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Effect of spirulina maxima on the haloperidol induced tardive dyskinesia and oxidative stress in rats

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Summary

Haloperidol is a widely used neuroleptic drug for the treatment of acute and chronic psychosis. The use of haloperidol is limited by extrapyramidal movement disorders such as Parkinsonism, akathesia, dystonia, and tardive dyskinesia (TD). Treatment with haloperidol increases oxyradicals which are implicated in TD. Spirulina is widely used as nutritional supplement rich in proteins and antioxidants. The present study is proposed to study the effect of spirulina on haloperidol induced TD and oxidative stress by studying TD, various enzymatic and nonenzymatic antioxidants and lipid peroxidation. Haloperidol 1 mg/kg/i.p was used to induce vacuous chewing movements in rats. Spirulina maxima suspended in 1% between 80 at a dose of 45, 90 and 180 mg/kg were administered by gavage along with haloperidol from 21st day to 49th day of treatment. Spirulina supplementation at a dose of 180 mg/kg significantly improved enzymatic and nonenzymatic antioxidants and decreased the tardive dyskinesia induced by haloperidol. In conclusion, the results of present investigation suggest that spirulina decreases haloperidol induced oxidative stress and TD by many mechanisms as it is cocktail of antioxidants. On chronic use it may inhibit haloperidol induced reduced expression of DNA thereby increases the expression of enzymatic and nonenzymatic antioxidants and protects against oxidative stress induced neurodegeneration and TD.

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References

  • LA Adler E Paselow J Rotrosen E Duncan M Lee M Rosenthal B Angrist (1993a) ArticleTitleVitamin E treatment of tardive dyskinesia Am J Psychiatry 150 1405–1407 Occurrence Handle1:STN:280:DyaK3szls1anuw%3D%3D

    CAS  Google Scholar 

  • LA Adler E Paselow J Rotrosen E Duncan M Rosenthal B Angrist (1993b) ArticleTitleVitamin E in tardive dyskinesia: Time course of effect placebo substitution Psychopharmacol Bull 29 371–374 Occurrence Handle1:STN:280:DyaK2c7mslCgtA%3D%3D

    CAS  Google Scholar 

  • LA Adler R Edson P Lavori E Peselow E Duncan M Rosenthal J Rotrosen (1998) ArticleTitleLong term effects of vitamin E for tardive dyskinesia Biol Psychiatry 43 868–872 Occurrence Handle1:CAS:528:DyaK1cXktVCms7s%3D Occurrence Handle9627740

    CAS  PubMed  Google Scholar 

  • LA Adler J Rotrosen R Edson P Lavori J Lohr R Hitzemnn D Raisch M Caligiuri K Tracy (1999) ArticleTitleVitamin E for tardive dyskinesia Arch Gen Psychiatry 56 836–841 Occurrence Handle1:CAS:528:DyaK1MXmt1WlsLY%3D Occurrence Handle12892048

    CAS  PubMed  Google Scholar 

  • PS Amanpreet Singh Naidu SK Kulkarni (2003) ArticleTitlePossible antioxidant and neuroprotective mechanisms of FK 506 in attenuating haloperidol-induced orofacial dyskinesia Eur J Pharmacol 477 87–94

    Google Scholar 

  • OA Andreassen HA Jorgensen (1994) ArticleTitleM1 ganglioside attenuates the development of vacuous chewing movements induced by long term haloperidol treatment of rats Psychopharmacology 116 517–522 Occurrence Handle1:CAS:528:DyaK2MXivVGnur8%3D Occurrence Handle7701057

    CAS  PubMed  Google Scholar 

  • OA Andreassen HA Jorgensen (1995) ArticleTitleThe rat model of tardive dyskinesia: relationship between vacuous chewing movements and gross motor activity during acute and long term haloperidol treatment Life Sci 57 2263–2272 Occurrence Handle1:CAS:528:DyaK2MXptFGrtr0%3D Occurrence Handle7475980

    CAS  PubMed  Google Scholar 

  • OA Andreassen TO Aamo HA Jorgensen (1996) ArticleTitleInhibition by memantine of the development of persistent oral dyskinesias induced by long term haloperidol treatment of rats Br J Pharmacol 119 751–757 Occurrence Handle1:CAS:528:DyaK28Xmtl2rt7w%3D Occurrence Handle8904651

    CAS  PubMed  Google Scholar 

  • InstitutionalAuthorNameAPA Press, American Psychiatric Association (1992) Tardive dyskinesia: a task force report of the American Psychiatric Association APA Press Washington DC

    Google Scholar 

  • Y Barak M Swartz E Shamir D Stein A Weizman (1998) ArticleTitleVitamin E in the treatment of tardive dyskinesia: a statistical meta-analysis Ann Clin Psychiatry 10 101–105 Occurrence Handle1:STN:280:DyaK1cvlt1OgsA%3D%3D Occurrence Handle9781472

    CAS  PubMed  Google Scholar 

  • EW Becker B Jakover D Luft RM Schmuelling (1986) ArticleTitleClinical and biochemical evaluations of the alga Spirulina with regard to its application in the treatment of obesity: a double-blind cross-over study Nutr Rep Int 33 565–574

    Google Scholar 

  • RF Beers IW Sizer (1952) ArticleTitleA spectrometric method for measuring the breakdown hydrogen peroxide by catalase J Biol Chem 195 133–140 Occurrence Handle1:CAS:528:DyaG38Xjt12juw%3D%3D Occurrence Handle14938361

    CAS  PubMed  Google Scholar 

  • A Belay (1993) ArticleTitleCurrent knowledge on potential health benefits of Spirulina J Appl Phycol 5 235–241

    Google Scholar 

  • P Ben-Amotz (1997) Presentation of poly saccharides from micro-algae workshop Duke University, Durham North California, U.S.A.

    Google Scholar 

  • VB Bhat KM Madyastha (2000) ArticleTitleC-phycocyanin: a potent peroxyl radical scavenger in vivo and invitro Biochem Biophys Res Com 275 20–25 Occurrence Handle1:CAS:528:DC%2BD3cXls1Cnt7c%3D Occurrence Handle10944434

    CAS  PubMed  Google Scholar 

  • VB Bhat KM Madyastha (2001) ArticleTitleScavenging of peroxynitrite by phycocyanin and phycocyanobilin from Spirulina plantensis: protection against oxidative damage to DNA Biochem Biophys Res Commun 285 262–266 Occurrence Handle1:CAS:528:DC%2BD3MXkvFOqsLo%3D Occurrence Handle11444835

    CAS  PubMed  Google Scholar 

  • PC Bickford T Gould L Briederick K Chadman A Pollock D Young B Shukitt-Hale J Josesph (2000) ArticleTitleAntioxidant-rich diets improve cerebellar physiology and motor learning in aged rats Brain Res 866 211–217 Occurrence Handle1:CAS:528:DC%2BD3cXjsVGisL8%3D Occurrence Handle10825496

    CAS  PubMed  Google Scholar 

  • MS Blios (1958) ArticleTitleAntioxidant determination by the use of stable free radical Nature 26 1199

    Google Scholar 

  • PC Burcham (1998) ArticleTitleGenotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogeneous and role in formation of endogenous DNA adducts Mutagenesis 13 287–305 Occurrence Handle1:CAS:528:DyaK1cXjs1Knurk%3D Occurrence Handle9643589

    CAS  PubMed  Google Scholar 

  • JL Cadet JB Lohr DV Jeste (1986) ArticleTitleFree radicals and tardive dyskinesia Trends Neurosci 9 107–108 Occurrence Handle1:CAS:528:DyaL28Xit1artrs%3D

    CAS  Google Scholar 

  • JL Cadet JB Lohr (1989) ArticleTitlePossible involvement of free radicals in neuroleptic-induced movement disorders Ann NY Acad Sci 570 176–185 Occurrence Handle1:STN:280:DyaK3c7ps1ylsQ%3D%3D Occurrence Handle2576510

    CAS  PubMed  Google Scholar 

  • DE Casey (1985) ArticleTitleSpontaneous and Tardive dyskinesias: clinical and laboratory studies J Clin Psychiatry 46 42–47 Occurrence Handle1:STN:280:DyaL2M7lslCrtA%3D%3D Occurrence Handle2858480

    CAS  PubMed  Google Scholar 

  • YC Chen SC Shen WR Lee WC Hou LL Yang TJ Lee (2001) ArticleTitleInhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclo oxygenase-2 gene expression by rutin, quercetin and quercetin penta acetate in RAW 264.7 macrophages J Cell Biochem 82 537–548 Occurrence Handle1:CAS:528:DC%2BD3MXlvFKrtr8%3D Occurrence Handle11500931

    CAS  PubMed  Google Scholar 

  • JT Coyle P Putfarcken (1993) ArticleTitleOxidative stress, glutamate and neurodegenerative disorders Science 262 689–695 Occurrence Handle1:CAS:528:DyaK2cXlvVek Occurrence Handle7901908

    CAS  PubMed  Google Scholar 

  • I Creese DR Burt SH Snyder (1976) ArticleTitleDopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs Science 192 481–483 Occurrence Handle1:CAS:528:DyaE28XktFemur0%3D Occurrence Handle3854

    CAS  PubMed  Google Scholar 

  • K De Keyser (1991) ArticleTitleExcitotoxic mechanisms may be involved in the pathophysiology of tardive dyskinesia Clin Neuropharmacol 14 562–565 Occurrence Handle1:STN:280:DyaK387islGmuw%3D%3D Occurrence Handle1837757

    CAS  PubMed  Google Scholar 

  • HH Draper M Haley (1990) ArticleTitleMalondialdehyde determination as an index of lipid peroxidation Methods Enzymol 186 421–431 Occurrence Handle1:CAS:528:DyaK3MXksVGhtLo%3D Occurrence Handle2233309

    CAS  PubMed  Google Scholar 

  • C Duval M Poelman (1994) ArticleTitleScavenger effect of vitamin E and derivatives on free radicals generated by photo irradiated phenomelanin J Pharm Sci 84 107–110

    Google Scholar 

  • MT Egan TM Hyde GW Albers A Elkashef RC Alexander A Reeve A Blum RE Saez RJ Wyatt (1992) ArticleTitleTreatment of tardive dyskinesia with vitamin E Am J Psychiatry 149 773–777 Occurrence Handle1:STN:280:DyaK383nt1ehtg%3D%3D Occurrence Handle1350428

    CAS  PubMed  Google Scholar 

  • MF Egan TM Hyde JE Kleinman RJ Wyatt (1995) ArticleTitleNeuroleptic-induced vacuous chewing movements in rodents: incidence and effects of long term increases in haloperidol dose Psychopharmacology 117 74–81 Occurrence Handle1:CAS:528:DyaK2MXkslSis7s%3D Occurrence Handle7724705

    CAS  PubMed  Google Scholar 

  • AM Elkashef PE Ruskin N Bacher D Barett (1990) ArticleTitleVitamin E in the treatment of tardive dyskinesia Am J Psychiatry 147 505–506 Occurrence Handle1:STN:280:DyaK3c7ps1erug%3D%3D Occurrence Handle1969247

    CAS  PubMed  Google Scholar 

  • AM Elkashef RJ Wyatt (1999) ArticleTitleTardive dyskinesia: possible involvement of free radical and treatment with vitamin E Schizophr Bull 25 731–740 Occurrence Handle1:STN:280:DC%2BD3c7ivFajtw%3D%3D Occurrence Handle10667743

    CAS  PubMed  Google Scholar 

  • GL Ellman (1959) ArticleTitleTissue sulfhydryl groups Arch Biochem Biophys 82 70–77 Occurrence Handle1:CAS:528:DyaG1MXotl2ksA%3D%3D Occurrence Handle13650640

    CAS  PubMed  Google Scholar 

  • H Esterbauer RJ Schaur H Zollner (1991) ArticleTitleChemistry and biochemistry of 4-hydroxyalkenal, malondialdehyde and related aldehydes Free Radic Biol Med 11 81–128 Occurrence Handle1:CAS:528:DyaK3MXmsFSnsbo%3D Occurrence Handle1937131

    CAS  PubMed  Google Scholar 

  • CF Foote RW Denny (1968) ArticleTitleChemistry of singlet oxygen. VII. Quenching by b-carotene J Am Chem Soc 90 6233–6235 Occurrence Handle1:CAS:528:DyaF1MXpsVWj

    CAS  Google Scholar 

  • CF Foote YC Chang RW Denny (1970) ArticleTitleChemistry of singlet oxygen. X. Carotenoids quenching parallels biological protection J Am Chem Soc 92 5216–5219 Occurrence Handle1:CAS:528:DyaE3MXpslWr Occurrence Handle5432666

    CAS  PubMed  Google Scholar 

  • C Gemma MH Mesches B Sepesi K Choo DB Holmes PC Bickford (2002) ArticleTitleDiet enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar-adrenergic function and increases in proinflammatory cytokines J Neurosci 22 6114–6120 Occurrence Handle1:CAS:528:DC%2BD38XlsFOjtro%3D Occurrence Handle12122072

    CAS  PubMed  Google Scholar 

  • H Gerster (1993) ArticleTitleAnticarcinogenic effect of common carotenoids Int J Vit Nut Res 63 93–121 Occurrence Handle1:CAS:528:DyaK2cXivFOhtr4%3D

    CAS  Google Scholar 

  • WM Glazer HO Morgenstern N Schooler CS Berkman DC Moore (1990) ArticleTitlePredictors of improvement in tardive dyskinesia following discontinuation of neuroleptic medication Br J Psychiatry 157 585–592 Occurrence Handle1:STN:280:DyaK38%2FjtlKktw%3D%3D Occurrence Handle1983390

    CAS  PubMed  Google Scholar 

  • R Gonzalez S Rodriguez C Romay A Gonzalez J Armesto D Remirez N Merino (1999) ArticleTitleAnti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats Pharmacol Res 39 1055–1059 Occurrence Handle10079148

    PubMed  Google Scholar 

  • S Gupta D Monsik DW Black S Berry PS Masand (1999) ArticleTitleTardive dyskinesia; review of treatments past, present, and future Ann Clin Psychiatry 11 257–266 Occurrence Handle1:STN:280:DC%2BD3c%2FmtFymtg%3D%3D Occurrence Handle10596740

    CAS  PubMed  Google Scholar 

  • B Halliwell JMC Gutteridge (1989) Free radicals in biology and medicine EditionNumber2 Clarendon Press Oxford

    Google Scholar 

  • R Henrikson (1989) Earth food spirulina Cited from Recolina Limited, Ronore Enterprises Inc. Launa Beach, CA 27–65

    Google Scholar 

  • T Hirata M Tanaki M Ooike T Tsunomura M Sagakuchi (2000) ArticleTitleAntioxidant activities of phycocyanobillin prepared from Spirulina platensis J Appl Phycol 12 435–439 Occurrence Handle1:CAS:528:DC%2BD3cXoslejtbg%3D

    CAS  Google Scholar 

  • TM Hyde MF Egan LL Wing RJ Wyatt DR Weinberger JE Kleinman (1995) ArticleTitlePersistent catalepsy associated with severe dyskinesias in rats treated with chronic injections of haloperidol decanoate Psychopharmacology (Berl) 118 142–149 Occurrence Handle1:CAS:528:DyaK2MXlt1ygs7k%3D

    CAS  Google Scholar 

  • K Iwata T Inayama T Kato (1987) ArticleTitleEffects of Spirulina platensis on fructose induced hyperlipidemia in rats J Jpn Soc Nutr Food Sci 40 463–467

    Google Scholar 

  • DV Jeste SG Potkin S Sinha S Feder RJ Wyatt (1979) ArticleTitleTardive dyskinesia-reversible and persistent Arch Gen Psychiatry 36 585–590 Occurrence Handle1:STN:280:DyaE1M7msVyhtw%3D%3D Occurrence Handle35116

    CAS  PubMed  Google Scholar 

  • JM Kane (1995) Tardive dyskinesia: epidemiology and clinical presentation FE Bloom DJ Kupfer (Eds) Psychopharmacology: The Fourth Generation of Progress NumberInSeries39 Raven Press New York 1485–1495

    Google Scholar 

  • JN Keller MP Mattson (1998) ArticleTitleRoles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction and death in the nervous system Rev NeuroSci 9 105–116 Occurrence Handle1:STN:280:DyaK1cznsFOhsg%3D%3D Occurrence Handle9711902

    CAS  PubMed  Google Scholar 

  • NI Krinsky SM Deneke (1982) ArticleTitleInteraction of oxygen and oxyradicals with carotenoids J Natl Can Inst 69 205–210 Occurrence Handle1:CAS:528:DyaL38XlsVSjsbg%3D

    CAS  Google Scholar 

  • AP Kulkarni JZ Byczkowski (1994) Introduction to biochemical toxicology EditionNumber2 Appleton and Lange Connecticut 103–105

    Google Scholar 

  • MH Lee RD Lin LY Shen YY Yang KY Yen WC Hou (2001) ArticleTitleMonoamino oxidase B and free radical scavenging activities of natural flavonoids in melastoma candidum D Don J Argic Food Chem 49 5551–5555 Occurrence Handle1:CAS:528:DC%2BD3MXnsVygur8%3D

    CAS  Google Scholar 

  • DN Liberman I Mody (1994) ArticleTitleRegulation of NMDA channel function by endogeneous Ca2+ dependent phosphatase Nature 369 235–239

    Google Scholar 

  • L Liu B Guo J Ruan X Dai L Chen B Wu (1991) ArticleTitleStudy on effect and mechanism of polysaccharides of Spirulina platensis on body immune functions improvement Marine Sci 6 44–49 Occurrence Handle1:CAS:528:DyaK38Xit1ahs7Y%3D

    CAS  Google Scholar 

  • JB Lohr JL Cadet MA Lohr DV Jeste RJ Wyatt (1987) ArticleTitleAlpha-tocopherol in tardive dyskinesia Lancet 1 913–914 Occurrence Handle1:STN:280:DyaL2s7ntFyrsg%3D%3D Occurrence Handle2882306

    CAS  PubMed  Google Scholar 

  • JB Lohr R Kuczenski HS Bracha M Moir DV Joste (1990) ArticleTitleIncreased indices of free radical activity in cerebrospinal fluid of patients with tardive dyskinesia Biol Psychiatry 28 533–539

    Google Scholar 

  • AS Luxia S Monica C Ornella B Plizzala R Laura B Livia M Anio P Ennio (1996) ArticleTitleEffect of b-carotene on cell cycle progression of human fibroblasts Mutagen 17 2395–2401

    Google Scholar 

  • SP Mahadik S Gowda (1996) ArticleTitleAntioxidants in the treatment of schizophrenia Drugs Today 32 553–565 Occurrence Handle1:CAS:528:DyaK2sXmtVChsA%3D%3D

    CAS  Google Scholar 

  • SP Mahadik RE Scheffer (1996) ArticleTitleOxidative injury and potential use of antioxidants of schizophrenia Prostagland Leukotri Essent Fatty Acids 55 45–54 Occurrence Handle1:CAS:528:DyaK28XmtFGis7c%3D

    CAS  Google Scholar 

  • SP Mahadik V Sitasawad M Mulchandani (1999) Membrane peroxidation and the neuropathology of schizophrenia M Peet I Glen DF Horrobin (Eds) Phospholipids spectrum disorders in psychiatry Marius Press Lancashire 99–111

    Google Scholar 

  • SP Mahadik D Evans H Lal (2001) ArticleTitleOxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in schizophrenia Progress Neuropsychopharmacol Biol Psych 25 463–493 Occurrence Handle1:CAS:528:DC%2BD3MXjsFSnsb4%3D

    CAS  Google Scholar 

  • TK Mao De Van J Water ME Gershwin (2000) ArticleTitleEffect of spirulina on the secretion of cytokines from peripheral blood mononuclear cells J Med Food 3 135–140 Occurrence Handle1:CAS:528:DC%2BD3cXovFGgu7c%3D Occurrence Handle19281334

    CAS  PubMed  Google Scholar 

  • WB Mathew R Sankranarayana P Nair C Varghese T Somanathan P Amma N Amma M Nair (1995) ArticleTitleEvaluation of chemoprevention of oral cancer with spirulina fusiformis Nutr Cancer 24 197–202 Occurrence Handle1:STN:280:DyaK287hslaluw%3D%3D Occurrence Handle8584455

    CAS  PubMed  Google Scholar 

  • MS Miranda RG Cintra SM Barros J Macini-Fitho (1998) ArticleTitleAntioxidant activity of the microalga spirulina maxima Braz Med Biol Res 31 1075–1079 Occurrence Handle1:CAS:528:DyaK1cXlvFyhu7w%3D

    CAS  Google Scholar 

  • HP Misra J Fridovich (1977) ArticleTitleSuperoxide dismutase: a photochemical augmentation assay Arch Biochem Biophys 181 308–312 Occurrence Handle1:CAS:528:DyaE2sXktFOku74%3D Occurrence Handle18108

    CAS  PubMed  Google Scholar 

  • B Moghaddam BS Bunney (1993) ArticleTitleDepolarization inactivation of dopamine neurons: terminal release characteristics Synapse 14 195–200 Occurrence Handle1:CAS:528:DyaK3sXmsVWktbw%3D Occurrence Handle8105547

    CAS  PubMed  Google Scholar 

  • PS Naidu SK Kulkarni (2001a) ArticleTitleExcitatory mechanisms in neuroleptic-induced vacuous chewing movements (VCMs): possible involvement of calcium and nitric oxide Behav Pharmacol 12 209 Occurrence Handle1:CAS:528:DC%2BD3MXltlKju7s%3D

    CAS  Google Scholar 

  • PS Naidu SK Kulkarni (2001b) ArticleTitlePossible involvement of prostaglandins in haloperidol-induced orofacial dyskinesia in rats Eur J Pharmacol 430 295–298 Occurrence Handle1:CAS:528:DC%2BD3MXot1Oks74%3D

    CAS  Google Scholar 

  • PS Naidu A Singh SK Kulkarni (2002) ArticleTitleCarvedilol attenuates neuroleptic- induced orofacial dyskinesia: possible antioxidant mechanisms Br J Pharmacol 136 193–200 Occurrence Handle1:CAS:528:DC%2BD38XktlGns7g%3D Occurrence Handle12010767

    CAS  PubMed  Google Scholar 

  • PS Naidu A Singh SK Kulkarni (2003) ArticleTitleQuercetin, a bioflavonoid, attenuates haloperidol-induced orofacial dyskinesia Neuropharmacology 44 1100–1106 Occurrence Handle1:CAS:528:DC%2BD3sXjvFeksb0%3D Occurrence Handle12763102

    CAS  PubMed  Google Scholar 

  • WG Nichans D Samuelson (1959) ArticleTitleFormation of malondialdehyde from phospholipids arachidonate during microsomal lipid peroxidation Eur J Biochem 6 126–130

    Google Scholar 

  • EB Nielson M Lyon (1978) ArticleTitleEvidence for cell loss in corpus striatum after long term treatment with a neuroleptic drug (flupenthixol) in rats Psychopharmacology 59 85–89

    Google Scholar 

  • NOAEL U.S. Food and Drug Administration. Guidance for Industry Reviewer’s. Estimating the safe starting dose in clinical trials for therapeutics and adult healthy volunteers. NOAEL no observed adverse effect level. The highest dose tested in an animal species without adverse effects detected. www.fda.gov/cber/gdlns/dose.htm (accessed on 1-11-2005)

  • ST Omaye TP Turbull HC Sauberchich (1979) ArticleTitleSelected methods for determination of ascorbic acid in cells, tissues and fluids Methods Enzymol 6 3–11 10.1016/0076-6879(79)62181-X

    Google Scholar 

  • HS Pall AC Williams DR Blake J Lunec (1987) ArticleTitleEvidence of enhanced lipid peroxidation in the cerebrospinal fluid of patients taking phenothiazines Lancet 2 596–599 Occurrence Handle1:STN:280:DyaL2szhsVSgsg%3D%3D Occurrence Handle2887888

    CAS  PubMed  Google Scholar 

  • JL Parada G De Caire MC De Mule MM Deno Cano (1998) ArticleTitleLactic acid bacteria growth promoters from spirulina platensis Int J Food Microbiol 45 225–228 Occurrence Handle1:STN:280:DyaK1M7isVWqsg%3D%3D Occurrence Handle9927000

    CAS  PubMed  Google Scholar 

  • V Parikh M Mohammad Khan P Sahebarao Mahadik (2003) ArticleTitleDifferential effects of antipsychotics on expression of antioxidant enzymes and membrane lipid peroxidation in rat brain J Psych Res 37 43–51

    Google Scholar 

  • M Peet J Langharne N Rangarajan GP Reynolds (1993) ArticleTitleTardive dyskinesia, lipid peroxidation and sustained amelioration with vitamin E treatment Int Clin Psychopharmacol 8 151–153 Occurrence Handle1:STN:280:DyaK2c%2Fos12nsg%3D%3D Occurrence Handle8263312

    CAS  PubMed  Google Scholar 

  • GW Prescott (1978) How to know the fresh water algae? EditionNumber3 W.C. Brown Iowa

    Google Scholar 

  • GM Raso R Meli R Di Carlo (2001) ArticleTitleInhibition of inducible nitric oxide synthase and cyalooxygenase expression by flavonoids in macrophage J773A.I Life Sci 12 921–931

    Google Scholar 

  • V Ravindranath DJ Reed (1990) ArticleTitleGlutathione depletion and formation of glutathione protein mixed disulfide following exposure of brain mitochondria to oxidative stress Biochem Biophys Res Commun 169 150–158

    Google Scholar 

  • R Reddy JK Yao (1996) ArticleTitleFree radical pathology in schizophrenia: a review Prostagland Leukotr Essent Fatty Acids 55 33–43 Occurrence Handle1:CAS:528:DyaK28XmtFGis7Y%3D

    CAS  Google Scholar 

  • D Remirez R Gonzalez N Merino S Rodriguez O Ancheta (2002) ArticleTitleInhibitory effects of spirulina in zymosan-induced arthritis in mice Mediators Inflamm 11 75–79 Occurrence Handle1:CAS:528:DC%2BD38Xks1yjt7k%3D Occurrence Handle12061427

    CAS  PubMed  Google Scholar 

  • V Rimbau A Camins CI Romay R Gonzalez M Pallas (1999) ArticleTitleProtective effect of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus Neurosci Lett 276 75–78 Occurrence Handle1:CAS:528:DyaK1MXntlemurw%3D Occurrence Handle10624795

    CAS  PubMed  Google Scholar 

  • C Romay J Armesto D Remirez R Gonzalez N Ledon I Garcia (1998) ArticleTitleAntioxidant and anti-inflammatory properties of C-phycocyanin from blue–green algae Inflamm Res 47 36–41 Occurrence Handle1:CAS:528:DyaK1cXosl2msg%3D%3D Occurrence Handle9495584

    CAS  PubMed  Google Scholar 

  • C Romay R Gonzalez (2000) ArticleTitlePhycocyanin is an antioxidant protector of human erythrocytes against lysis by peroxyl radicals J Pharm Pharmacol 52 367–368 Occurrence Handle1:CAS:528:DC%2BD3cXjtFWls7g%3D Occurrence Handle10813544

    CAS  PubMed  Google Scholar 

  • P Sachdev T Saharov S Cathcart (1999) ArticleTitleThe preventive role of antioxidants (selegiline and vitamin E) in a rat model of tardive dyskinesia Biol Psychiatry 46 1672–1681 Occurrence Handle1:CAS:528:DC%2BD3cXnvF2h Occurrence Handle10624549

    CAS  PubMed  Google Scholar 

  • Y Sagara (1998) ArticleTitleInduction of reactive oxygen species in neurons by haloperidol J Neurochem 71 1001–1012

    Google Scholar 

  • H Sasaki K Hashimoto Y Maeda T Inada Y Kitao S Fukui M Iyo (1995) ArticleTitleRolipram, a selective c-AMP phosphodiesterase inhibitor suppresses oro-facial dyskinetic movements in rats Life Sci 56 443–447

    Google Scholar 

  • P Scapicchio P Decina S Mukherjee G Caracci (1991) ArticleTitleEffects of α-tocopherol on persistent tardive dyskinesia in elderly schizophrenic patients Ital J Psych Behav Sci 1 111–114

    Google Scholar 

  • RE See AM Lynch (1995) ArticleTitleChronic haloperidol potentiates stimulated glutamate release in caudate putamen, but not prefrontal cortex Neuroreport 6 1795–1798 Occurrence Handle1:CAS:528:DyaK2MXovVajsr8%3D Occurrence Handle8541484

    CAS  PubMed  Google Scholar 

  • CV Seshadri BV Umesh R Manoharan (1991) ArticleTitleβ-Carotene studies in spirulina Bioresource Tech 38 111–113 Occurrence Handle1:CAS:528:DyaK38XitFehu78%3D

    CAS  Google Scholar 

  • E Shamir Y Barak I Plopsky N Zisapel A Elizur A Weizman (2000) ArticleTitleIs melatonin treatment effective for tardive dyskinesia? J Clin Psychiatry 61 556–558 Occurrence Handle1:CAS:528:DC%2BD3cXmvVemtr4%3D Occurrence Handle10982197

    CAS  PubMed  Google Scholar 

  • E Shamir Y Barak I Shalman M Laudon N Zisapel (2001) ArticleTitleMelatonin treatment for tardive dyskinesia Arch Gen Psychiatry 58 1049–1052 Occurrence Handle1:CAS:528:DC%2BD3MXptVemsrs%3D Occurrence Handle11695951

    CAS  PubMed  Google Scholar 

  • J Sharkey SP Butcher (1994) ArticleTitleImmunophillins mediate the neuroprotective effects of FK506 in focal cerebral ischemia Nature 371 336–339 Occurrence Handle1:CAS:528:DyaK2cXmt1Wgu7Y%3D Occurrence Handle7522303

    CAS  PubMed  Google Scholar 

  • S Shimamatsu (1989) Cited from RECON Recon Limited, A rainbow of colourful pigments Bangalore 13–14

    Google Scholar 

  • O Shirakawa CA Tamminga (1994) ArticleTitleBasal ganglia GABA and dopamine D1 binding site correlates of haloperidol-induced oral dyskinesias in rat Exp Neurol 127 62–69 Occurrence Handle1:CAS:528:DyaK2cXlvFGltrw%3D Occurrence Handle8200438

    CAS  PubMed  Google Scholar 

  • BR Shivakumar V Ravindranath (1993) ArticleTitleOxidative stress and thiol modification induced by chronic administration of haloperidol J Pharmacol Exp Ther 265 1137–1141 Occurrence Handle1:CAS:528:DyaK3sXltVyru78%3D Occurrence Handle8509999

    CAS  PubMed  Google Scholar 

  • KV Soares JJ McGranth (2000) ArticleTitleVitamin E for neuroleptic — induced tardive dyskinesia Cochrane Database System Rev 2 CD000209

    Google Scholar 

  • B Subramaniam H Rollema T Woolf NG Castagnoli (1990) ArticleTitleIdentification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats Biochem Biophys Res Commun 166 238–244

    Google Scholar 

  • k Sugioka Y Shimosegawa M Nakano (1987) ArticleTitleEstrogens as natural antioxidants of membrane phospholipids peroxidation FEBS Lett 210 37–39 Occurrence Handle1:CAS:528:DyaL2sXnvFSjsg%3D%3D Occurrence Handle3803578

    CAS  PubMed  Google Scholar 

  • Y Takai Y Hossayamada T Kato (1991) ArticleTitleEffect of water soluble and water insoluble fractions of spirulina over serum lipids and glucose resistance of rats J Jpn Soc Nutr Food Sci 44 273–277

    Google Scholar 

  • PF Von Voigtlander MA Burian JS Althaus LR Willams (1990) ArticleTitleEffects of chronic haloperidol on vitamin E levels and monoamine metabolism in rats fed normal and vitamin E deficient diets Res Commun Chem Pathol Pharmacol 68 343–352 Occurrence Handle1:CAS:528:DyaK3cXkvFWgsLc%3D

    CAS  Google Scholar 

  • BK Yamamoto MA Cooperman (1994) ArticleTitleDifferential effects of chronic antipsychotic drug treatment on extra cellular glutamate and dopamine concentrations J Neurosci 14 4159–4166 Occurrence Handle1:CAS:528:DyaK2cXlvFGlsLk%3D Occurrence Handle7913120

    CAS  PubMed  Google Scholar 

  • JK Yao R Reddy LG Elhinny DP Vankammen (1998) ArticleTitleEffects of haloperidol on antioxidant defense system enzymes in schizophrenia J Psychiatric Res 32 385–391 Occurrence Handle1:STN:280:DyaK1M%2FlvFSrug%3D%3D

    CAS  Google Scholar 

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  1. Department of Pharmacology, School of Pharmaceutical Sciences, Sri Padmavathi Mahila Viswa Vidyalayam, Chitoor Dist, Tirupati, Andhra Pradesh, India

    S. R. Thaakur & B. Jyothi

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  1. S. R. Thaakur
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  2. B. Jyothi
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Thaakur, S., Jyothi, B. Effect of spirulina maxima on the haloperidol induced tardive dyskinesia and oxidative stress in rats. J Neural Transm 114, 1217–1225 (2007). https://doi.org/10.1007/s00702-007-0744-2

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  • DOI: https://doi.org/10.1007/s00702-007-0744-2

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