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Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk

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Abstract

Insulin-like growth factor 2 mRNA-binding protein 2 (IFG2BP2) belongs to an mRNA-binding protein family involved in the development and stimulation of insulin action, which has attracted considerable attention as a candidate gene for type 2 diabetes (T2D) since it was first identified through genome-wide association approach. The relationship between IFG2BP2 and T2D has been reported in various ethnic groups; however, these studies have yielded contradictory results. To investigate this inconsistency, we performed a meta-analysis of 35 studies involving a total of 175,965 subjects for two wildly studied polymorphisms (rs4402960 and rs1470579) of the IFG2BP2 to evaluate the effect of IFG2BP2 on genetic susceptibility for T2D. An overall random-effects per-allele OR of 1.13 (95% CI: 1.12–1.15; P < 10−5) and 1.09 (95% CI: 1.07–1.12; P < 10−5) was found for the two variants, respectively. Significant results were also observed using dominant or recessive genetic model. No significant results between study heterogeneity were found in most of the comparison. In the subgroup analysis by ethnicity, sample size, diagnostic criterion and mean age and BMI of cases, significantly increased risks were found for these polymorphisms in almost all genetic models. This meta-analysis demonstrated that these two common polymorphisms is a risk factor for developing T2D, but these associations vary in different ethnic populations.

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Authors and Affiliations

  1. Department of Endocrinology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, 200433, People’s Republic of China

    Jie Wu

  2. Department of Pneumology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, 200433, People’s Republic of China

    Junjie Wu

  3. National Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, People’s Republic of China

    Junjie Wu, Shicheng Guo & Jie Liu

  4. Department of Health Statistics, Second Military Medical University, Shanghai, 200433, People’s Republic of China

    Yuhao Zhou

  5. Institute of Military Health Service Management, Second Military Medical University, Shanghai, 200433, People’s Republic of China

    Houdong Zou

  6. Department of Pneumology, Fengxian District Central Hospital of Shanghai, Nanfang Medical University, Shanghai, 201400, People’s Republic of China

    Liwen Lu

  7. Department of Respiratory, Second Hospital, Zhejiang University School of Medicine, Jiefang Road 88, Hangzhou, 310009, People’s Republic of China

    Hao Xu

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  1. Jie Wu
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  2. Junjie Wu
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  3. Yuhao Zhou
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  4. Houdong Zou
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  5. Shicheng Guo
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  6. Jie Liu
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  7. Liwen Lu
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  8. Hao Xu
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Correspondence to Liwen Lu or Hao Xu.

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Jie Wu and Junjie Wu contributed equally to this work.

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Wu, J., Wu, J., Zhou, Y. et al. Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk. Acta Diabetol 49 (Suppl 1), 87–97 (2012). https://doi.org/10.1007/s00592-011-0336-3

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