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Elevated levels of interleukin-2 receptor and intercellular adhesion molecule 1 in sera from a venezuelan cohort of patients with dengue

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Summary

This study evaluated the levels of soluble interleukin-2 receptor (sIL-2R) and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with dengue. Sera from 17 patients with dengue fever (DF), 15 with dengue hemorrhagic fever (DHF) and 12 healthy individuals were obtained. Increased levels of sIL-2R and sICAM-1 were found in patients with DF and DHF when compared to normal; those were not correlated with leukocytes, hepatic serum enzyme levels or haemostatic parameters. Levels of sIL-2R were related to the different grades of DHF. These results suggest that increased levels of sIL-2R and sICAM-1 are a common feature of dengue.

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Authors and Affiliations

  1. Seccion de Virologia, Facultad de Medicina, Instituto de Investigaciones Clinicas “Dr. Americo Negrette”, Universidad del Zulia, Zulia, Venezuela

    N. Valero, Y. Larreal, L. M. Espina, I. Reyes & M. Maldonado

  2. Seccion de Inmunologia y Biologia Celular, Facultad de Medicina, Instituto de Investigaciones Clinicas “Dr. Americo Negrette”, Universidad del Zulia, Zulia, Venezuela

    J. Mosquera

Authors
  1. N. Valero
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  2. Y. Larreal
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  3. L. M. Espina
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  4. I. Reyes
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  5. M. Maldonado
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  6. J. Mosquera
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Correspondence to N. Valero.

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Correspondence: Nereida Valero, MgSc, Apartado Postal 23, Maracaibo 4001-A, Zulia, Venezuela

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Valero, N., Larreal, Y., Espina, L. et al. Elevated levels of interleukin-2 receptor and intercellular adhesion molecule 1 in sera from a venezuelan cohort of patients with dengue. Arch Virol 153, 199–203 (2008). https://doi.org/10.1007/s00705-007-1080-4

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  • DOI: https://doi.org/10.1007/s00705-007-1080-4

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