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Self-assembled matrix fabricated by Fe-metal organic frameworks and carboxymethyl cellulose for the determination of small molecules by MALDI-TOF MS

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Abstract

A nanoprobe of laser desorption/ionization-time of flight mass spectrometry (LDI-TOF MS) for the determination of small molecules was developed that is based on the composition of Fe-metal organic frameworks (Fe-MOFs) and carboxymethyl cellulose-Na (CMC-Na). This material is a good adsorbent for small molecules via hydrogen bonding and π-interactions; we detected three molecules, dopamine, glyphosate, and pyrene. The detection limits for these compounds are 0.01 mg L−1, 1.50 μg L−1, and 0.01 μg L−1, respectively; the recoveries are 85–117%, 81–127%, and 89–115%, respectively. The relative standard deviations (~ 15%) and coefficients of determination of the calibration plot (~ 0.97) are satisfactory. The applicability of the chip for practical samples is demonstrated by quantifying pyrene in domestic water and polluted lake water; the recoveries are about 90~117% and 85~125% (n = 5), respectively; the RSDs are 9.4% and 13.5%, respectively.

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References

  1. Abdelhamid HN (2018) Nanoparticle assisted laser desorption/ionization mass spectro-metry for small molecule analytes. Microchim Acta 185:1–16

    Article  CAS  Google Scholar 

  2. Shi CY, Deng CH (2016) Recent advances in inorganic materials for LDI-MS analysis of small molecules. ACS Nano 141:2816–2826

    CAS  Google Scholar 

  3. Kim J (2015) Sample preparation for matrix-assisted laser desorption/ionization mass spectrometry. Mass Spectrom Lett 6:27–30

    Article  CAS  Google Scholar 

  4. Alexovič M, Dotsikas Y, Bober P, Sabo J (2018) Achievements in robotic automation of solvent extraction and related approaches for bioanalysis of pharmaceuticals. J Chromatogr B 1092:402–421

    Article  Google Scholar 

  5. Yin HQ, Yang JC, Yin XB (2017) Ratiometric fluorescence sensing and real-time detection of water in organic solvents with one-pot synthesis of Ru@MIL-101(Al)−NH2. Anal Chem 89:13434–13440

    Article  CAS  PubMed  Google Scholar 

  6. Hason S, Ostatna V, Fojta M (2020) Simultaneous voltammetric determination of free tryptophan, uric acid, xanthine and hypoxanthine in plasma and urine. Electrochim Acta 329:135132

    Article  CAS  Google Scholar 

  7. Alipanahpour DE, Ghaedi M, Asfaram A (2017) Optimization and modeling of pre-concentration and determination of dyes based on ultrasound assisted-dispersive liquid–liquid microextraction coupled with derivative spectrophotometry. Ultrason Sonochem 34:27–36

    Article  Google Scholar 

  8. Mehrabi F, Vafaei A, Ghaedi M (2017) Ultrasound assisted extraction of Maxilon Red GRL dye from water samples using cobalt ferrite nanoparticles loaded on activated carbon as sorbent: optimization and modeling. Ultrason Sonochem 38:672–680

    Article  CAS  PubMed  Google Scholar 

  9. Abdelhamid HN (2019) Nanoparticle-based surface assisted laser desorption ionization mass spectrometry: a review. Microchim Acta 186:682–716

    Article  Google Scholar 

  10. Abdelhamid HN, Wu HF (2019) A new binary matrix for specific detection of mercury(II) using matrix-assisted laser desorption ionization mass spectrometry. J Am Soc Mass Spectrom 30:2617–2622

    Article  CAS  PubMed  Google Scholar 

  11. Wen XJ, Dagan W, Wysocki VH (2007) Small-molecule analysis with silicon-nanoparticle-assisted laser desorption ionization mass spectrometry. Anal Chem 79:434–444

    Article  CAS  PubMed  Google Scholar 

  12. Gholipour Y, Giudicessi SL, Nonami H, Erra-Balsells R (2010) Diamond, titanium dioxide, titanium silicon oxide, and barium strontium titanium oxide nanoparticles as matrixes for direct matrix-assisted laser desorption/ionization mass spectrometry analysis of carbohydrates in plant tissues. Anal Chem 82:5518–5526

  13. Min QH, Zhang XX, Chen XQ, Li S, Zhu JJ (2014) N-doped graphene: an alternative carbon-based matrix for highly efficient determination of small molecules by negative ion MALDI-TOF MS. Anal Chem 86:9122–9130

  14. Wang XY, Dou SZ, Wang ZS, du J, Lu N (2020) Carbon nanoparticles derived from carbon soot as a matrix for SALDI-MS analysis. Microchim Acta 187:161

    Article  CAS  Google Scholar 

  15. Zhao XY, Cheng G, Yu H et al (2019) Combination strategy of reactive and catalytic matrices for qualitative and quantitative profiling of N-Glycans in MALDI-MS. Anal Chem 91:9251–9258

    Article  CAS  PubMed  Google Scholar 

  16. Ling L, Xiao CS, Yao M, et al (2019) 2-Phenyl-3-(p-aminophenyl) acrylonitrile: a reactive matrix for sensitive and selective analysis of glycans by MALDI-MS. Anal Chem 91:8801–8807

  17. Luis V, Abdelhamid HN (2019) Nanocellulose leaf-like zeolitic imidazolate framework (ZIF-L) foams for selective capture of carbon dioxide. Carbohydr Polym 213:338–345

    Article  Google Scholar 

  18. Chen LF, Ou JJ, Wang HW, Liu Z, Ye M, Zou H (2016) Tailor-made stable Zr(IV)-based metal-organic frameworks for laser desorption/ionization mass spectrometry analysis of small molecules and simultaneous enrichment of phosphopeptides. ACS Appl Mater Interfaces 8:20292–20300

  19. Kurt BZ, Uckaya F, Durmus Z (2016) Chitosan and carboxymethyl cellulose based magnetic nanocomposites for application of peroxidase purification. Int J Biol Macromol 96:149–160

    Article  Google Scholar 

  20. Li ZC, Liu XM, Jin W, Hu Q, Zhao Y (2019) Adsorption behavior of arsenicals on MIL-101(Fe): the role of arsenic chemical structures. J Colloid Interface Sci 554:692–704

    Article  CAS  PubMed  Google Scholar 

  21. Wang C, Ge XS, Jiang YJ (2019) Synergistic effect of graphene oxide/montmorillonite-sodium carboxymethycellulose ternary mimic-nacre nanocomposites prepared via a facile evaporation and hot pressing technique. Carbohydr Polym 222:115026

    Article  CAS  PubMed  Google Scholar 

  22. Zhang JP, Zhou HL, Zhou DD, Liao PQ, Chen XM (2018) Controlling flexibility of metal–organic frameworks. Natl Sci Rev 5:907–919

    Article  CAS  Google Scholar 

  23. Palit S, Singh K, Lou BS et al (2020) Ultrasensitive dopamine detection of indium-zinc oxide on PET flexible based extended-gate field-effect transistor. Sensors Actuators B Chem 310:127850

    Article  CAS  Google Scholar 

  24. Ling Y, Wang L, Zhang XY et al (2020) Ratiometric fluorescence detection of dopamine based on effect of ligand on the emission of Ag nanoclusters and aggregation-induced emission enhancement. Sensors Actuators B Chem 310:127858

    Article  CAS  Google Scholar 

  25. Chen S, Wang CH, Zhang M, Zhang W, Qi J, Sun X, Wang L, Li J (2020) N-doped Cu-MOFs for efficient electrochemical determination of dopamine and sulfanilamide. J Hazard Mater 390:122157

  26. Amirhassan A, Mehdi B, Fatemeh K et al (2020) Graphene oxide/polydimethylsiloxane-coated stainless steel mesh for use in solid-phase extraction cartridges and extraction of polycyclic aromatic hydrocarbons. Microchim Acta 187:213

    Article  Google Scholar 

  27. Alexander C, Veronica M, María José C, et al (2020) SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection. ACS Sens 5:693–702

  28. Ma YR, Zhang XL, Zeng T, Cao D, Zhou Z, Li WH, Niu H, Cai YQ (2013) Polydopamine-coated magnetic nanoparticles for enrichment and direct determination of small molecule pollutants coupled with MALDI TOF-MS. ACS Appl Mater Interfaces 5:1024–1030

  29. Gotti R, Fiori J, Bosi S, Dinelli G (2019) Field-amplified sample injection and sweeping micellar electrokinetic chromatography in analysis of glyphosate and aminomethylphosphonic acid in wheat. J Chromatogr A 1601:357–364

  30. Usui K, Minami E, Fujita YJ, Kubota E, Kobayashi H, Hanazawa T, Yoshizawa T, Kamijo Y, Funayama M (2019) Application of probe electrospray ionization-tandem mass spectrometry to ultra-rapid determination of glufosinate and glyphosate in human serum. J Pharm Biomed Anal 174:175–181

  31. Carrette L, Cardinali A, Marotta E, Zanin G et al (2019) A new rapid procedure for simultaneous determination of glyphosate and AMPA in water at sub μg/L level. J Chromatogr A 1600:65–72

    Article  Google Scholar 

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Funding

This work is funded by the National Natural Science Foundation of China (21874073).

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Authors and Affiliations

  1. Research Center for Analytical Science, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China

    Yingchen Yang & Yan Xia

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  1. Yingchen Yang
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  2. Yan Xia
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Correspondence to Yan Xia.

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Highlights

• Fe-MOFs and CMC-Na were combined through self-assembling and used as laser desorption/ionization mass spectrometry matrix.

• This combined material can overcome the poor water stability of MOFs by the incorporation with CMC-Na, which is highly stable in polar solvents.

• More importantly, the poor electron-conductive properties of MOFs can also be resolved by this method due to the higher conductivity of CMC-Na.

• The composite materials can sensitively detect small molecules with extremely low limit of determination, including dopamine, glyphosate, and pyrene via π-interaction and hydrogen bonding.

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Yang, Y., Xia, Y. Self-assembled matrix fabricated by Fe-metal organic frameworks and carboxymethyl cellulose for the determination of small molecules by MALDI-TOF MS. Microchim Acta 187, 445 (2020). https://doi.org/10.1007/s00604-020-04397-2

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