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Rgs 2 gene polymorphisms as modulators of anxiety in humans?

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Summary.

Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02–0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3′ end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.

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Authors and Affiliations

  1. Laboratory of Molecular Psychiatry, Department of Psychiatry, University of Münster, Münster, Germany

    A. Leygraf, C. Hohoff & J. Deckert

  2. Department of Child & Adolescent Psychiatry, University of Saarland, Saarland, Germany

    C. Freitag

  3. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    S. A. G. Willis-Owen & J. Flint

  4. Institute of Transfusion Medicine, University of Münster, Münster, Germany

    P. Krakowitzky

  5. Department of Psychiatry, University of Frankfurt, Frankfurt, Germany

    J. Fritze

  6. Department of Psychiatry, University of Bonn, Bonn, Germany

    P. Franke

  7. Department of Psychiatry, University of Götttingen, Götttingen, Germany

    B. Bandelow

  8. Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany

    R. Fimmers

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  1. A. Leygraf
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  2. C. Hohoff
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  3. C. Freitag
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  4. S. A. G. Willis-Owen
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  5. P. Krakowitzky
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  6. J. Fritze
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  7. P. Franke
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  8. B. Bandelow
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  9. R. Fimmers
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  10. J. Flint
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  11. J. Deckert
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Leygraf, A., Hohoff, C., Freitag, C. et al. Rgs 2 gene polymorphisms as modulators of anxiety in humans?. J Neural Transm 113, 1921–1925 (2006). https://doi.org/10.1007/s00702-006-0484-8

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  • DOI: https://doi.org/10.1007/s00702-006-0484-8

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