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The prevalence and risk factors associated with preoperative deep venous thrombosis in lung cancer surgery

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Abstract

Purpose

Few studies have so far focused on the preoperative presence of venous thromboembolism (VTE) in lung cancer patients undergoing surgery. In this study, we investigated the prevalence and risk factors for preoperative deep venous thrombosis (DVT) in patients scheduled to undergo lung cancer surgery.

Methods

Between June 2013 and December 2018, 948 consecutive patients underwent lung cancer surgery in Kindai University Hospital. Four patients did not undergo screening for DVT; thus, 944 patients were enrolled in this study. Preoperatively, venous ultrasonography of the lower extremities was performed in patients deemed at risk for DVT, and the prevalence and risk factors for preoperative DVT were examined.

Results

Ninety-one patients (9.6%) were diagnosed with preoperative DVT, and postoperative symptomatic pulmonary thromboembolism occurred in one patient (0.11%). A multivariable logistic regression analysis demonstrated that female sex, age ≥ 72 years, history of VTE, a Wells score ≥ 2 points, chronic obstructive pulmonary disease (COPD), and lower hemoglobin levels were significantly associated with preoperative DVT.

Conclusion

Female sex, age ≥ 72 years, history of VTE, Wells score ≥ 2 points, COPD, and lower hemoglobin levels were identified to be independent risk factors for preoperative DVT. Monitoring for these risk factors and management considering them should help improve the outcomes after lung cancer surgery.

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Authors and Affiliations

  1. Division of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511, Japan

    Toshiki Takemoto, Junichi Soh, Shuta Ohara, Toshio Fujino, Takamasa Koga, Masaya Nishino, Akira Hamada, Masato Chiba, Masaki Shimoji, Kenichi Suda, Kenji Tomizawa & Tetsuya Mitsudomi

  2. Division of Thoracic Surgery, Department of Surgery, Izumi City General Hospital, 4-5-1 Wake, Izumi, 594-0073, Japan

    Masaki Shimoji & Kenji Tomizawa

Authors
  1. Toshiki Takemoto
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  2. Junichi Soh
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  3. Shuta Ohara
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  4. Toshio Fujino
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  5. Takamasa Koga
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  7. Akira Hamada
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  9. Masaki Shimoji
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  12. Tetsuya Mitsudomi
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Corresponding author

Correspondence to Toshiki Takemoto.

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The authors declare that they have no conflicts of interest.

Ethical approval

All procedures were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent or an approved substitute was obtained from all patients included in the study.

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Takemoto, T., Soh, J., Ohara, S. et al. The prevalence and risk factors associated with preoperative deep venous thrombosis in lung cancer surgery. Surg Today 51, 1480–1487 (2021). https://doi.org/10.1007/s00595-021-02243-3

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  • DOI: https://doi.org/10.1007/s00595-021-02243-3

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