Multiple Intracerebral Haemangioblastomas in Identical Twins with von Hippel-Lindau Disease – a Clinical and Molecular Study

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, BRCA1, BRCA2, DCC, and MCC). Furthermore, no mutations were found in the constitutional DNA of either twin sister or in the DNA of all five tumour lesions. Based on our observations, we conclude that in certain VHL families, presymptomatic molecular diagnosis of the disease is not feasible and requires close clinical surveillance of all individuals at risk.