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Inflammation processes in perinatal brain damage

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Abstract

Once viewed as an isolated, immune-privileged organ, the central nervous system has undergone a conceptual change. Neuroinflammation has moved into the focus of research work regarding pathomechanisms underlying perinatal brain damage. In this review, we provide an overview of current concepts regarding perinatal brain damage and the role of inflammation in the disease pathomechanism.

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Acknowledgments

Our research work is supported by Inserm, Université Paris 7, PremUP, the Sixth Framework Program of the European Commission, the Fondation des Gueules Cassées, the Fondation Motrice, the ELA Foundation, the Fondation Grace de Monaco, the Institut pour la Recherche sur la Moelle épinière et l’Encéphale (IRME), the Medical Research Council, the Charité, the German Research Foundation (DFG), the German Federal Ministry of Education and Research, the Sonnenfeld Stiftung and the Sanitätsrat Dr.-Emil-Alexander-Huebner-und-Gemahlin-Stiftung.

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Authors and Affiliations

  1. Hôpital Robert Debré, Inserm, U676, 48 Blvd Serurier, 75019, Paris, France

    Vincent Degos, Géraldine Favrais, Angela M. Kaindl, Stéphane Peineau, Anne Marie Guerrot, Catherine Verney & Pierre Gressens

  2. Faculté de Médecine Denis-Diderot, Université Paris 7, Paris, France

    Vincent Degos, Géraldine Favrais, Angela M. Kaindl, Stéphane Peineau, Anne Marie Guerrot, Catherine Verney & Pierre Gressens

  3. PremUP, Paris, France

    Vincent Degos, Géraldine Favrais, Angela M. Kaindl, Stéphane Peineau, Anne Marie Guerrot, Catherine Verney & Pierre Gressens

  4. Réanimation Pédiatrique et Néonatologie, Hôpital Clocheville, CHRU Tours, Université François Rabelais, 37000, Tours, France

    Géraldine Favrais

  5. Pediatric Neurology, Charité, Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany

    Angela M. Kaindl

  6. Institute of Cell Biology and Neurobiology, Center for Anatomy, Charité, Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany

    Angela M. Kaindl

  7. MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical, Sciences, University Walk, Bristol, BS8 1TD, UK

    Stéphane Peineau

  8. Institute for Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, London, UK

    Pierre Gressens

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  1. Vincent Degos
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  2. Géraldine Favrais
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  3. Angela M. Kaindl
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  7. Pierre Gressens
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Correspondence to Pierre Gressens.

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Degos, V., Favrais, G., Kaindl, A.M. et al. Inflammation processes in perinatal brain damage. J Neural Transm 117, 1009–1017 (2010). https://doi.org/10.1007/s00702-010-0411-x

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  • DOI: https://doi.org/10.1007/s00702-010-0411-x

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