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Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients

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Summary

This study aims to identify the effects of antipsychotics on plasma proteins, and on the proteins associated with schizophrenia. We applied proteomics technology to screen protein aberrations in Sprague-Dawley rats treated with antipsychotics and schizophrenic patients undergoing medication. ApoA-I was found significantly increased in the chlorpromazine-treated rats and decreased in the patients with treatment-resistant schizophrenia, which suggest that decreased levels of apoA-I might be associated with the pathology of schizophrenia and that chlorpromazine increases apoA-I levels as part of its therapeutic action.

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Abbreviations

ApoA-I:

Apolipoprotein A-I

ApoA-IV:

Apolipoprotein A-IV

ApoE:

Apolipoprotein E

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Authors and Affiliations

  1. Bio-X Center, Shanghai Jiao Tong University, Shanghai, P.R. China

    Y. J. La, C. L. Wan, H. Zhu, Y. F. Yang, Y. S. Chen, Y. X. Pan, G. Y. Feng & L. He

  2. Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

    Y. J. La, C. L. Wan, H. Zhu, Y. F. Yang, Y. S. Chen, Y. X. Pan, G. Y. Feng & L. He

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  1. Y. J. La
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  2. C. L. Wan
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  3. H. Zhu
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  4. Y. F. Yang
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  5. Y. S. Chen
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  6. Y. X. Pan
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  7. G. Y. Feng
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  8. L. He
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First two authors contributed equally.

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La, Y., Wan, C., Zhu, H. et al. Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients. J Neural Transm 114, 657–663 (2007). https://doi.org/10.1007/s00702-006-0607-2

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  • DOI: https://doi.org/10.1007/s00702-006-0607-2

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