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Pulmonary Inflammatory Myofibroblastic Tumor Resected by Video-Assisted Thoracoscopic Surgery: Report of a Case

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Abstract

Pulmonary inflammatory myofibroblastic tumor (IMT) is rare. A 38-year-old woman visited our hospital 2 days after experiencing transient anterior chest pain. Chest radiography showed a nodule suggestive of adenocarcinoma in the middle lobe; however, transbronchial lung biopsy and computed tomography (CT)-guided percutaneous needle cytology showed signs of inflammation. To obtain a definitive diagnosis we performed a wedge resection using video-assisted thoracoscopic surgery and removed the nodule completely. The pathologic diagnosis made during surgery was IMT. The longest dimension of the nodule was 28 mm. Immunohistochemical examination showed proliferating spindle cells, which were positive for vimentin and smooth muscle actin, but negative for desmin, CD34, cytokeratin, epithelial membrane antigen, S100 protein, and neuron specific enolase. These findings were consistent with the staining pattern of IMT previously reported. Careful follow-up is necessary to detect any sign of local recurrence and distant metastases.

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References

  1. T Horan (2000) ArticleTitleInflammatory pseudotumors of the lung Ann Thorac Surg 69 1295 Occurrence Handle10800851 Occurrence Handle10.1016/S0003-4975(00)01115-2 Occurrence Handle1:STN:280:DC%2BD3c3lvVOruw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  2. J Guthrie R Arthur (1994) ArticleTitleCase report: juvenile xanthogranuloma with pulmonary, subcutaneous and hepatic involvement Clin Radiol 49 498–500 Occurrence Handle8088048 Occurrence Handle10.1016/S0009-9260(05)81751-9 Occurrence Handle1:STN:280:DyaK2cznsVSmtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  3. G Kafeel P Telesinghe (1997) ArticleTitleInflammatory pseudotumour of the liver J Clin Pathol 50 352–3 Occurrence Handle9215157 Occurrence Handle1:STN:280:DyaK2szlsl2ktA%3D%3D

    PubMed  CAS  Google Scholar 

  4. A Sarker C An M Davis D Praprotnik L McCarthy A Orazi (2003) ArticleTitleInflammatory pseudotumor of the spleen in a 6-year-old child: a clinicopathologic study Arch Pathol Lab Med 127 127–30

    Google Scholar 

  5. H Babar-Craig H Gill R Almeyda W Wong R Farrell (2005) ArticleTitleInflammatory pseudotumour of the neck with multifocal sites on positron emission tomography scan imaging J Laryngol Otol 119 219–21 Occurrence Handle15845197 Occurrence Handle10.1258/0022215053561620

    Article  PubMed  Google Scholar 

  6. R Chetty D Govender (1997) ArticleTitleInflammatory pseudotumor of the breast Pathology 29 270–1 Occurrence Handle9271014 Occurrence Handle10.1080/00313029700169055 Occurrence Handle1:STN:280:DyaK2svhslSltw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  7. G Melloni A Carretta P Ciriaco G Arrigoni S Fieschi N Rizzo et al. (2005) ArticleTitleInflammatory pseudotumor of the lung in adults Ann Thorac Surg 79 426–32 Occurrence Handle15680808 Occurrence Handle10.1016/j.athoracsur.2004.07.077

    Article  PubMed  Google Scholar 

  8. G Hosler D Steinberg S Sheth U Hamper Y Erozan S Ali (2004) ArticleTitleInflammatory pseudotumor: a diagnostic dilemma in cytopathology Diagn Cytopathol 31 267–70 Occurrence Handle15452903 Occurrence Handle10.1002/dc.20113

    Article  PubMed  Google Scholar 

  9. Yousem SA, Tazelaar HD, Manabe T, Dehner LP. Inflammatory myofibroblastic tumour. In: Travis WD, Brambilla E, Muller-Hermelink KH, Harris CC editors. WHO classification of tumors, pathology and genetics, tumors of the lung, pleura, thymus and heart. IARC Press; 2004. p. 105–6

  10. R Cerfolio M Allen A Nascimento C Deschamps V Trastek D Miller et al. (1999) ArticleTitleInflammatory pseudotumors of the lung Ann Thorac Surg 67 933–6 Occurrence Handle10320231 Occurrence Handle10.1016/S0003-4975(99)00155-1 Occurrence Handle1:STN:280:DyaK1M3ltF2kuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  11. B Kazmierczak CP Dal R Sciot dBH Van J Bullerdiek (1999) ArticleTitleInflammatory myofibroblastic tumor with HMGIC rearrangement Cancer Genet Cytogenet 112 156–60 Occurrence Handle10686944 Occurrence Handle10.1016/S0165-4608(98)00268-4 Occurrence Handle1:STN:280:DC%2BD3c7ltFGlsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  12. C Coffin A Patel S Perkins K Elenitoba-Johnson E Perlman C Griffin (2001) ArticleTitleALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor Mod Pathol 14 569–76 Occurrence Handle11406658 Occurrence Handle10.1038/modpathol.3880352 Occurrence Handle1:STN:280:DC%2BD3Mzktlensw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  13. J Cook L Dehner M Collins Z Ma S Morris C Coffin et al. (2001) ArticleTitleAnaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study Am J Surg Pathol 25 1364–71 Occurrence Handle11684952 Occurrence Handle10.1097/00000478-200111000-00003 Occurrence Handle1:STN:280:DC%2BD3MnkvVehtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  14. S Yousem H Shaw K Cieply (2001) ArticleTitleInvolvement of 2p23 in pulmonary inflammatory pseudotumors Hum Pathol 32 428–33 Occurrence Handle11331960 Occurrence Handle10.1053/hupa.2001.23523 Occurrence Handle1:STN:280:DC%2BD3Mzis1SnsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  15. L Su A Atayde-Perez S Sheldon J Fletcher S Weiss (1998) ArticleTitleInflammatory myofibroblastic tumor: cytogenetic evidence supporting clonal origin Mod Pathol 11 364–8 Occurrence Handle9578087 Occurrence Handle1:STN:280:DyaK1c3jslWqug%3D%3D

    PubMed  CAS  Google Scholar 

  16. R Biselli C Ferlini A Fattorossi R Boldrini C Bosman (1996) ArticleTitleInflammatory myofibroblastic tumor (inflammatory pseudotumor): DNA flow cytometric analysis of nine pediatric cases Cancer 77 778–84 Occurrence Handle8616772 Occurrence Handle10.1002/(SICI)1097-0142(19960215)77:4<778::AID-CNCR25>3.0.CO;2-X Occurrence Handle1:STN:280:DyaK287os1yltg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  17. D Arber O Kamel M van de Rijn R Davis L Medeiros E Jaffe et al. (1995) ArticleTitleFrequent presence of the Epstein-Barr virus in inflammatory pseudotumor Hum Pathol 26 1093–8 Occurrence Handle7557942 Occurrence Handle10.1016/0046-8177(95)90271-6 Occurrence Handle1:STN:280:DyaK28%2Fhtl2huw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  18. J Lewis R Gaffney M Casey M Farrell W Morice W Macon (2003) ArticleTitleInflammatory pseudotumor of the spleen associated with a clonal Epstein-Barr virus genome. Case report and review of the literature Am J Clin Pathol 120 56–61 Occurrence Handle12866373 Occurrence Handle10.1309/BUWN-MG5R-V4D0-9YYH

    Article  PubMed  Google Scholar 

  19. J Gomez-Roman G Ocejo-Vinyals P Sanchez-Velasco E Nieto F Leyva-Cobian J Val-Bernal (2000) ArticleTitlePresence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor) Lab Invest 80 1121–6 Occurrence Handle10908158 Occurrence Handle1:CAS:528:DC%2BD3cXlsF2iurY%3D

    PubMed  CAS  Google Scholar 

  20. Y Ding R Saylors H Brown D Parham J Gomez-Roman P Sanchez-Velasco et al. (2002) ArticleTitlePulmonary inflammatory pseudotumor with HHV-8 Am J Surg Pathol 26 1089–91 Occurrence Handle12170101 Occurrence Handle10.1097/00000478-200208000-00021

    Article  PubMed  Google Scholar 

  21. S Kato K Kondo T Teramoto T Harada H Ikeda K Hara et al. (2002) ArticleTitleA case report of inflammatory pseudotumor of the lung: rapid recurrence appearing as multiple lung nodules Ann Thorac Cardiovasc Surg 8 224–7 Occurrence Handle12472387

    PubMed  Google Scholar 

  22. S Topcu I Tastepe A Alper A Ozdulger M Albayrak D Bozkurt et al. (2000) ArticleTitleInflammatory pseudotumors of the lung: a clinical study of eleven patients J Thorac Cardiovasc Surg 119 180–2 Occurrence Handle10612784 Occurrence Handle10.1016/S0022-5223(00)70240-6 Occurrence Handle1:STN:280:DC%2BD3c%2FotV2nsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  23. M Omasa T Kobayashi Y Takahashi J Tamada (2002) ArticleTitleSurgically treated pulmonary inflammatory pseudotumor Jpn J Thorac Cardiovasc Surg 50 305–8 Occurrence Handle12166272 Occurrence Handle10.1007/BF03032301

    Article  PubMed  Google Scholar 

  24. H Sakurai T Hasegawa S Watanabe K Suzuki H Asamura R Tsuchiya (2004) ArticleTitleInflammatory myofibroblastic tumor of the lung Eur J Cardiothorac Surg 25 155–9 Occurrence Handle14747105 Occurrence Handle10.1016/S1010-7940(03)00678-X

    Article  PubMed  Google Scholar 

  25. T Kim J Han G Kim K Lee H Kim J Kim (2005) ArticleTitlePulmonary inflammatory pseudotumor (inflammatory myofibroblastic tumor): CT features with pathologic correlation J Comput Assist Tomogr 29 633–9 Occurrence Handle16163033 Occurrence Handle10.1097/01.rct.0000168363.60191.f8

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Departments of Chest Surgery, Atami Hospital, International University of Health and Welfare, 13-1 Higashikaigan-cho, Atami, Shizuoka, 413-0012, Japan

    Haruhiko Nakamura, Norihito Kawasaki & Masahiko Taguchi

  2. Departments of Pathology, Atami Hospital, International University of Health and Welfare, 13-1 Higashikaigan-cho, Atami, Shizuoka, 413-0012, Japan

    Hajime Kitamura

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  1. Haruhiko Nakamura
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  2. Norihito Kawasaki
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  3. Masahiko Taguchi
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  4. Hajime Kitamura
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Nakamura, H., Kawasaki, N., Taguchi, M. et al. Pulmonary Inflammatory Myofibroblastic Tumor Resected by Video-Assisted Thoracoscopic Surgery: Report of a Case. Surg Today 37, 137–140 (2007). https://doi.org/10.1007/s00595-006-3344-0

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  • DOI: https://doi.org/10.1007/s00595-006-3344-0

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