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Analysis of the clinical features of recurrent acute pancreatitis in China

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Abstract

Background

Since few systematic studies have focused on recurrent acute pancreatitis in China, we sought to investigate its clinical features, including etiological factors and relative frequency.

Methods

Patients were selected from a total 1471 patients with acute pancreatitis in ten cities of China. All had been admitted to a hospital with an attack of acute pancreatitis between January 1992 and December 2002. Data for each patient was recorded on a standardized form.

Results

Of the 1471 patients with acute pancreatitis, 157 (10.7%) had recurrent acute pancreatitis. The majority (63%) were male, with a mean age of 41 years (range, 13–82 years). Regarding the etiology, alcohol (20.4%) and cholelithiasis (20.4%) were the most frequent causes, followed by diet (13.4%), hypertriglyceridemia (8.3%), biliary tract infection (5.7%), other (5.1%), and idiopathic factors (26.8%). Alcohol was most frequent in male patients (30.3%), whereas cholelithiasis was most frequent (34.5%) in female patients. The majority of patients (79.6%) presented with their second attack of pancreatitis. Complications of recurrent acute pancreatitis in order of frequency were pancreatic pseudocyst, multiple organ failure, diabetes mellitus type 2, and shock.

Conclusions

Recurrent acute pancreatitis remains a frequent disease, with cholelithiasis and alcohol being the most usual etiological factors. Alcohol is the primary etiological factor in male patients. In about 26.8% of cases, the etiology remains unknown.

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References

  1. J Toouli M Brooke-Smith C Bassi D Carr-Locke J Telford P Freeny C Imrie R Tandon (2002) ArticleTitleGuidelines for the management of acute pancreatitis J Gastroenterol Hepatol 17 IssueIDSuppl s1 15–24 10.1046/j.1440-1746.17.s1.2.x Occurrence Handle10.1046/j.1440-1746.17.s1.2.x

    Article  Google Scholar 

  2. InstitutionalAuthorNameBritish Society of Gastroenterology (1998) ArticleTitleUnited Kingdom Guidelines for the management of acute pancreatitis Gut 42 IssueIDSuppl 2 1–3

    Google Scholar 

  3. G Read JM Braganza HR Howat (1976) ArticleTitlePancreatitis: a retrospective study Gut 17 945–52 Occurrence Handle10.1136/gut.17.12.945 Occurrence Handle1:STN:280:DyaE2s7hslWksQ%3D%3D Occurrence Handle1017714

    Article  CAS  PubMed  Google Scholar 

  4. W Uhl R Isenmann G Curti R Vogel HG Beger MW Buchler (1996) ArticleTitleInfluence of etiology on the course and outcome of acute pancreatitis Pancreas 13 335–43 10.1097/00006676-199611000-00002 Occurrence Handle10.1097/00006676-199611000-00002 Occurrence Handle1:STN:280:DyaK2s%2FlsFGjtA%3D%3D Occurrence Handle8899793

    Article  CAS  PubMed  Google Scholar 

  5. L Gullo M Migliori A Oláh G Farkas P Levy C Arvanitakis P Lankisch H Beger (2002) ArticleTitleAcute pancreatitis in five European countries. Etiology and mortality Pancreas 24 223–7 10.1097/00006676-200204000-00003 Occurrence Handle10.1097/00006676-200204000-00003 Occurrence Handle11893928

    Article  PubMed  Google Scholar 

  6. MC Chen (1986) ArticleTitleDiet-induced pancreatitis in China J Clin Gastroenterol 8 611–2 Occurrence Handle1:STN:280:DyaL2s7htVCktQ%3D%3D Occurrence Handle3805654 Occurrence Handle10.1097/00004836-198612000-00003

    Article  CAS  PubMed  Google Scholar 

  7. SR Thomson WS Hendry GA McFarlane AI Davidson (1987) ArticleTitleEpidemiology and outcome of acute pancreatitis Br J Surg 74 398–401 Occurrence Handle10.1002/bjs.1800740526 Occurrence Handle1:STN:280:DyaL2s3ktlaisA%3D%3D Occurrence Handle3594136

    Article  CAS  PubMed  Google Scholar 

  8. HQ Tao JX Zhang SC Zou (2004) ArticleTitleClinical characteristics and management of patients with early acute severe pancreatitis: experience from a medical center in China World J Gastroenterol 10 919–21 Occurrence Handle15040047

    PubMed  Google Scholar 

  9. L Gullo M Migliori R Pezzilli A Olah G Farkas P Levy et al. (2002) ArticleTitleAn update on recurrent acute pancreatitis: data from five European countries Am J Gastroenterol 97 1959–62 10.1111/j.1572-0241.2002.05907.x Occurrence Handle10.1111/j.1572-0241.2002.05907.x Occurrence Handle12190160

    Article  PubMed  Google Scholar 

  10. LM Peterson JJ Collins RE Wilson (1968) ArticleTitleAcute pancreatitis occurring after operation Surg Gynecol Obstet 127 23–8 Occurrence Handle1:STN:280:DyaF1czhtV2iug%3D%3D Occurrence Handle5657779

    CAS  PubMed  Google Scholar 

  11. AP Corfield MJ Cooper RCN Williamson (1985) ArticleTitleAcute pancreatitis: a lethal disease of increasing incidence Gut 26 724–9 Occurrence Handle10.1136/gut.26.7.724 Occurrence Handle1:STN:280:DyaL2M3lvFWgug%3D%3D Occurrence Handle4018637

    Article  CAS  PubMed  Google Scholar 

  12. S Bank A Indaram (1999) ArticleTitleCauses of acute and recurrent pancreatitis. Clinical considerations and clues to diagnosis Gastroenterol Clin North Am 28 571–89 10.1016/S0889-8553(05)70074-1 Occurrence Handle10.1016/S0889-8553(05)70074-1 Occurrence Handle1:STN:280:DyaK1Mvjt1Omtw%3D%3D Occurrence Handle10503137

    Article  CAS  PubMed  Google Scholar 

  13. MZ Chen HS Yang QF Xu ZD Zhang YL Cai (1984) ArticleTitleAcute pancreatitis in Suzhou area. Predisposing causes and natural history Chin Med J (Engl) 97 747–50 Occurrence Handle1:STN:280:DyaL28%2FgtlOhug%3D%3D

    CAS  Google Scholar 

  14. M Schiertroma R Lattanzio A Risetti R Di Placido F Carlei S Leardi et al. (1999) ArticleTitleTreatment of acute biliary pancreatitis in the aged in the endolaparoscopic era Minerva Chir 54 677–84

    Google Scholar 

  15. W Steinberg S Tenner (1994) ArticleTitleAcute pancreatitis N Engl J Med 330 1198–210 10.1056/NEJM199404283301706 Occurrence Handle10.1056/NEJM199404283301706 Occurrence Handle1:STN:280:DyaK2c7oslyitg%3D%3D Occurrence Handle7811319

    Article  CAS  PubMed  Google Scholar 

  16. GH Sakorafas AG Tsiotou (2000) ArticleTitleEtiology and pathogenesis of acute pancreatitis. Current Concepts J Clin Gastroenterol 30 343–56 10.1097/00004836-200006000-00002 Occurrence Handle10.1097/00004836-200006000-00002 Occurrence Handle1:STN:280:DC%2BD3M%2FhsFKjsA%3D%3D Occurrence Handle10875461

    Article  CAS  PubMed  Google Scholar 

  17. L Somogyi SP Martin T Venkatesan CD Ulrich Suffix2nd (2001) ArticleTitleRecurrent acute pancreatitis: an algorithmic approach to identification and elimination of inciting factors Gastroenterology 120 708–17 10.1053/gast.2001.22333 Occurrence Handle10.1053/gast.2001.22333 Occurrence Handle1:STN:280:DC%2BD3M7lvV2mtA%3D%3D Occurrence Handle11179245

    Article  CAS  PubMed  Google Scholar 

  18. W Zhang H-C Shan Y Gu (2005) ArticleTitleRecurrent acute pancreatitis and its relative factors World J Gastroenterol 11 3002–4 Occurrence Handle15902746

    PubMed  Google Scholar 

  19. PA Testoni S Caporuscio F Bagnolo F Lella (2000) ArticleTitleIdiopathic recurrent pancreatitis: long-term results after ERCP, endoscopic sphincterotomy, or ursodeoxycholic acid treatment Am J Gastroenterol 95 1702–7 10.1111/j.1572-0241.2000.02292.x Occurrence Handle10.1111/j.1572-0241.2000.02292.x Occurrence Handle1:STN:280:DC%2BD3cvgvVWmsA%3D%3D Occurrence Handle10925971

    Article  CAS  PubMed  Google Scholar 

  20. E Ros S Navarro C Bru A Garcia-Puges R Valderrama (1991) ArticleTitleOccult microlithiasis in idiopathic acute pancreatitis: prevention of relapses by cholecystectomy or ursodeoxycholic acid therapy Gastroenterology 101 1701–9 Occurrence Handle1:STN:280:DyaK38%2FmsVajtQ%3D%3D Occurrence Handle1955135

    CAS  PubMed  Google Scholar 

  21. SP Lee JF Nicholls HZ Park (1992) ArticleTitleBiliary sludge as a cause of acute pancreatitis N Engl J Med 326 589–93 Occurrence Handle1:STN:280:DyaK387jtFSktw%3D%3D Occurrence Handle1734248 Occurrence Handle10.1056/NEJM199202273260902

    Article  CAS  PubMed  Google Scholar 

  22. JM Chebli AP Ferrari Junior MR Silva DR Borges AN Arallah MM das Neves (2000) ArticleTitleBiliary microcrystals in idiopathic acute pancreatitis: clue for occult underlying biliary etiology Arq Gastroenterol 37 93–101 Occurrence Handle1:STN:280:DC%2BD3M%2Fps1yhsw%3D%3D Occurrence Handle11144021

    CAS  PubMed  Google Scholar 

  23. VK Parasher K Romain R Sukumar J Jordan (2000) ArticleTitleCan ERCP contrast agents cause pseudomicrolithiasis? Their effect on the final outcome of bile analysis on patients with suspected microlithiasis Gastrointest Endosc 51 IssueID4 pt 1 401–4 10.1016/S0016-5107(00)70438-X Occurrence Handle10.1016/S0016-5107(00)70438-X Occurrence Handle1:STN:280:DC%2BD3c3gvFajuw%3D%3D Occurrence Handle10744809

    Article  CAS  PubMed  Google Scholar 

  24. M Tandon M Topazian (2001) ArticleTitleEndoscopic ultrasound in idiopathic acute pancreatitis Am J Gastroenterol 96 705–9 10.1111/j.1572-0241.2001.03609.x Occurrence Handle10.1111/j.1572-0241.2001.03609.x Occurrence Handle1:STN:280:DC%2BD3M7ovFOksg%3D%3D Occurrence Handle11280538

    Article  CAS  PubMed  Google Scholar 

  25. GA Lehman (2003) ArticleTitleAcute recurrent pancreatitis Can J Gastroenterol 17 381–3 Occurrence Handle12813605

    PubMed  Google Scholar 

  26. CL Liu CM Lo JK Chan RT Poon ST Fan (2000) ArticleTitleEUS for detection of occult cholelithiasis in patients with idiopathic pancreatitis Gastrointest Endosc 51 28–32 10.1016/S0016-5107(00)70382-8 Occurrence Handle10.1016/S0016-5107(00)70382-8 Occurrence Handle1:STN:280:DC%2BD3c%2Fpt1Oqsw%3D%3D Occurrence Handle10625791

    Article  CAS  PubMed  Google Scholar 

  27. ST Fan EC Lai FP Mok CM Lo SS Zheng J Wong (1993) ArticleTitleEarly treatment of acute biliary pancreatitis by endoscopic papillotomy N Engl J Med 328 228–32 10.1056/NEJM199301283280402 Occurrence Handle10.1056/NEJM199301283280402 Occurrence Handle1:STN:280:DyaK3s7hs1yisw%3D%3D Occurrence Handle8418402

    Article  CAS  PubMed  Google Scholar 

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Gao, Y., Li, Y., Wang, Q. et al. Analysis of the clinical features of recurrent acute pancreatitis in China. J Gastroenterol 41, 681–685 (2006). https://doi.org/10.1007/s00535-006-1820-3

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  • DOI: https://doi.org/10.1007/s00535-006-1820-3

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