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The human cytomegalovirus TRL11/IRL11-encoded FcγR binds differentially to allelic variants of immunoglobulin G1

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Abstract

Human cytomegalovirus (HCMV) has evolved several immune-evasion strategies. One strategy involves encoding Fcgamma receptor (FcγR)-like proteins that thwart the Fcγ-mediated effector functions. Our aim was to determine whether GM allotypes—immunoglobulin γ chain determinants expressed primarily on the Fc segment—modulate this viral strategy through differential binding to the viral FcγR. Results of our ELISA binding studies show that the mean absorbance values for binding to the HCMV TRL11/IRL11-encoded FcγR were higher for IgG1 expressing the GM 3 allotype than for those expressing the allelic GM 1,2,17 determinants (p = 0.0005), a finding with potential implications for genetic etiology of HCMV-associated diseases.

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Acknowledgements

This study was supported in part by a grant from the South Carolina Clinical & Translational Research Institute, NIH grant DK070877, and DoD grant W81XWH-08-1-0373.

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No conflicting financial interests exist.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC, 29425-2230, USA

    Aryan M. Namboodiri & Janardan P. Pandey

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  1. Aryan M. Namboodiri
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  2. Janardan P. Pandey
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Correspondence to Janardan P. Pandey.

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Namboodiri, A.M., Pandey, J.P. The human cytomegalovirus TRL11/IRL11-encoded FcγR binds differentially to allelic variants of immunoglobulin G1. Arch Virol 156, 907–910 (2011). https://doi.org/10.1007/s00705-011-0937-8

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  • DOI: https://doi.org/10.1007/s00705-011-0937-8

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