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Functionalization of a carbon nanofiber with a tetrasulfonatophenyl ruthenium(II)porphine complex for real-time amperometric sensing of chlorpromazine

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Abstract

A carbon nanofiber functionalized with ruthenium(II)-tetrasulfonato phenyl porphine (CNF/Ru-TSPP) is shown to be viable sensor for amperometric determination of the antipsychotic drug chlorpromazine (CPZ). The hollow platelet structured Ru-TSPP combines with the hollow cylindrical tube-like structure of the CNF via π stacking interaction. The morphological and electro conductive properties of the electrode were characterized by spectrophotometric techniques. The CNF/Ru-TSPP modified electrode displays a large surface-to-volume ratio, good electron transport and good electrocatalytic activity. The amperometric sensor, typically operated at a potential 0.63 V (vs. Ag/AgCl) exhibits a linear response in the 0.6 nM to 1.1 mM CPZ concentration range, has a 0.2 nM detection limit, and a remarkably good electrochemical sensitivity (2.405 μA μM−1 cm−2). The sensor is selective, repeatable and reproducible. It was successfully applied to the determination of CPZ in spiked serum samples.

Schematic presentation of carbon nanofiber/ tetrasulfonatophenyl Ruthenium(II)porphine (CNF/Ru-TSPP) nanocomposite synthesis and application for the electrochemical determination of chlorpromazine (CPZ).

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Acknowledgements

This project was supported by the Ministry of Science and Technology (MOST 107-2113-M- 027-005-MY3), Taiwan, ROC.

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Authors and Affiliations

  1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 106, Taiwan, Republic of China

    Rajalakshmi Sakthivel & Shen-Ming Chen

  2. Genomics Research Center, Academia Sinica, Taipei, Taiwan

    Subbiramaniyan Kubendhiran

  3. Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan

    Subbiramaniyan Kubendhiran

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  1. Rajalakshmi Sakthivel
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  2. Subbiramaniyan Kubendhiran
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  3. Shen-Ming Chen
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Correspondence to Shen-Ming Chen.

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Sakthivel, R., Kubendhiran, S. & Chen, SM. Functionalization of a carbon nanofiber with a tetrasulfonatophenyl ruthenium(II)porphine complex for real-time amperometric sensing of chlorpromazine. Microchim Acta 186, 285 (2019). https://doi.org/10.1007/s00604-019-3384-y

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