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Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population

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Abstract

Purpose

To investigate whether rs11190870 near LBX1 correlates with the susceptibility or curve progression of adolescent idiopathic scoliosis (AIS) in a Han Chinese population.

Methods

A total of 949 AIS patients and 976 age-matched healthy controls were recruited. All the subjects were genotyped using the PCR-based invader assay. Case–control study and case-only study were performed to define the contribution of rs11190870 to predisposition and curve severity of AIS. Additionally, we further conducted a meta-analysis of the study findings together with those of previously reported studies.

Results

A significant association of rs11190870 with AIS was observed in the Han Chinese population (P = 1.8 × 10−9; odd ratio = 1.51; 95 % confidence interval = 1.33–1.71), and AIS patients with TT genotype had a larger Cobb angle than those with TC or CC genotype (P = 0.005). The meta-analysis confirmed that the positive association of this SNP with AIS in the East Asian population.

Conclusions

The SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of AIS.

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Acknowledgments

This work was supported by the Natural Science Foundation of China (30901570) (81171767). The Manuscript submitted does not contain information about medical device(s)/drug(s). No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

Conflicts of interest

None.

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Authors and Affiliations

  1. Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road No 321, 210008, Nanjing, China

    Hua Jiang, Xusheng Qiu, Huang Yan, Zezhang Zhu, Bangping Qian & Yong Qiu

  2. Department of Orthopedic Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road No 321, 210008, Nanjing, China

    Jin Dai

Authors
  1. Hua Jiang
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  2. Xusheng Qiu
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  3. Jin Dai
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  4. Huang Yan
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  5. Zezhang Zhu
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  6. Bangping Qian
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  7. Yong Qiu
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Corresponding author

Correspondence to Yong Qiu.

Additional information

H. Jiang, X. Qiu and J. Dai contributed equally to this work.

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Jiang, H., Qiu, X., Dai, J. et al. Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population. Eur Spine J 22, 282–286 (2013). https://doi.org/10.1007/s00586-012-2532-4

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  • DOI: https://doi.org/10.1007/s00586-012-2532-4

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