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Molecularly imprinted polydopamine modified with nickel nanoparticles wrapped with carbon: fabrication, characterization and electrochemical detection of uric acid

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Abstract

An electrochemical sensor is described for determination of uric acid (UA). Carbon-enwrapped nickel nanoparticles (Ni@BC) were coated with polydopamine (PDA) that was molecularly imprinted with UA. The biomass carbon (BC) was synthesized by one-step solid-state pyrolysis from leaves of Firmiana platanifolia. The imprinted polymer was obtained by electrodeposition of DA as the monomer. The amount of monomer, the scan cycles, pH value and adsorption time were optimized. Furthermore, the selectivity of the MIP for UA on a glassy carbon electrode (GCE) was evaluated by selectivity tests. The differential pulse voltammetric responses to UA with and without interferents were consistent. The modified GCE has a linear response in the 0.01–30 μM UA concentration range, and the limit of detection is 8 nM. The MIP electrode was applied to the analysis of UA in urine for which the initial concentrations were determined by the phosphotungstic acid kit. Recoveries ranged from 91.3 to 113.4%, with relative standard deviations between 1.3 and 9.7% (n = 3).

Schematic presentation of electrochemical detection of uric acid by molecularly imprinted polydopamine modified with nickel nanoparticles wrapped with carbon (Ni@BC-MIP).

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Acknowledgements

This work was supported by the following grant: The Two-Way Support Programs of Sichuan Agricultural University, P. R. China (03570113), the Education Department of Sichuan Province, P. R. China (16ZA0039).

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Authors and Affiliations

  1. College of Science, Sichuan Agricultural University, Xinkang Road, Yucheng District, Ya’an, 625014, People’s Republic of China

    Yanying Wang, Xin Liu, Zhiwei Lu, Ping Zou, Xianxiang Wang & Hanbing Rao

  2. College of Information Engineering, Sichuan Agricultural University, Xinkang Road, Yucheng District, Ya’an, 625014, People’s Republic of China

    Tao Liu

  3. Ministry of Agriculture and Rural Affairs Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry, Chengdu, 610065, People’s Republic of China

    Lijun Zhao

  4. Nanshan District Key Lab for Biopolymers and Safety Evaluation, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, People’s Republic of China

    Fang Ding

  5. Key Laboratory of Polar Materials and Devices, Ministry of Education, Department of Optoelectronics, East China Normal University, Shanghai, 200241, People’s Republic of China

    Qingbiao Zhao

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  1. Yanying Wang
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Wang, Y., Liu, X., Lu, Z. et al. Molecularly imprinted polydopamine modified with nickel nanoparticles wrapped with carbon: fabrication, characterization and electrochemical detection of uric acid. Microchim Acta 186, 414 (2019). https://doi.org/10.1007/s00604-019-3521-7

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