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Cervical spine meniscoids: an update on their morphological characteristics and potential clinical significance

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Abstract

Purpose

Cervical spine meniscoids are intra-articular folds of synovial membrane that have been theorised to have potential clinical significance in neck pain. Recent anatomical and clinical research has re-visited the pathoanatomical capacity of these structures. The purpose of this review is to discuss cervical spine meniscoid morphology in light of recently published work, to provide an update on the plausible relevance of these structures to clinical practice.

Methods

Narrative review critically discussing basic science and clinical research regarding cervical spine meniscoids, with focus upon implications for clinical practice.

Results

Basic science research indicates that cervical spine meniscoids can be innervated and appear to vary in morphology in the presence of articular degeneration. In a clinical population, associations have been observed between cervical spine meniscoid morphology and presence of cervical spine symptoms.

Conclusions

Recent studies regarding cervical spine meniscoid morphology provide further evidence of pathoanatomical capacity of these structures. Further research is required, however, in clinical populations to empirically investigate specific theorised mechanisms of cervical spine meniscoid involvement in neck pain.

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References

  1. Webb AL, Collins P, Rassoulian H, Mitchell BS (2011) Synovial folds—a pain in the neck? Man Ther 16:118–124

    Article  PubMed  Google Scholar 

  2. Mercer S, Bogduk N (1993) Intra-articular inclusions of the cervical synovial joints. J Rheumatol 32(8):705–710

    Article  CAS  Google Scholar 

  3. Farrell SF, Osmotherly PG, Rivett DA, Cornwall J (2015) Can E12 sheet plastination be used to examine the presence and incidence of intra-articular spinal meniscoids? Anatomy 9(1):13–18. doi:10.2399/ana.14.046

    Article  Google Scholar 

  4. Friedrich KM, Reiter G, Pretterkliedber ML, Pinker K, Friedrich M, Trattnig S, Salomonowitz E (2008) Reference data for in vivo magnetic resonance imaging properties of meniscoids in the cervical zygapophyseal joints. Spine 33(21):E778–E783

    Article  PubMed  Google Scholar 

  5. Friedrich KM, Trattnig S, Millington SA, Friedrich M, Groschmidt K, Pretterkliedber ML (2007) High-field magnetic resonance imaging of meniscoids in the zygapophyseal joints of the human cervical spine. Spine (Phila Pa 1976) 32(2):244–248

    Article  Google Scholar 

  6. Farrell SF, Osmotherly PG, Cornwall J, Lau P, Rivett DA (2016) Morphology of cervical spine meniscoids in individuals with chronic whiplash associated disorder: a case-control study. J Orthop Sports Phys Ther 46(10):902–910. doi:10.2519/jospt.2016.6702

    Article  PubMed  Google Scholar 

  7. Dörr WM (1958) Uber die Anatomie der Wirbelgelenke. Archiv fur Orthopadische und Unfall-Chirurgie 50(3):222–234

    Article  PubMed  Google Scholar 

  8. De Marchi GF (1963) Le articolazioni intervertebrali: studio anatomo-istologico. La Clinica Ortopedica 15(1):26–33

    Google Scholar 

  9. Penning L, Toendury G (1963) Origin, structure and function of meniscoid structures in the cervical vertebral joints. Z Orthop Ihre Grenzgeb 98:1–14

    CAS  PubMed  Google Scholar 

  10. Schmincke A, Santo E (1932) Zur normalen und pathologischen anatomie der halswirbelsaule. Zentralbl Allg Pathol Anat 55:369–372

    Google Scholar 

  11. Tondury G (1940) Bietrag zur kenntniss der kleinen wirbelgelenke. Zeitschrift fur Anatomie und Entwicklungsgeschichte 110(4):568–575

    Article  Google Scholar 

  12. Zaccheo D, Reale E (1956) Contributo alla conoscenza delle tra i processi articolari delle vertebre dell’uomo. Archivo Italiano di Anatomia e di Embriologia 61(1):1–16

    CAS  Google Scholar 

  13. Inami S, Kaneoka K, Hayashi K, Ochiai N (2000) Types of synovial fold in the cervical facet joint. J Orthop Sci 5:475–480

    Article  CAS  PubMed  Google Scholar 

  14. Farrell SF, Osmotherly PG, Cornwall J, Rivett DA (2016) Morphology and morphometry of lateral atlantoaxial joint meniscoids. Anat Sci Int 91:89–96. doi:10.1007/s12565-015-0276-z

    Article  PubMed  Google Scholar 

  15. Farrell SF, Osmotherly PG, Cornwall J, Rivett DA (2015) The anatomy and morphometry of cervical zygapophyseal joint meniscoids. Surg Radiol Anat 37(7):799–807. doi:10.1007/s00276-014-1406-3

    Article  PubMed  Google Scholar 

  16. Webb AL, Darekar AA, Sampson M, Rassoulian H (2009) Synovial folds of the lateral atlantoaxial joints: in vivo quantitative assessment using magnetic resonance imaging in healthy volunteers. Spine 34(19):E697–E702. doi:10.1097/BRS.0b013e3181ac8c6d

    Article  PubMed  Google Scholar 

  17. Webb AL, Rassoulian H, Mitchell BS (2012) Morphometry of the synovial folds of the lateral atlanto-axial joints: the anatomical basis for understanding their potential role in neck pain. Surg Radiol Anat 34(2):115–124. doi:10.1007/s00276-011-0834-6

    Article  PubMed  Google Scholar 

  18. Webb AL, Darekar A, Rassoulian H (2011) The influence of age, anthropometrics and range of motion on the morphometry of the synovial folds of the lateral atlanto-axial joints: a pilot study. Eur Spine J 20(4):542–549. doi:10.1007/s00586-010-1553-0

    Article  PubMed  Google Scholar 

  19. Farrell SF, Osmotherly PG, Rivett DA, Cornwall J (2015) Formic acid demineralization does not affect the morphometry of cervical zygapophyseal joint meniscoids. Anat Sci Int 90:57–63. doi:10.1007/s12565-014-0248-8

    Article  CAS  PubMed  Google Scholar 

  20. Kawabe N, Hirotani H, Tanaka O (1989) Pathomechanism of atlantoaxial rotatory fixation in children. J Paediatr Orthop 9:569–574

    Article  CAS  Google Scholar 

  21. Chang H, Found EM, Clark CR, Goel VK, Gang CS (1992) Meniscus-like synovial fold in the atlantoaxial (C1–C2) joint. J Spinal Disord 5(2):227–231

    Article  CAS  PubMed  Google Scholar 

  22. Tang XY, Liu LJ, Yang HJ, Peng MX, Liao SH (2007) Anatomic study of the synovial folds of the occipito-atlanto-axial joints. Clin Anat 20(4):376–381. doi:10.1002/ca.20408

    Article  PubMed  Google Scholar 

  23. Kos J, Hert J, Sevcik P (2002) Meniscoids of the intervertebral joints. Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca 69(3):149–157

    CAS  PubMed  Google Scholar 

  24. Yu S, Sether L, Haughton VM (1987) Facet joint menisci of the cervical spine: correlative MR imaging and cryomicrotomy study. Radiology 164:79–82

    Article  CAS  PubMed  Google Scholar 

  25. Fletcher G, Haughton VM, Ho K, Yu S (1990) Age-related changes in the cervical facet joints: studies with cryomicrotomy, MR and CT. Am J Roentgenol 154(4):817–820

    Article  CAS  Google Scholar 

  26. Inami S, Shiga T, Tsujino A, Okado N, Ochiai N (2001) Immunohistochemical demonstration of nerve fibres in the synovial fold of the human facet joint. J Orthop Res 19:593–596

    Article  CAS  PubMed  Google Scholar 

  27. Cornwall J, Perry GF, Louw G, Stringer MD (2012) Who donates their body to science? An international, multicenter, prospective study. Anat Sci Educ 5(4):208–216

    Article  PubMed  Google Scholar 

  28. Giles LG, Harvey AR (1987) Immunohistochemical demonstration of nociceptors in the capsule and synovial folds of human zygapophyseal joints. Br J Rheumatol 26:362–364

    Article  CAS  PubMed  Google Scholar 

  29. Giles LG, Taylor JR (1987) Human zygapophyseal joint capsule and synovial fold innervation. Br J Rheumatol 26(2):93–98

    Article  CAS  PubMed  Google Scholar 

  30. Gronblad M, Korkala O, Konttinen YT, Nederstrom A, Hukkanen M, Tolvanen E, Polak JM (1991) Silver impregnation and immunohistochemical study of nerves in lumbar facet joint plical tissue. Spine 16(1):34–38

    Article  CAS  PubMed  Google Scholar 

  31. Farrell SF, Osmotherly PG, Cornwall J, Rivett DA (2016) Immunohistochemical investigation of nerve fibre presence and morphology in elderly cervical spine meniscoids. Spine J. doi:10.1016/j.spinee.2016.06.004

    PubMed  Google Scholar 

  32. Haines DM, Chelack BJ (1991) Technical considerations for developing enzyme immunohistochemical staining procedures on formalin-fixed paraffin-embedded tissues for diagnostic pathology. J Vet Diagn Invest 3:101–112

    Article  CAS  PubMed  Google Scholar 

  33. Shi S-R, Key ME, Kalra KL (1991) Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 39(6):741–748

    Article  CAS  PubMed  Google Scholar 

  34. Cornwall J, Mercer S, Harris AJ (2006) Referred pain from the lumbar multifidus. Man Ther 11(1):40–45

    Article  PubMed  Google Scholar 

  35. Aprill C, Axinn MJ, Bogduk N (2002) Occipital headaches stemming from the lateral atlanto-axial(C1–2) joint. Cephalalgia 22(1):15–22

    Article  CAS  PubMed  Google Scholar 

  36. Cooper G, Bailey B, Bogduk N (2007) Cervical zygapophyseal joint pain maps. Pain Med 8(4):344–353. doi:10.1111/j.1526-4637.2006.00201.x

    Article  PubMed  Google Scholar 

  37. Felson DT (2013) Osteoarthritis. In: Imboden J, Hellmann D, Stone J (eds) Current rheumatology diagnosis and treatment, 3rd edn. McGraw-Hill, New York

    Google Scholar 

  38. Kemp WL, Burns DK, Brown TG (2008) Pathology of the bones and joints. In: Kemp W, Burns D, Brown T (eds) Pathology: the big picture. McGraw-Hill, New York

    Google Scholar 

  39. Felson DT (2012) Osteoarthritis. In: Longo D, Fauci A, Kasper D, Hauser S, Jameson J, Loscalzo J (eds) Harrison’s principles of internal medicine, 18th edn. McGraw-Hill, New York

    Google Scholar 

  40. Barr A, Barbe M, Clark B (2004) Work-related musculoskeletal disorders of the hand and wrist: epidemiology, pathophysiology, and sensorimotor changes. J Orthop Sports Phys Ther 34(10):610–627

    Article  PubMed  PubMed Central  Google Scholar 

  41. Bogduk N (2011) On cervical zygapophyseal joint pain after whiplash. Spine 36(25S):S194–S199

    Article  PubMed  Google Scholar 

  42. Kaneoka K, Ono K, Inami S, Hayashi K (1999) Motion analysis of cervical vertebra during whiplash loading. Spine 24:763–770

    Article  CAS  PubMed  Google Scholar 

  43. Grauer JN, Panjabi M, Cholewicki J, Nibu K, Dvorak J (1997) Whiplash produces an S-shaped curvature of the neck with hyperextension at lower levels. Spine 22(21):2489–2494

    Article  CAS  PubMed  Google Scholar 

  44. Schonstrom N, Twomey L, Taylor J (1993) The lateral atlanto-axial joints and their synovial folds: an in vitro study of soft tissue injuries and fractures. J Trauma 35(6):886–892

    Article  CAS  PubMed  Google Scholar 

  45. Taylor JR, Taylor MM (1996) Cervical spine injuries: an autopsy of 109 blunt injuries. J Musculoskelet Pain 4(4):61–79

    Article  Google Scholar 

  46. Barnsley L, Lord SM, Wallis BJ, Bogduk N (1995) The prevalence of chronic cervical zygapophysial joint pain after whiplash. Spine 20(1):20–25

    Article  CAS  PubMed  Google Scholar 

  47. Lord SM, Barnsley L, Wallis BJ, Bogduk N (1996) Chronic cervical zygapophysial joint pain after whiplash: a placebo-controlled prevalence study. Spine 21(15):1737–1744

    Article  CAS  PubMed  Google Scholar 

  48. Lord SM, Barnsley L, Wallis BJ, McDonald GJ, Bogduk N (1996) Percutaneous radio-frequency neurotomy for chronic cervical zygapophyseal joint pain. N Engl J Med 335(23):1721–1726

    Article  CAS  PubMed  Google Scholar 

  49. Yin W, Bogduk N (2008) The nature of neck pain in a private pain clinic in the United States. Pain Medicine 9:196–203

    Article  PubMed  Google Scholar 

  50. Cramer GD, Henderson CN, Little JW, Daley C, Grieve TJ (2010) Zygapophyseal joint adhesions after induced hypomobility. J Manip Physiol Ther 33(7):508–518

    Article  Google Scholar 

  51. Enneking W, Horowitz M (1972) The intra-articular effects of immobilisation of the human knee. J Bone Jt Surg 54:973–985

    Article  CAS  Google Scholar 

  52. Zukschwerdt L, Emminger E, Biedermann F, Zettel H (1955) Wirbelgelenk und Bandscheibe. Hippokrates, Stuttgart

    Google Scholar 

  53. Kos J, Wolf J (1972) Les menisques intervertebraux et leur role possible dans les blocages vertebraux. Annales de Medecine Physique 15:203–218

    Google Scholar 

  54. Bogduk N, Jull G (1985) The theoretical pathology of acute locked back: a basis for manipulative therapy. Man Med 1:78–82

    Google Scholar 

  55. Evans DW (2002) Mechanisms and effects of spinal high-velocity, low-amplitude thrust manipulation: previous theories. J Manip Physiol Ther 25(4):251–262

    Article  Google Scholar 

  56. Khan S, Farrell SF (2016) A unique bilateral variation of lateral atlantoaxial joint meniscoid morphology: case report. Anatomy 10(2):153–155. doi:10.2399/ana.16.026

    Article  Google Scholar 

  57. Sigmund EE, Suero GA, Hu C, McGorty K, Sodickson DK, Wiggins GC, Helpern JA (2012) High-resolution human cervical spinal cord imaging at 7 T. NMR Biomed 25(7):891–899

    Article  CAS  PubMed  Google Scholar 

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Farrell, S.F., Osmotherly, P.G., Cornwall, J. et al. Cervical spine meniscoids: an update on their morphological characteristics and potential clinical significance. Eur Spine J 26, 939–947 (2017). https://doi.org/10.1007/s00586-016-4915-4

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  • DOI: https://doi.org/10.1007/s00586-016-4915-4

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