuba

    Licet González & Bienvenido Grá

  3. Pediatric Hospital “William Soler”, Havana, Cuba

    César Silvério, Norma Hondal, Mabel González & Iliana Alvarez

  4. Institute of Hematology and Immunology, Havana, Cuba

    Elvira Dorticós, Alberto Arencibia & Juan C. Jaime

  5. Pediatric Hospital of Centro Habana, Havana, Cuba

    José Florin, Lourdes Pérez, Diana P. Duran, Juan José Marchena, Luis Solar, Nancy Cazorla & Yardelys Pérez

  6. “Hermanos Ameijeiras” Hospital, Havana, Cuba

    Gregorio Petirena

  7. Clinical Department, Institute of Tropical Medicine “Pedro Kourí”, Autopista Novia del Mediodía, Km 6 ½, La Lisa, Marianao 13, Po Box: 601, Havana City, Cuba

    Virginia Capó

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  1. Pedro A. Martínez
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Correspondence to Pedro A. Martínez.

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Martínez, P.A., Kourí, V., Cordero, G. et al. Assessment of infection with polyomaviruses BKV, JCV and SV40 in different groups of Cuban individuals. Arch Virol 157, 315–321 (2012). https://doi.org/10.1007/s00705-011-1172-z

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  • DOI: https://doi.org/10.1007/s00705-011-1172-z

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