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Effect of amantadine in minimally conscious state of non-traumatic etiology

  • Letter to the editor - Brain Injury
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Fig. 1

References

  1. Akins PT, Guppy KH (2008) Sinking skin flaps, paradoxical herniation, and external brain tamponade: a review of decompressive craniectomy management. Neurocrit Care 9(2):269–276

    Article  PubMed  Google Scholar 

  2. Clauss RP (2010) Neurotransmitters in coma, vegetative and minimally conscious states, pharmacological interventions. Med Hypotheses 75(3):287–290

    Article  CAS  PubMed  Google Scholar 

  3. DeMarchi R, Bansal V, Hung A, Wroblewski K, Dua H, Sockalingam S, Bhalerao S (2005) Review of awakening agents. Can J Neurol Sci 32(1):4–17

    PubMed  Google Scholar 

  4. Georgiopoulos M, Katsakiori P, Kefalopoulou Z, Ellul J, Chroni E, Constantoyannis C (2010) Vegetative state and minimally conscious state: a review of the therapeutic interventions. Stereotact Funct Neurosurg 88(4):199–207

    Article  PubMed  Google Scholar 

  5. Giacino JT, Ashwal S, Childs N, Cranford R, Jennett B, Katz DI, Kelly JP, Rosenberg JH, Whyte J, Zafonte RD, Zasler ND (2002) The minimally conscious state: definition and diagnostic criteria. Neurology 58(3):349–353

    Article  PubMed  Google Scholar 

  6. Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M (2012) Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med 366(9):819–826

    Article  CAS  PubMed  Google Scholar 

  7. Joseph V, Reilly P (2009) Syndrome of the trephined. J Neurosurg 111(4):650–652

    Article  PubMed  Google Scholar 

  8. Lazaridis C, Czosnyka M (2012) Cerebral blood flow, brain tissue oxygen, and metabolic effects of decompressive craniectomy. Neurocrit Care 16(3):478–484

    Article  CAS  PubMed  Google Scholar 

  9. McMahon MA, Vargus-Adams JN, Michaud LJ, Bean J (2009) Effects of amantadine in children with impaired consciousness caused by acquired brain injury: a pilot study. Am J Phys Med Rehabil 88(7):525–532

    Article  PubMed  Google Scholar 

  10. Oyelese AA, Steinberg GK, Huhn SL, Wijman CA (2005) Paradoxical cerebral herniation secondary to lumbar puncture after decompressive craniectomy for a large space-occupying hemispheric stroke: case report. Neurosurgery 57(3):E594

    Article  PubMed  Google Scholar 

  11. Rahme R, Bojanowski MW (2010) Overt cerebrospinal fluid drainage is not a sine qua non for paradoxical herniation after decompressive craniectomy: case report. Neurosurgery 67(1):214–215, discussion 215

    Article  PubMed  Google Scholar 

  12. Reynolds JC, Rittenberger JC, Callaway CW (2013) Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest. Resuscitation 84(6):818–824

    Article  CAS  PubMed  Google Scholar 

  13. Schnakers C, Hustinx R, Vandewalle G, Majerus S, Moonen G, Boly M, Vanhaudenhuyse A, Laureys S (2008) Measuring the effect of amantadine in chronic anoxic minimally conscious state. J Neurol Neurosurg Psychiatry 79(2):225–227

    Article  CAS  PubMed  Google Scholar 

  14. Schwartz M, Patel M, Kazzi Z, Morgan B (2008) Cardiotoxicity after massive amantadine overdose. J Med Toxicol 4(3):173–179

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

The authors would like to thank Mrs Ingrid Carranza for the preparation of the illustrations.

Conflicts of interest

None.

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Authors and Affiliations

  1. Department of Neurosurgery, Hospital Clínico San Carlos, Prof. Martín Lagos s/n, 28040, Madrid, Spain

    Josue M. Avecillas-Chasín & Juan A. Barcia

Authors
  1. Josue M. Avecillas-Chasín
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  2. Juan A. Barcia
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Corresponding author

Correspondence to Josue M. Avecillas-Chasín.

Additional information

Comment

The authors provide a letter to the editor describing one patient in a minimally conscious state (MCS) of non-traumatic etiology sufficiently treated with amantadine. As the authors point out, amantadine has recently been described in patients with post-traumatic disorders of consciousness (DOC) and not in the treatment of non-traumatic DOC. Even though one may argue that a large post-interventional intracerebral hematoma is also some kind of trauma, in my opinion, publication of the present case is warranted to induce controlled clinical studies.

Marcus Reinges

Giessen, Germany

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Avecillas-Chasín, J.M., Barcia, J.A. Effect of amantadine in minimally conscious state of non-traumatic etiology. Acta Neurochir 156, 1375–1377 (2014). https://doi.org/10.1007/s00701-014-2077-x

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  • DOI: https://doi.org/10.1007/s00701-014-2077-x

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