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Outcomes of lung transplantation for idiopathic pleuroparenchymal fibroelastosis

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Abstract

Purpose

This study was performed to compare the outcome of lung transplantation (LT) for idiopathic pleuroparenchymal fibroelastosis (IPPFE) with that of LT for idiopathic pulmonary fibrosis (IPF).

Methods

We reviewed, retrospectively, all adult patients who underwent LT for IPPFE or IPF in Japan between 1998 and 2018.

Results

There were 100 patients eligible for this study (31 with IPPFE and 69 with IPF). Patients with IPPFE tended to have a significantly lower body mass index (BMI) than those with IPF (median, 16.7 vs. 22.6 kg/m2, respectively; P < 0.01). However, Kaplan–Meier survival curves showed no significant difference in overall survival between the groups. The BMI did not increase in patients with IPPFE, even 1 year after LT (pretransplant, 16.5 ± 3.2 kg/m2 vs. 1 year post-transplant, 15.6 ± 2.5 kg/m2; P = 0.08). The percent predicted forced vital capacity (%FVC) 1 year after LT was significantly lower in the IPPFE group than in the IPF group (48.4% ± 19.5% vs. 68.6% ± 15.5%, respectively; P < 0.01).

Conclusions

Despite extrapulmonary problems such as a flat chest, low BMI, and associated restrictive impairment persisting in patients with IPPFE, patient survival after LT for IPPFE or IPF was equivalent.

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Abbreviations

%DLco:

Percent predicted diffusing capacity of carbon monoxide

%FEV1 :

Percent predicted forced expiratory volume in 1 s

%FVC:

Percent predicted forced vital capacity

APDT:

Anteroposterior diameter of the thoracic cage

BMI:

Body mass index

FEV1 :

Forced expiratory volume in 1 s

FVC:

Forced vital capacity

ICU:

Intensive care unit

IIPs:

Idiopathic interstitial pneumonias

IPF:

Idiopathic pulmonary fibrosis

IPPFE:

Idiopathic pleuroparenchymal fibroelastosis

LT:

Lung transplantation

TDT:

Transverse diameter of the thoracic cage

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Acknowledgements

We thank the Japanese Society of Lung and Heart-Lung Transplantation for helping us to collect the patients’ data.

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Authors and Affiliations

  1. Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Haruhiko Shiiya, Jun Nakajima & Masaaki Sato

  2. Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate School of Medicine, Hokkaido, Japan

    Haruhiko Shiiya

  3. Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Hiroshi Date & Toyofumi Fengshi Chen-Yoshikawa

  4. Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Toyofumi Fengshi Chen-Yoshikawa

  5. Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Kiminobu Tanizawa

  6. Department of Advanced Medicine for Respiratory Failure, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Tomohiro Handa

  7. Department of Organ Transplant Center/General Thoracic Surgery, Okayama University Hospital, Okayama, Japan

    Takahiro Oto, Shinji Otani & Toshio Shiotani

  8. Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan

    Yoshinori Okada & Yasushi Matsuda

  9. Department of General Thoracic, Breast and Pediatric Surgery, Fukuoka University School of Medicine, Fukuoka, Japan

    Takeshi Shiraishi & Toshihiko Moroga

  10. Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

    Masato Minami & Soichiro Funaki

  11. Department of General Thoracic Surgery, Dokkyo Medical University, Tochigi, Japan

    Masayuki Chida

  12. Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan

    Ichiro Yoshino

  13. Department of Surgical Oncology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan

    Go Hatachi

  14. Biostatistics Section, Department of Data Science, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan

    Yukari Uemura

Authors
  1. Haruhiko Shiiya
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  2. Jun Nakajima
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  3. Hiroshi Date
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  4. Toyofumi Fengshi Chen-Yoshikawa
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  5. Kiminobu Tanizawa
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  6. Tomohiro Handa
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  8. Shinji Otani
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  10. Yoshinori Okada
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  11. Yasushi Matsuda
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  14. Masato Minami
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  15. Soichiro Funaki
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  16. Masayuki Chida
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  17. Ichiro Yoshino
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  18. Go Hatachi
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  19. Yukari Uemura
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  20. Masaaki Sato
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Corresponding author

Correspondence to Masaaki Sato.

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Shiiya, H., Nakajima, J., Date, H. et al. Outcomes of lung transplantation for idiopathic pleuroparenchymal fibroelastosis. Surg Today 51, 1276–1284 (2021). https://doi.org/10.1007/s00595-021-02232-6

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  • DOI: https://doi.org/10.1007/s00595-021-02232-6

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