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A nanocomposite prepared from magnetite nanoparticles, polyaniline and carboxy-modified graphene oxide for non-enzymatic sensing of glucose

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Abstract

The authors report on the synthesis of carboxy functionalized graphene oxide (fGO) decorated with magnetite (Fe3O4) nanoparticles. The resulting nanomaterial was used to prepare a composite with polyaniline (PANI) which was characterized by UV-vis, Fourier transform-infrared and Raman spectroscopies. Its surface morphologies were characterized by atomic force and scanning electron microscopies. A screen-printed carbon electrode was then modified with the nanocomposite to obtain an enzyme-free glucose sensor. The large surface of fGO and Fe3O4 along with the enhanced charge transfer capability of PANI warrant a pronounced electrochemical response (typically measured at 0.18 V versus Ag/AgCl) which is suppressed in the presence of glucose. This reduction of current by glucose was used to design a sensitive method for quantification of glucose. The response of the modified SPCE is linear in the 0.05 μM – 5 mM glucose concentration range, and the lower detection limit is 0.01 μM.

Schematic illustration of in-situ anchoring of Iron oxide on functionalized graphene oxide and synthesis of its polymeric nanocomposite for non-enzymatic detection of Glucose. The nanocomposite modified screen printed interface enabled monitoring of glucose at lower potential with higher precision. GO (graphene oxide), fGO (functionalized graphene oxide), PANI (polyaniline).

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Acknowledgments

M. H. N thanks the Higher Education Commission of Pakistan for financial assistance under start-up research grant and national research program for universities (21-329/SRGP/R&D/HEC/2014 and 20-4993/R&D/HEC/14/614). R. B acknowledges the HEC supported studentship under NRPU.

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Authors and Affiliations

  1. Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad Lahore Campus, Lahore, 55150, Pakistan

    Razia Batool, Muhammad Asim Akhtar, Akhtar Hayat & Mian Hasnain Nawaz

  2. State Key Laboratory of Electroanalytical Chemistry, c/o Engineering Laboratory for Modern Analytical Techniques, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People’s Republic of China

    Dongxue Han, Li Niu & Mian Hasnain Nawaz

  3. Center for Advanced Analytical Science, c/o School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, 510006, People’s Republic of China

    Dongxue Han & Li Niu

  4. Department of Physics, COMSATS University Islamabad Lahore Campus, Lahore, 55150, Pakistan

    Muhammad Ashfaq Ahmad

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  1. Razia Batool
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  2. Muhammad Asim Akhtar
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  3. Akhtar Hayat
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  4. Dongxue Han
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  5. Li Niu
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Correspondence to Akhtar Hayat or Mian Hasnain Nawaz.

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Batool, R., Akhtar, M.A., Hayat, A. et al. A nanocomposite prepared from magnetite nanoparticles, polyaniline and carboxy-modified graphene oxide for non-enzymatic sensing of glucose. Microchim Acta 186, 267 (2019). https://doi.org/10.1007/s00604-019-3364-2

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