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Can platelet-rich plasma shorten the consolidation phase of distraction osteogenesis? An experimental study

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European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study was to evaluate the effects of platelet-rich plasma (PRP) on distraction osteogenesis.

Materials and methods

Tibias of 36 New Zealand white rabbits were distracted at a rate of 0.25 mm/8 h for 20 days with a circular external fixator. The animals were randomly divided into a control group that did not receive PRP therapy and an experimental group, with PRP injection into the distracted area. Radiographic examinations were performed at the 10th, 20th, 30th, 40th and 50th days after end of distraction. By the 50th day after distraction, all animals were sacrificed, the external fixator was removed and the tibia was dissected. After that, each group was subdivided into two subgroups: one for pathological study and another one for mechanical study.

Results

Radiologic scores were statistically similar at the 10th, 20th and 30th days. However, the experimental group demonstrated higher radiologic scores at the 40th and 50th days. Histopathologic examination revealed a statistically significant higher score in the experimental group. The PRP injected group showed an improvement of their mechanical properties.

Conclusion

The results of this study show that PRP has beneficial effects on new bone formation during distraction osteogenesis.

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Conflict of interest

The authors do not have any conflict of interest.

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Authors and Affiliations

  1. Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Ayman M. Ali, Barakat El-Alfy, Maha Amin & Mostafa Nematalla

  2. Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt

    El-Sayed A. El-Shafaey

Authors
  1. Ayman M. Ali
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  2. Barakat El-Alfy
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  3. Maha Amin
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  4. Mostafa Nematalla
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  5. El-Sayed A. El-Shafaey
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Correspondence to Ayman M. Ali.

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Ali, A.M., El-Alfy, B., Amin, M. et al. Can platelet-rich plasma shorten the consolidation phase of distraction osteogenesis? An experimental study. Eur J Orthop Surg Traumatol 25, 543–548 (2015). https://doi.org/10.1007/s00590-014-1542-9

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  • DOI: https://doi.org/10.1007/s00590-014-1542-9

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