Skip to main content
Log in

Analysis of three genetic polymorphisms as risk factors for thrombosis

  • Letter To The Editor
  • Published:
International Journal of Clinical and Laboratory Research

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Frezzato M, Tosetto A, Vicentini S, Rodeghiero F. Prevalence of venous thrombosis (VT) in active population: an update of the VITA (Vicenza Thrombophilia and Arteriosclerosis) project. Thromb Haemost 1995; 73:951.

    Google Scholar 

  2. De Stefano V, Finazzi G, Mannucci PM. Inherited thrombophilia: pathogenesis, clinical syndromes and management. Blood 1996; 87:3531.

    PubMed  Google Scholar 

  3. Zoller B, Garcia de Frutos P, Hillarp A, Dahlback B. Thrombophilia as a multigenic disease. Haematologica 1999; 84:59

    PubMed  CAS  Google Scholar 

  4. Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A 1993; 90:1004.

    Article  PubMed  CAS  Google Scholar 

  5. Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Driven RJ, Ronde H de, Velden PA van der, Reistma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369:64.

    Article  PubMed  CAS  Google Scholar 

  6. Heijer M den, Koster T, Blom HJ, Bos GMJ, Briet E, Reitsma PH, Vandenbroucke JP, Rosendaal FR. Hyperhomocysteinemia as a risk factor for deep vein thrombosis. N Engl J Med 1996; 334:759

    Article  Google Scholar 

  7. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, Heijer M den, Kluijtmans LAJ, Heuvel LP van den, Rozen R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10:111.

    Article  PubMed  CAS  Google Scholar 

  8. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88:3698.

    PubMed  CAS  Google Scholar 

  9. D’Angelo A, Fermo I, D’Angelo SV. Thrombophilia, homocystinuria and mutation of the factor V gene. N Engl J Med 1996; 335:289.

    Article  PubMed  CAS  Google Scholar 

  10. Cattaneo M, Tsai MY, Bucciarelli P, Taili E, Zighetti ML, Bignell M, Mannucci PM. A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506). Arterioscler Thromb Vasc Biol 1997; 17:1662

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giordano, P., Coppola, B., Iolascon, A. et al. Analysis of three genetic polymorphisms as risk factors for thrombosis. Int J Clin Lab Res 29, 174–175 (1999). https://doi.org/10.1007/s005990050086

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s005990050086

Keywords

Navigation