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Nanostructured nickel oxide electrodes for non-enzymatic electrochemical glucose sensing

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Abstract

Nanostructured nickel (Ni) and nickel oxide (NiO) electrodes were fabricated on Ni foils using the glancing angle deposition (GLAD) technique. Cyclic voltammetry and amperometry showed the electrodes enable non-enzymatic electrochemical determination of glucose in strongly alkaline media. Under optimized conditions of NaOH concentration and working potential (~ 0.50 V vs. Ag/AgCl), the GLAD electrodes performed far better than bare Ni foil electrodes, with the GLAD NiO electrode showing an outstanding sensitivity (4400 μA mM−1 cm−2), superior detection limit (7 nM), and wide dynamic range (0.5 μM–9 mM), with desirable selectivity and reproducibility. Based on their performance at a low concentration, the GLAD NiO electrodes were also used to quantify glucose in artificial urine and sweat samples which have significantly lower glucose levels than blood. The GLAD NiO electrodes showed negligible response to the common interferents in glucose measurement (uric acid, dopamine, serotonin, and ascorbic acid), and they were not poisoned by high amounts of sodium chloride.

The figures depict (A) SEM image of vertical post-GLAD NiO electrodes used for non-enzymatic electrochemical glucose monitoring, and (B) calibration plots of the three different electrodes.

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Acknowledgements

The authors acknowledge Prof. Jeremy Sit for access to the GLAD evaporation equipment and Paul Concepcion for SEM imaging.

Funding

Natasha Singer and Aliesha Johnson received financial assistance from the NRC Student Employment Program.

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Authors and Affiliations

  1. National Research Council Canada - Nanotechnology Research Centre, 11421 - Saskatchewan Drive, Edmonton, AB, T6G 2M9, Canada

    Natasha Singer, Rajesh G. Pillai, Aliesha I. D. Johnson, Kenneth D. Harris & Abebaw B. Jemere

  2. Department of Mechanical Engineering, University of Alberta, Edmonton, AB, T6G 1H9, Canada

    Aliesha I. D. Johnson & Kenneth D. Harris

Authors
  1. Natasha Singer
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  2. Rajesh G. Pillai
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  3. Aliesha I. D. Johnson
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  5. Abebaw B. Jemere
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Correspondence to Abebaw B. Jemere.

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Singer, N., Pillai, R.G., Johnson, A.I.D. et al. Nanostructured nickel oxide electrodes for non-enzymatic electrochemical glucose sensing. Microchim Acta 187, 196 (2020). https://doi.org/10.1007/s00604-020-4171-5

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