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Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents

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Serotonin transporter promoter polymorphism (5-HTTLPR) genotype was previously found associated with substance use disorders, particularly in the subjects with comorbid antisocial behavior, and with temperament and personality traits at risk for substance abuse. Aim of the present study was to evaluate the possible association between 5-HTTLPR genotype and the availability to experiment illegal drugs among adolescents, in relationship with psychological characteristics. 216 caucasian high school students (aged 14–19 ys), 125 abstinent subjects, who have never experimented psychotropic drugs, and 91 experimenters of illegal drugs have been genotyped. Aggressiveness levels and temperamental traits were measured in both abstinent subjects and experimenters utilizing respectively Buss-Durkee-Hostility-Inventory (BDHI) and Cloninger Three-dimensional Personality Questionnaire (TPQ). Data about school performance have been also collected. The short-short (SS) genotype frequency was significantly higher among experimenters compared with abstinent subjects (p = 0.001). The odds ratio for the SS genotype vs the long-long (LL) genotype frequency was 4.67, 95% Cl (1.97–11.04), when experimenters were compared with abstinent students. The SS genotype frequency was significantly higher among aggressive/novelty seeker (NS) experimenters with poor school achievements, compared with drugs experimenters without aggressiveness and school failure (p = 0.02). When evaluated on the entire sample, BDHI mean total scores, NS scores at TPQ and school failure frequency were significantly higher in SS individuals, in comparison with LL subjects. Our data suggest that a decreased expression of the gene encoding the 5-HTT transporter, due to “S” promoter polymorphism, may be associated with an increased availability to experiment illegal drugs among adolescents, particularly in the subjects with more consistent aggressiveness, NS temperament and learning disabilities.

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References

  • Aghajanian GK (1978) Feedback regulation of central monoaminergic nuerons: evidence from single cell recording studies. In: Youdim MBH, Lovenberg W, Shaman DF, Lagnado TR (eds) Essays in neurochemistry and neuropharmacology, vol 3. Wiley and Sons, New York, pp 1–33

  • J Auerbach V Geller S Lezer E Shinwell RH Belmaker J Levine R Ebstein (1999) ArticleTitleDopamine D4 receptor (D4DR) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants. Mol Psychiatry 4 IssueID4 369–373 Occurrence Handle10.1038/sj.mp.4000531 Occurrence Handle10483054

    Article  PubMed  Google Scholar 

  • JG Auerbach M Faroy R Ebstein M Kahana J Levine (2001) ArticleTitleThe association of the dopamine D4 receptor gene (DRD4) and the serotonin transporter promoter gene (5-HTTLPR) with temperament in 12-month-old infants. J Child Psychol Psychiatry 42 IssueID6 777–783 Occurrence Handle10.1111/1469-7610.00774 Occurrence Handle11583250

    Article  PubMed  Google Scholar 

  • J Benjamin Y Osher M Kotler I Gritsenko L Nemanov RH Belmaker RP Ebstein (2000) ArticleTitleAssociation between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT). Mol Psychiatry 5 IssueID1 96–100 Occurrence Handle10.1038/sj.mp.4000640 Occurrence Handle10673775

    Article  PubMed  Google Scholar 

  • P Blier C de Montigny Y Chaput (1987) ArticleTitleModifications of the serotonin system by antidepressant treatments: implications for the therapeutic response in major depression. J Clin Psychopharmacol 7 IssueID[Suppl 6] 24S–35S Occurrence Handle3323264

    PubMed  Google Scholar 

  • Blum K, Braverman ER, Holder JM, Lubar JF, Monastra VJ, Miller D, Lubar JO, Chen TJ, Comings DE (2000) Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. J Psychoact Drugs 32[Suppl]: i–iv, 1–112

  • AH Buss A Durkee (1957) ArticleTitleAn inventory for assessing different kinds of hostility. J Consult Psychol 21 343–349 Occurrence Handle13463189

    PubMed  Google Scholar 

  • RJ Cadoret D Langbehn K Caspers EP Troughton R Yucuis HK Sandhu R Philibert (2003) ArticleTitleAssociations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Compr Psychiatry 44 IssueID2 88–101 Occurrence Handle10.1053/comp.2003.50018 Occurrence Handle12658617

    Article  PubMed  Google Scholar 

  • A Caspi D Begg N Dickson H Harrington J Langley TE Moffitt PA Silva (1997) ArticleTitlePersonality differences predict health-risk behaviors in young adulthood: evidence from a longitudinal study. J Pers Soc Psychol 73 IssueID5 1052–1063 Occurrence Handle10.1037/0022-3514.73.5.1052 Occurrence Handle9364760

    Article  PubMed  Google Scholar 

  • Castrogiovanni P, Maremmani I, Di Muro A (1993) Aggressive behaviour and hostility in depression: clinical aspects. In: Placidi GF, Dell’Osso L, Nisticò G, Akiskal HS (eds) Recurrent mood disorders. Springer, Berlin Heidelberg New York, pp 51–65

  • CR Cloninger (1987) ArticleTitleA systematic method for clinical description and classification of personality variants. Arch Gen Psychiatry 44 573–588 Occurrence Handle3579504

    PubMed  Google Scholar 

  • EF Coccaro RJ Kavoussi YI Sheline JD Lish JG Csernansky (1996) ArticleTitleImpulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Arch Gen Psychiatry 53 IssueID6 531–536 Occurrence Handle8639036

    PubMed  Google Scholar 

  • MA Diego TM Field CE Sanders (2003) ArticleTitleAcademic performance, popularity, and depression predict adolescent substance use. Adolescence 38 IssueID149 35–42 Occurrence Handle12803452

    PubMed  Google Scholar 

  • RP Ebstein L Nemanov I Klotz I Gritsenko RH Belmaker (1997) ArticleTitleAdditional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking. Mol Psychiatry 2 IssueID6 472–477 Occurrence Handle10.1038/sj.mp.4000333 Occurrence Handle9399690

    Article  PubMed  Google Scholar 

  • Fava M, Guaraldi GB, Mazzi F, Rigatelli M (1993) Intervista Clinica Strutturata per il DSM-III-R. Organizzazioni Speciali, Florence

  • G Gerra G Fertonani P Tagliavini A Zaimovic R Delsignore D Maestri P Avanzini R Caccavari F Brambilla (1995) ArticleTitleSerotonin function in detoxified heroin abusers: prolactin and cortisol responses to fenfluramine challenge. Psychiatry Res 58 153–160 Occurrence Handle10.1016/0165-1781(95)02665-J Occurrence Handle8570767

    Article  PubMed  Google Scholar 

  • Gerra G, Zaimovic A, Rizzi O, Timpano M, Zambelli U, Ventimiglia C (1999) Substance abuse among high-school students: relationship with social coping and temperament. Bull Narcot UNDCP LI (1–2): 75–96

  • G Gerra A Zaimovic U Zambelli R Delsignore MC Baroni G Laviola T Macchia F Brambilla (2000) ArticleTitleNeuroendocrine correlates of depression in abstinent heroin-dependent subjects. Psychiatry Res 96 221–234 Occurrence Handle10.1016/S0165-1781(00)00192-X Occurrence Handle11084218

    Article  PubMed  Google Scholar 

  • G Gerra L Angioni A Zaimovic G Moi M Bussandri S Bertacca G Santoro S Gardini R Caccavari MA Nicoli (2004) ArticleTitleSubstance use among high-school students: relationship with temperament, personality traits and parental care perception. Subst Use Misuse 39 333–355 Occurrence Handle10.1081/JA-120028493

    Article  Google Scholar 

  • G Gerra L Garofano G Santoro S Bosari C Pellegrini A Zaimovic G Moi M Bussandri A Moi F Brambilla C Donnini (2004) ArticleTitleAssociation between low activity serotonin transporter genotype and heroin dependence: behavioral and personality correlates. Am J Med Genet (Neuropsychiatr Genet) 126B 37–42 Occurrence Handle10.1002/ajmg.b.20111

    Article  Google Scholar 

  • R Gomez A Gomez L DeMello R Tallent (2001) ArticleTitlePerceived maternal control and support: effects on hostile biased social information processing and aggression among clinic-referred children with high aggression. J Child Psychol Psychiatry 42 IssueID4 513–522 Occurrence Handle10.1017/S0021963001007168 Occurrence Handle11383967

    Article  PubMed  Google Scholar 

  • BD Greenberg Q Li FR Lucas S Hu LA Sirota J Benjamin KP Lesch D Hamer DL Murphy (2000) ArticleTitleAssociation between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 96 IssueID2 202–216 Occurrence Handle10.1002/(SICI)1096-8628(20000403)96:2<202::AID-AJMG16>3.0.CO;2-J Occurrence Handle10893498

    Article  PubMed  Google Scholar 

  • T Hallikainen T Saito HM Lachman J Volavka T Pohjalainen OP Ryynanen J Kauhanen E Syvalahti J Hietala J Tiihonen (1999) ArticleTitleAssociation between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Mol Psychiatry 4 IssueID4 385–388 Occurrence Handle10.1038/sj.mp.4000526 Occurrence Handle10483057

    Article  PubMed  Google Scholar 

  • DH Hamer BD Greenberg SZ Sabol DL Murphy (1999) ArticleTitleRole of the serotonin transporter gene in temperament and character. J Personal Disord 13 IssueID4 312–327 Occurrence Handle10633313

    PubMed  Google Scholar 

  • Z Hawi M Dring A Kirley D Foley L Kent N Craddock P Asherson S Curran A Gould S Richards D Lawson H Pay D Turic K Langley M Owen M O’Donovan A Thapar M Fitzgerald M Gill (2002) ArticleTitleSerotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Mol Psychiatry 7 IssueID7 718–725 Occurrence Handle10.1038/sj.mp.4001048 Occurrence Handle12192616

    Article  PubMed  Google Scholar 

  • A Heils A Teufel S Petri M Seemann D Bengel U Balling P Riederer KP Lesch (1995) ArticleTitleFunctional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm 102 247–254 Occurrence Handle10.1007/BF01281159

    Article  Google Scholar 

  • Hibell B, Andersson B, Ahlström S, Balakireva O, Bjarnasson T, Kokkevi A, Morgan M (2000) The 1999 ESPAD Report The European School Survey on Alcohol and Other Drugs: Alcohol and other drug use among students in 30 european countries. CAN, Council of Europe, Stockholm

  • S Hu CL Brody C Fisher L Gunzerath ML Nelson SZ Sabol LA Sirota SE Marcus BD Greenberg DL Murphy DH Hamer (2000) ArticleTitleInteraction between the serotonin transporter gene and neuroticism in cigarette smoking behavior. Mol Psychiatry 5 IssueID2 181–188 Occurrence Handle10.1038/sj.mp.4000690 Occurrence Handle10822346

    Article  PubMed  Google Scholar 

  • YY Huang MA Oquendo JM Friedman LL Greenhill B Brodsky KM Malone V Khait JJ Mann (2003) ArticleTitleSubstance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. Neuropsychopharmacology 28 IssueID1 163–169 Occurrence Handle10.1038/sj.npp.1300000 Occurrence Handle12496953

    Article  PubMed  Google Scholar 

  • T Jacobsen M Huss M Fendrich MJ Kruesi U Ziegenhain (1997) ArticleTitleChildren’s ability to delay gratification: longitudinal relations to mother-child attachment. J Genet Psychol 158 IssueID4 411–426 Occurrence Handle9423273

    PubMed  Google Scholar 

  • U Kailash S Hedau V Gopalkrishna S Katiyar BC Das (2002) ArticleTitleA simple ‘paper smear’ method for dry collection, transport and storage of cervical cytological specimens for rapid screening of HPV infection by PCR. J Med Microbiol 51 IssueID7 606–610 Occurrence Handle12132779

    PubMed  Google Scholar 

  • H Kunugi M Hattori T Kato M Tatsumi T Sakai T Sasaki T Hirose S Nanko (1997) ArticleTitleSerotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry 2 457–462 Occurrence Handle10.1038/sj.mp.4000334 Occurrence Handle9399688

    Article  PubMed  Google Scholar 

  • K Lakatos Z Nemoda E Birkas Z Ronai E Kovacs K Ney I Toth M Sasvari-Szekely J Gervai (2003) ArticleTitleAssociation of D4 dopamine receptor gene and serotonin transporter promoter polymorphisms with infants’ response to novelty. Mol Psychiatry 8 IssueID1 90–97 Occurrence Handle10.1038/sj.mp.4001212 Occurrence Handle12556912

    Article  PubMed  Google Scholar 

  • KP Lesch D Bengel A Heils SZ Sabol BD Greenberg S Petri J Benjamin CR Muller DH Hamer DL Murphy (1996) ArticleTitleAssociation of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 1527–1531 Occurrence Handle10.1126/science.274.5292.1527 Occurrence Handle8929413

    Article  PubMed  Google Scholar 

  • EE Maccoby (2000) ArticleTitleParenting and its effects on children: on reading and misreading behavior genetics. Annu Rev Psychol 51 1–27 Occurrence Handle10.1146/annurev.psych.51.1.1 Occurrence Handle10751963

    Article  PubMed  Google Scholar 

  • SB Manuck JD Flory RE Ferrell KM Dent JJ Mann MF Muldoon (1999) ArticleTitleAggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry 45 IssueID5 603–614 Occurrence Handle10.1016/S0006-3223(98)00375-8 Occurrence Handle10088047

    Article  PubMed  Google Scholar 

  • RR McCrae PT Costa SuffixJr (1992) ArticleTitleDiscriminant validity of NEO-PI-R facet scales. Educ Psychol Measurement 52 229–237

    Google Scholar 

  • W Mischel Y Shoda PK Peake (1988) ArticleTitleThe nature of adolescent competencies predicted by preschool delay of gratification. J Pers Soc Psychol 54 IssueID4 687–696 Occurrence Handle10.1037/0022-3514.54.4.687 Occurrence Handle3367285

    Article  PubMed  Google Scholar 

  • W Mischel Y Shoda MI Rodriguez (1989) ArticleTitleDelay of gratification in children. Science 26, 244 IssueID4907 933–938

    Google Scholar 

  • TE Moffitt (1993) ArticleTitleAdolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychol Rev 100 IssueID4 674–701 Occurrence Handle10.1037/0033-295X.100.4.674 Occurrence Handle8255953

    Article  PubMed  Google Scholar 

  • F Murakami T Shimomura K Kotani S Ikawa E Nanba K Adachi (1999) ArticleTitleAnxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese. J Hum Genet 44 15–17 Occurrence Handle10.1007/s100380050098 Occurrence Handle9929970

    Article  PubMed  Google Scholar 

  • J Nightingale RM Williams (2000) ArticleTitleAttitudes to emotional expression and personality in predicting post-traumatic stress disorder. Br J Clin Psychol 39 IssueIDPt 3 243–254 Occurrence Handle10.1348/014466500163266 Occurrence Handle11033747

    Article  PubMed  Google Scholar 

  • TG O’Connor K Deater-Deckard D Fulker M Rutter R Plomin (1998) ArticleTitleGenotype-environment correlations in late childhood and early adolescence: antisocial behavioral problems and coercive parenting. Dev Psychol 34 IssueID5 970–981 Occurrence Handle10.1037/0012-1649.34.5.970 Occurrence Handle9779743

    Article  PubMed  Google Scholar 

  • K Ohara M Nagai Y Suzuki M Ochiai (1998) ArticleTitleAssociation between anxiety disorders and a functional polymorphism in the serotonin transporter gene. Psychiatry Res 81 277–279 Occurrence Handle10.1016/S0165-1781(98)00100-0 Occurrence Handle9858044

    Article  PubMed  Google Scholar 

  • AA Patkar WH Berrettini M Hoehe CC Thornton E Gottheil K Hill SP Weinstein (2002) ArticleTitleSerotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals. Psychiatry Res 110 IssueID2 103–115 Occurrence Handle10.1016/S0165-1781(02)00098-7 Occurrence Handle12057823

    Article  PubMed  Google Scholar 

  • Pfohl B, Blum N, Zimmerman M, Stangl D (1989) Structured interview for personality disorders, rev version. University of Iowa, Iowa City, IA

  • K Poikolainen (2002) ArticleTitleAntecedents of substance use in adolescence. Curr Opin Psychiatry 3 241–245 Occurrence Handle10.1097/00001504-200205000-00003

    Article  Google Scholar 

  • JF Quist CL Barr R Schachar W Roberts M Malone R Tannock VS Basile J Beitchman JL Kennedy (2003) ArticleTitleThe serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. Mol Psychiatry 8 IssueID1 98–102 Occurrence Handle10.1038/sj.mp.4001244 Occurrence Handle12556913

    Article  PubMed  Google Scholar 

  • NA Rector K Hood MA Richter RM Bagby (2002) ArticleTitleObsessive-compulsive disorder and the five-factor model of personality: distinction and overlap with major depressive disorder. Behav Res Ther 40 IssueID10 1205–1219 Occurrence Handle10.1016/S0005-7967(02)00024-4 Occurrence Handle12375729

    Article  PubMed  Google Scholar 

  • T Sander H Harms P Dufeu S Kuhn M Hoehe KP Lesch H Rommelspacher LG Schmidt (1998) ArticleTitleSerotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biol Psychiatry 43 IssueID12 908–912 Occurrence Handle10.1016/S0006-3223(97)00356-9 Occurrence Handle9627746

    Article  PubMed  Google Scholar 

  • J Schulenberg JG Bachman PM O’Malley LD Johnston (1994) ArticleTitleHigh school educational success and subsequent substance use: a panel analysis following adolescents into young adulthood. J Health Soc Behav 35 IssueID1 45–62 Occurrence Handle8014429

    PubMed  Google Scholar 

  • Spitzer RL, Williams JBW, Gibbon M, First MB (1990) Structured Clinical Interview according to DSM-III-R. First published by American Psychiatric Press, Washington DC and London, England

  • SF Stoltenberg GR Twitchell GL Hanna EH Cook HE Fitzgerald RA Zucker KY Little (2002) ArticleTitleSerotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism. Am J Med Genet 114 IssueID2 230–234 Occurrence Handle10.1002/ajmg.10187 Occurrence Handle11857587

    Article  PubMed  Google Scholar 

  • HF Sun YT Chang CS Fann CJ Chang YH Chen YP Hsu WY Yu AT Cheng (2002) ArticleTitleAssociation study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han. Biol Psychiatry 51 IssueID11 896–901 Occurrence Handle10.1016/S0006-3223(01)01366-X Occurrence Handle12022963

    Article  PubMed  Google Scholar 

  • J Tiihonen JT Kuikka KA Bergstrom J Karhu H Viinamaki J Lehtonen T Hallikainen J Yang P Hakola (1997) ArticleTitleSingle-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour. Eur J Nucl Med 24 IssueID10 1253–1260 Occurrence Handle10.1007/s002590050149 Occurrence Handle9323266

    Article  PubMed  Google Scholar 

  • T Turker R Sodmann U Goebel S Jatzke M Knapp KP Lesch R Schuster H Schutz G Weiler G Stober (1998) ArticleTitleHigh ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene. Neurosci Lett 248 147–150 Occurrence Handle10.1016/S0304-3940(98)00347-4 Occurrence Handle9654330

    Article  PubMed  Google Scholar 

  • GR Twitchell GL Hanna EH Cook SF Stoltenberg HE Fitzgerald And RA Zucker (2001) ArticleTitleSerotonin transporter promoter polymorphism genotype is associated with behavioral disinhibition and negative affect in children of alcoholics. Alcohol Clin Exp Res 25 IssueID7 953–959 Occurrence Handle10.1097/00000374-200107000-00002 Occurrence Handle11505018

    Article  PubMed  Google Scholar 

  • M Virkkunen M Linnoila (1990) ArticleTitleSerotonin in early onset, male alcoholics with violent behaviour. Ann Med 22 IssueID5 327–331 Occurrence Handle2291840

    PubMed  Google Scholar 

  • JS Waye L Presley B Budowle GG Shuttle RM Fourney (1989) ArticleTitleA simple method for quantifying human genomic DNA in forensic specimen extracts. Biotechniques 7 45–49

    Google Scholar 

  • TA Wills K DuHamel D Vaccaro (1995) ArticleTitleActivity and mood temperament as predictors of adolescent substance use: test of a self-regulation mediational model. J Pers Soc Psychol 68 IssueID5 901–916 Occurrence Handle10.1037/0022-3514.68.5.901 Occurrence Handle7776186

    Article  PubMed  Google Scholar 

  • TA Wills JM Sandy A Yaeger O Shinar (2001) ArticleTitleFamily risk factors and adolescent substance use: moderation effects for temperament dimensions. Dev Psychol 37 IssueID3 283–297 Occurrence Handle10.1037//0012-1649.37.3.283 Occurrence Handle11370906

    Article  PubMed  Google Scholar 

  • SE Young A Smolen RP Corley KS Krauter JC DeFries TJ Crowley JK Hewitt (2002) ArticleTitleDopamine transporter polymorphism associated with externalizing behavior problems in children. Am J Med Genet 114 IssueID2 144–149 Occurrence Handle10.1002/ajmg.10155 Occurrence Handle11857574

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Centro Studi Farmaco-tossicodipendenze, Ser.T., AUSL, Italy

    G. Gerra, L. Castaldini, A. Zaimovic, G. Moi, M. Bussandri, B. Branchi & F. Brambilla

  2. Reparto Investigazioni Scientifiche (RIS), Carabinieri di Parma, Università degli Studi di Parma, Parma, Italy

    L. Garofano

  3. Facoltà di Psicologia, Università degli Studi di Parma, Parma, Italy

    F. Rovetto

  4. Dipartimento di Genetica Antropologia Evoluzione, Università degli Studi di Parma, Parma, Italy

    G. Friso & C. Donnini

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Gerra, G., Garofano, L., Castaldini, L. et al. Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents. J Neural Transm 112, 1397–1410 (2005). https://doi.org/10.1007/s00702-004-0268-y

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