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Multifocal spinal malignant peripheral nerve sheath tumor in an immunocompromised individual: case report and review of literature

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Abstract

Purpose

Primary intraosseous spinal malignant peripheral nerve sheath tumor (MPNST) is exceedingly rare. MPNST with multifocal origin has been described to occur in the extremities. Such a lesion has not been described to occur in the spine. We describe a case of multifocal spinal MPNST and to review the literature relevant to this rare entity and its management.

Methods

A 40-year-old immunodeficient patient presented with rapidly progressive paraparesis and mid back ache.

Results

Despite aggressive surgical decompression, he developed multiple metastases 3 months after surgery. However, he remained stable for 1 year without any adjuvant therapy. Presently, he has received palliative radiotherapy for spinal recurrence and cerebral metastasis.

Conclusion

Multifocal spinal MPNST is a rare lesion. In this instance, the multifocality of the disease and its odd location could be attributed to the immunodeficiency state. The prolonged survival could be due to an improvement in his immune status due to HAART.

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Conflict of interest

None of the authors has any potential conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER), 2nd Floor, Super Specialty Block, Pondicherry, 605006, India

    V. R. Roopesh Kumar, Venkatesh S. Madhugiri, Gopalakrishnan M. Sasidharan & Sudheer Kumar Gundamaneni

  2. Department of Neurosurgery, Apollo Specialty Hospital, Chennai, India

    C. V. Shankar Ganesh

Authors
  1. V. R. Roopesh Kumar
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  2. Venkatesh S. Madhugiri
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  3. Gopalakrishnan M. Sasidharan
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  4. C. V. Shankar Ganesh
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  5. Sudheer Kumar Gundamaneni
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Corresponding author

Correspondence to V. R. Roopesh Kumar.

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Roopesh Kumar, V.R., Madhugiri, V.S., Sasidharan, G.M. et al. Multifocal spinal malignant peripheral nerve sheath tumor in an immunocompromised individual: case report and review of literature. Eur Spine J 23 (Suppl 2), 236–241 (2014). https://doi.org/10.1007/s00586-013-3103-z

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  • DOI: https://doi.org/10.1007/s00586-013-3103-z

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