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Transcranial motor-evoked potentials monitoring can detect spinal cord ischemia more rapidly than spinal cord-evoked potentials monitoring during aortic occlusion in rats

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Abstract

In this study, we evaluated the efficacy of transcranial motor-evoked potentials (tc-MEPs), compared with segmental spinal cord-evoked potentials (SCEPs), for detecting spinal cord ischemia (SCI) and assessed the relationship between neurological outcome and tc-MEPs or SCEPs in the rat aortic occlusion model. In the rats, SCI was induced by aortic occlusion for 10 min with a balloon catheter. At first, tc-MEPs (Group A: n = 6) or segmental SCEPs (Group B: n = 6) was recorded during SCI. Second, in using the quantal bioassay for the relationship between an interval of aortic occlusion and the probability of positive response in tc-MEPs or segmental SCEPs, the P50MEP and P50SCEP which represent the interval of aortic occlusion associated with 50% probability of assessment of ischemic spinal cord dysfunction by tc-MEP and SCEP were analyzed. The amplitude of tc-MEPs decreased significantly at 30 s and disappeared completely at 2 min after aortic occlusion. In Group B, it took about 6 min after aortic occlusion to diminish SCEP signal amplitude by approximately 50%. P50MEP obtained in the quantal analysis was 0.3 ± 0.1 min. P50SCEP was calculated as 6.2 ± 0.5 min that was significantly (P < 0.01) longer than P50MEP. Our data indicated that tc-MEP monitoring could detect the onset of SCI so rapidly in comparison with segmental SCEP monitoring, which could provide therapeutic windows in a surgical approach that includes spinal cord protection.

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Acknowledgments

This study was performed under the support of the Grant-in-aid for Scientific Research from the Ministry of Education of Japan (No. 16591551, 17591479).

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Authors and Affiliations

  1. Department of Anesthesiology, University of the Ryukyus, Nishihara, Okinawa, Japan

    Manabu Kakinohana, Seiya Nakamura, Tatsuya Fuchigami & Kazuhiro Sugahara

Authors
  1. Manabu Kakinohana
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  2. Seiya Nakamura
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  3. Tatsuya Fuchigami
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  4. Kazuhiro Sugahara
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Correspondence to Manabu Kakinohana.

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Kakinohana, M., Nakamura, S., Fuchigami, T. et al. Transcranial motor-evoked potentials monitoring can detect spinal cord ischemia more rapidly than spinal cord-evoked potentials monitoring during aortic occlusion in rats. Eur Spine J 16, 787–793 (2007). https://doi.org/10.1007/s00586-006-0165-1

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  • DOI: https://doi.org/10.1007/s00586-006-0165-1

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