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Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents

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Abstract

Type 2 diabetes risk and its relationship to free fatty acid (FFA) exposure and visceral fat by prediabetes status in minority adolescents have yet to be explored. Therefore, the objective of this study was to examine the association of circulating FFA under varying conditions with prediabetes in Latino adolescents and to determine the relative relationships of FFA and visceral adiposity to insulin sensitivity, secretion, and β-cell function. Overweight or obese, but otherwise healthy Latino adolescent males and females (n = 164, 14.2 ± 2.5 years), were recruited for assessment of prediabetes, abdominal fat, and FFA levels taken at a fasting state (FFAF), during an OGTT (FFAOGTT), and overnight (FFANOCTURNAL). Prediabetic adolescents had a higher FFAF than those with normal glucose tolerance when controlling for age, sex, pubertal status, total percent body fat, and visceral fat. FFAOGTT and FFANOCTURNAL did not differ between participants with prediabetes and those with normal glucose tolerance after adjusting for covariates. Visceral fat was independently related to insulin sensitivity and secretion in pubertal adolescents; however, in post-pubertal adolescents, FFAF and visceral fat were both independent and negatively related to β-cell function. These results support a plausible progression of the lipotoxicity theory of diabetes development during the pubertal transition.

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Acknowledgments

This study is supported by NCMHD Grant P60MD002254 (M.I.G and M.J.W.) and NIDDK Grant R01DK059211 (M.I.G.). C.M.T-C. is supported by an American Diabetes Association Postdoctoral Fellowship (7-10-MI-04). We would like to thank the staff of the University of Southern California/LA County GCRC and the dedicated DREAM and SOLAR-2 staff, Quintilia Ávila, MPA, Michelle Muñevar, MPH, Christina Ayala, MPH, and Laura Salguero, MS, and the rest of the staff over the past 5 years. Our gratitude is especially extended to the participants and their families for their participation.

Conflict of interest

Claudia Toledo-Corral, Tanya Alderete, Joyce Richey, Paola Sequeira, Michael Goran, and Marc Weigensberg have nothing to disclose.

Human and animal rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA

    Claudia M. Toledo-Corral, Tanya L. Alderete & Michael I. Goran

  2. Department of Public Health, California State University, Los Angeles, Los Angeles, CA, 90032, USA

    Claudia M. Toledo-Corral

  3. Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA, 90033, USA

    Joyce Richey & Michael I. Goran

  4. Department of Pediatrics, University of Southern California, 2250 Alcazar Street, CSC 200, Los Angeles, CA, 90033, USA

    Paola Sequeira & Marc J. Weigensberg

Authors
  1. Claudia M. Toledo-Corral
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  2. Tanya L. Alderete
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  3. Joyce Richey
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  4. Paola Sequeira
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  5. Michael I. Goran
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  6. Marc J. Weigensberg
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Corresponding author

Correspondence to Marc J. Weigensberg.

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Toledo-Corral, C.M., Alderete, T.L., Richey, J. et al. Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents. Acta Diabetol 52, 277–284 (2015). https://doi.org/10.1007/s00592-014-0634-7

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  • DOI: https://doi.org/10.1007/s00592-014-0634-7

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