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Immunoglobulin G subclasses in antibody responses to St. Louis encephalitis virus infections

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Abstract

The aim of this study was to recognize the specific antiviral response patterns of IgG1, IgG2, IgG3 and IgG4 subclasses, elicited during St. Louis encephalitis virus (SLEV) infection in humans. Eighty-five samples of human sera from 44 patients with SLEV infection were obtained between days 1 and 365 or later, after onset of the disease. These samples were processed by immunofluorescence assay for detection of IgG1-, IgG2-, IgG3- and IgG4-specific antibodies. We demonstrate the presence of all isotypes of IgG for more than a year in patients infected with SLEV. However; isotype IgG1 was present at the highest titers, with a peak between days 8 and 30 after onset of the disease.

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Acknowledgments

We thank Dr. Adriana Gruppi for her constructive comments. This study was supported by grants from the Fondo para la Investigación Científica y Tecnológica (FONCYT 01-12572), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), and Secretaría de Ciencia y Técnica, Universidad Nacional de Córdoba, Argentina (SECyT).

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Authors and Affiliations

  1. Instituto de Virología “Dr. J.M. Vanella”, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

    Lorena Ivana Spinsanti, Adrián Alejandro Farías, Juan Javier Aguilar & Marta Silvia Contigiani

  2. Bioestadística, Escuela de Nutrición, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

    María del Pilar Díaz

  3. Instituto de Virología “Dr. J.M. Vanella”, Enfermera Gordillo Gómez s/n, Ciudad Universitaria, 5016, Córdoba, Argentina

    Lorena Ivana Spinsanti

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  1. Lorena Ivana Spinsanti
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  2. Adrián Alejandro Farías
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  3. Juan Javier Aguilar
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  4. María del Pilar Díaz
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  5. Marta Silvia Contigiani
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Correspondence to Lorena Ivana Spinsanti.

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Spinsanti, L.I., Farías, A.A., Aguilar, J.J. et al. Immunoglobulin G subclasses in antibody responses to St. Louis encephalitis virus infections. Arch Virol 156, 1861–1864 (2011). https://doi.org/10.1007/s00705-011-1047-3

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  • DOI: https://doi.org/10.1007/s00705-011-1047-3

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