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Chemical architecture of the posterior striatum in the human brain

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Summary.

The neurochemical organization of the posterior caudate nucleus (CN) (body, gyrus and tail) and putamen (Put) was analyzed in the human brain using adjacent sections stained for acetylcholinesterase (AChE), limbic system-associated membrane protein (LAMP), enkephalin (ENK), parvalbumin (PV), calbindin (CB) and tyrosine hydroxylase (TH). Striosomes were visualized in all striatal regions but the anterior two thirds of the CN tail. They were highly immunoreactive (-ir) for ENK and LAMP, devoid of PV and AChE staining, and surrounded by a ring of tissue with pale TH- and CB-ir neuropil. In the Put, other rings of tissue completely free of ENK labeling surrounded certain striosomes (clear septa). In the CN body, gyrus and tail some markers revealed gradients and heterogeneities along the dorsoventral and mediolateral axes. A rim of striatal tissue densely stained for ENK and LAMP and poorly labeled for PV was noticeable along the lateral edge of the Put and the dorsolateral sector of the CN body. Our results illustrate a chemical architecture in the posterior striatum that is heterogeneous and slightly different from that found in the more anterior striatum.

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Abbreviations

AChE:

acetylcholinesterase

CB:

calbindin

CN:

caudate nucleus

ENK:

enkephalin

ir:

immunoreactive

LAMP:

limbic system-associated membrane protein

PB:

phosphate buffer

PBS:

phosphate buffer saline

Put:

putamen

PV:

parvalbumin

TH:

tyrosine hydroxylase

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  1. Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain

    J. Bernácer, L. Prensa & J. M. Giménez-Amaya

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  1. J. Bernácer
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  2. L. Prensa
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  3. J. M. Giménez-Amaya
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Correspondence to J. M. Giménez-Amaya.

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Correspondence: José Manuel Giménez-Amaya, Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, Despacho A-39, 28029 Madrid, Spain

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Bernácer, J., Prensa, L. & Giménez-Amaya, J. Chemical architecture of the posterior striatum in the human brain. J Neural Transm 115, 67–75 (2008). https://doi.org/10.1007/s00702-007-0803-8

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