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Field effect transistor with integrated microfluidic channel as pH sensor

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Abstract

This paper presents an original design of chemical sensors with an integrated microfluidic channel. Targeted applications are pH-meters devices. The integration of the microfluidic channel allows decreasing the volume required for each measurement. The sensing part of the device consists of a field effect transistor (FET) with a suspended gate directly performed above the fluidic channel. Chemicals under test are driven through the sensing area between the electrical channel of the FET and the suspended gate. By this way products that flow in the microfluidic channel directly module the concentration of charges inside the transistor’s gap and thus induce changes in the transfer characteristic. This paper describes the fabrication process and the technological choices for materials. Electrical tests, performed in air and in liquid, have shown a good behavior of the transistor, linked to a good mechanical sustain of the fluidic channel. The system is able to detect transition between air and liquid media. Moreover, it has shown a high sensitivity (about 300 mV/pH) to pH measurements.

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References

  • Batista PD, Mulato M (2005) ZnO extended-gate field-effect transistors as pH sensors. Appl Phys Lett 87:143508

    Article  Google Scholar 

  • Bergveld P (1970) Development of an ion sensitive solid-state device for neuro-physiological measurements. IEEE Trans Biomed Eng 17:70–71

    Article  Google Scholar 

  • Bergveld P (2003) Thirty years of ISFETOLOGY—what happened in the past 30 years and what may happen in the next 30 years. Sensor Actuator B-Chem 88:1–20

    Article  Google Scholar 

  • Chi LL, Chou JC, Chung WY, Sun TP, Hsiung SK (2000) Study on extended gate field effect transistor with tin oxide sensing membrane. Mater Chem Phys 63:19–23

    Article  Google Scholar 

  • Chin YL, Chou J-C, Lei ZC, Sun T-P, Chung WY, Hsiung S-K (2001) Titanium nitride membrane application to the extended gate field effect transistor pH sensor using VLSI technology. Jpn J Appl Phys 40:6411–6415

    Article  Google Scholar 

  • da Silva Rodrigues B, De Sagazan O, Crand S, Mohammed-Brahim T, Morimoto N (2011) pH meter based in suspended gate field effect transistors to application in monitoring of water quality. ECS Trans Optoelectron Sens 39(1):291–298

    Article  Google Scholar 

  • De Sagazan O, Harnois M, Girard A, Le Bihan F, Salaun AC, Crand S, Mohammed-Brahim T (2008) Direct electrical detection of biological species. ECS Trans Microelectron Technol Dev 14(1):3–10

    Google Scholar 

  • Errachid A, Bausells J, Jaffrezic-Renault N (1999) A simple REFET for pH detection in differential mode. Sens Actuators B Chem 60(1):43–48

    Article  Google Scholar 

  • Girard A, De Sagazan O, Le Bihan F, Mohammed-Brahim T, Geneste F, Brissot P, Guguen-Guillouzo C (2008) Electrical Detection of very low content of transferrin in view of iron metabolism characterization. ICST 2008, international conference on sensing technology, Tainan, Taiwan, 30 Nov to 3 Dec 2008, proc pp 637–641

  • Harnois M, De Sagazan O, Salaün A-C, Mohammed-Brahim T, Bezieau S (2008) Electronic detection of genetic mutation using suspended-gate transistor: application to clinical diagnostic. In: Proceeding p1.108, Biosensors 2008, Shanghai, Chine, 14–16 Mar 2008

  • Humenyuk I, Torbiero B, Assie-Souleille S, Colin R, Dollat X, Franc B, Martinez A, Temple-Boyer P (2006) Development of pNH4-ISFETs microsensors for water analysis. Microelectron J 37(6):475–479

    Article  Google Scholar 

  • Janata J (1983) Electrochemistry of chemically sensitive field effect transistors. Sens Actuators 4:255–265

    Article  Google Scholar 

  • Janata J (1994) 20 years of ion selective field effect transistors. Analyst 119:2275–2278

    Article  Google Scholar 

  • Jimenez-Jorquera C, Orozco J, Baldi A (2010) ISFET based microsensors for environmental monitoring. Sensors 10:61–83

    Article  Google Scholar 

  • Kherrat A, Le Bihan F, Razan F, Coulon N, Griscom L, De Sagazan O, Crand S, Mohammed-Brahim T (2010) pH micro-sensors associated with micro-fluidics for chemical analysis. ECS Trans Chem Sens 9 33(8):153–159

    Article  Google Scholar 

  • Mohammed-Brahim T, Salaün A-C, Le Bihan F (2008) SGFET as charge sensor: application to chemical and biological species detection. Sens Trans J 900:11–26

    Google Scholar 

  • Salaün A-C, Le Bihan F, Mohammed-Brahim T (2011) Modeling the high pH sensitivity of suspended gate field effect transistor (SGFET). Sens Actuators B 158(2011):138–143

    Article  Google Scholar 

  • Shi Z, Dazhong Z (2009) Modeling and discussion of threshold voltage for a multi-floating gate FET pH sensor. J Semicond 30(11):1–4

    Google Scholar 

  • Whitesides GM, Ostuni E, Takayama S, Jiang X, Ingber DE (2001) Soft lithography in biology and biochemistry. Annu Rev Biomed Eng 3:335–373

    Article  Google Scholar 

  • Yates DE, Levine S, Healy TW (1808) Site-binding model of the electrical double layer at the oxide/water interface. J Chem Soc Faraday Trans I 1974:70

    Google Scholar 

  • Zhao XM, Xia YN, Whitesides GM (1997) Soft lithographic methods for nano-fabrication. J Mater Chem 7:1069–1074

    Article  Google Scholar 

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Correspondence to F. Le Bihan.

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Bouhadda, I., De Sagazan, O. & Le Bihan, F. Field effect transistor with integrated microfluidic channel as pH sensor. Microsyst Technol 21, 289–294 (2015). https://doi.org/10.1007/s00542-014-2125-8

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  • DOI: https://doi.org/10.1007/s00542-014-2125-8

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