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Paper-based substrates for surface-enhanced Raman spectroscopy sensing

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Abstract

Surface-enhanced Raman scattering (SERS) has been recognized as one of the most sensitive analytical methods by adsorbing the target of interest onto a plasmonic surface. Growing attention has been directed towards the fabrication of various substrates to broaden SERS applications. Among these, flexible SERS substrates, particularly paper-based ones, have gained popularity due to their easy-to-use features by full contact with the sample surface. Herein, we reviewed the latest advancements in flexible SERS substrates, with a focus on paper-based substrates. Firstly, it begins by introducing various methods for preparing paper-based substrates and highlights their advantages through several illustrative examples. Subsequently, we demonstrated the booming applications of these paper-based SERS substrates in abiotic and biological matrix detection, with particular emphasis on their potential application in clinical diagnosis. Finally, the prospects and challenges of paper-based SERS substrates in broader applications are discussed.

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Funding

This research was supported by the National Natural Science Foundation of China (21904068), the Natural Science Foundation of Jiangsu Province (BK20201351), Jiangsu Specially Appointed Professor program, Introduction of talent research start fund of Nanjing Medical University (NMUR2019007). Shanghai Key Lab of Forensic Science, Ministry of Justice, China (Academy of Forensic Science Open subject) (KF202006). Chunhui Project Foundation of the Education Department of China (HZKY20220178).

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  1. Department of Forensic Medicine, Nanjing Medical University, Nanjing, 211166, People’s Republic of China

    Yue Cao & Yang Sun

  2. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China

    Ru-Jia Yu & Yi-Tao Long

  3. Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, 210023, China

    Ru-Jia Yu

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Cao, Y., Sun, Y., Yu, RJ. et al. Paper-based substrates for surface-enhanced Raman spectroscopy sensing. Microchim Acta 191, 8 (2024). https://doi.org/10.1007/s00604-023-06086-2

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