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Lack of alternative coreceptor use by pediatric HIV-1 R5 isolates for infection of primary cord or adult peripheral blood mononuclear cells

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Summary

HIV-1 infection of neonates results in an extended acute period of virus replication, frequent neurological problems and reduced survival compared to adults. In adults, R5 viruses mainly infect CCR5+ CD4+ memory T-cells. In neonates, CCR5+ memory T-cells form a substantially smaller fraction of total lymphocytes. We therefore tested whether alternative coreceptors confer infection of lymphocytes by pediatric isolates. Pediatric HIV-1 R5 isolates failed to replicate in Δ32/Δ32 CCR5 PBMCs or in cord PBMCs treated with a CCR5 inhibitor. These results do not indicate a role for alternative coreceptors and provide support for CCR5 inhibitors in the therapy of HIV-1+ neonates.

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Correspondence to P. R. Clapham.

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Correspondence: Paul R. Clapham, Program in Molecular Medicine, UMASS Medical School, 373 Plantation St, Biotech II Suite 315, Worcester, MA 01605, U.S.A.

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Sullivan, W., Dorr, P., Perros, M. et al. Lack of alternative coreceptor use by pediatric HIV-1 R5 isolates for infection of primary cord or adult peripheral blood mononuclear cells. Arch Virol 153, 363–366 (2008). https://doi.org/10.1007/s00705-007-1099-6

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  • DOI: https://doi.org/10.1007/s00705-007-1099-6

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