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Risk factors for lymphatic and venous involvement in endoscopically resected gastric cancer

  • Original Article—Alimentary Tract
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Abstract

Background

Lymphatic and venous involvement is a critical factor in the curability assessment of endoscopically resected gastric cancers; however, the risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers remain unknown.

Methods

To identify risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers, we retrospectively reviewed a consecutive series of 1229 endoscopically resected gastric cancers in 1083 patients treated between January 2009 and December 2011.

Results

Lymphatic and venous involvement was detected in 57 (4.6 %) and 32 (2.6 %) lesions, respectively. A multivariate analysis identified a larger tumor size, deeper invasion (submucosal invasion or deeper), and the presence of a papillary or an undifferentiated-type adenocarcinoma component as independent risk factors for lymphatic involvement. As for venous involvement, deeper invasion (≥500 μm submucosal invasion), a macroscopically elevated type, and the presence of an undifferentiated-type adenocarcinoma component were identified as independent risk factors.

Conclusions

The present study identified the independent risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers. The recognition of these risk factors would help in the selection of lesions that may require a particularly careful histological evaluation.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan

    Masau Sekiguchi, Ichiro Oda, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga & Yutaka Saito

  2. Molecular Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Shigeki Sekine

  3. Pathology Division, National Cancer Center Hospital, Tokyo, Japan

    Hirokazu Taniguchi, Hitoshi Tsuda & Ryoji Kushima

Authors
  1. Masau Sekiguchi
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  2. Shigeki Sekine
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  3. Ichiro Oda
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  4. Satoru Nonaka
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  5. Haruhisa Suzuki
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  6. Shigetaka Yoshinaga
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  7. Hirokazu Taniguchi
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  8. Hitoshi Tsuda
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  9. Ryoji Kushima
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  10. Yutaka Saito
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Correspondence to Shigeki Sekine.

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Sekiguchi, M., Sekine, S., Oda, I. et al. Risk factors for lymphatic and venous involvement in endoscopically resected gastric cancer. J Gastroenterol 48, 706–712 (2013). https://doi.org/10.1007/s00535-012-0696-7

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  • DOI: https://doi.org/10.1007/s00535-012-0696-7

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