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Association of CD14-260 (-159) C/T and Alzheimer’s disease: systematic review and trial sequential analyses

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

Current studies have evaluated the association between CD14-260 (also known as -159) C/T polymorphism and Alzheimer’s disease (AD) susceptibility. However, the association remains inconclusive. The aim of this study was to draw an accurate conclusion of the association. The literature search was conducted using PubMed, Embase, Chinese National Knowledge Infrastructure, China Biological Medicine Database, and Wanfang Databases for related articles. Four case–control studies with a total of 868 cases and 766 controls were eligible to be included in this meta-analysis. The association was evaluated by calculating the odds ratios (ORs) with the corresponding 95% confidence intervals (CIs). Overall, there was no significant association between CD14-260C/T polymorphism and AD risk in all genetic models (the allele model T vs. C: OR = 1.06, 95% CI 0.92–1.21, p = 0.44; the homozygous model TT vs. CC: OR = 1.09, 95% CI 0.83–1.44, p = 0.53; the heterozygote model CT vs. CC: OR = 0.95, 95% CI 0.75–1.22, p = 0.71; the dominant model TT + CT vs. CC: OR = 1.05, 95% CI 0.84–1.32, p = 0.66; the recessive model TT vs. CT + CC: OR = 1.14, 95% CI 0.92–1.43, p = 0.24). The sample size of 5064 was calculated by applying trial sequential analysis. Cumulative z curve does not cross trial sequential monitoring boundary. In conclusion, the present meta-analysis suggests that the CD14-260C/T polymorphism may not be associated with genetic susceptibility of AD, but the association remains indeterminate due to the insufficient evidence.

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Acknowledgements

This study was supported by Grants from the National Natural Science Foundation of China (nos. 30973162; 81302738).

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Authors and Affiliations

  1. Department of Pharmacy, Guangdong Province Hospital of Integrated Traditional Chinese and Western Medicine, Foshan, 528200, China

    Yan Wang & Xiaoling Wu

  2. Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China

    Xun Deng, Yanjiao Ma & Yong Wang

  3. Departments of Human Biology (Neuroscience), University of Toronto, Toronto, M5S 1A1, Canada

    Siyi Huang

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  1. Yan Wang
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  2. Xiaoling Wu
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  3. Xun Deng
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  4. Yanjiao Ma
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  5. Siyi Huang
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Correspondence to Yong Wang.

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Wang, Y., Wu, X., Deng, X. et al. Association of CD14-260 (-159) C/T and Alzheimer’s disease: systematic review and trial sequential analyses. J Neural Transm 125, 1313–1318 (2018). https://doi.org/10.1007/s00702-018-1896-y

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  • DOI: https://doi.org/10.1007/s00702-018-1896-y

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