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Association of the rs3917647 polymorphism of the SELP gene with malnutrition in gastric cancer

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Abstract  

Background

Malnutrition and cachexia are common syndromes in patients with gastric cancer (GC) and are associated with poor quality of life and poor disease prognosis. However, there is still a lack of molecular factors that can predict malnutrition or cachexia in cancer. Studies have shown that among the potential contributors to the development of cancer cachexia, the level of the inflammatory response to P-selectin is regulated by single nucleotide polymorphisms (SNPs) located in the promoter region of the SELP gene. The aim of this study was to evaluate the association between the single nucleotide polymorphism (SNP)-2028 A/G of the SELP gene and malnutrition in patients receiving chemotherapy for gastric cancer (GC).

Methods

The study group consisted of 220 GC patients treated with chemotherapy at Jinhua Municipal Central Hospital. DNA was extracted from peripheral leukocytes of whole blood samples using an animal DNA extraction kit. DNA was amplified using a 1.1 × T3 Super PCR mix, and loci corresponding to the peaks were genotyped using SNP1 software.

Results

Patients carrying the A allele had a reduced risk of developing malnutrition compared to patients with the GG genotype (P < 0.001; OR = 3.411; 95% CI = 1.785–6.516). In addition, multivariate analysis indicated that the AA genotype significantly (more than 16-fold) reduced the risk of developing malnutrition (P < 0.001; OR = 0.062; 95% CI = 0.015–0.255).

Conclusion

SELP -2028A/G SNP may be a useful marker for assessing the risk of malnutrition in GC patients.

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Data availability

The raw data supporting the conclusion of this article will be provided upon request by the authors.

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Acknowledgements

The authors’ special thanks go to all the gastric cancer patients who participated in this study. They also thank the staff at Department of Gastrointestinal Surgery, Department of Hepatobiliary and Pancreatic Surgery, and Department of Medical Oncology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine (Jinhua Municipal Central Hospital).

Funding

This study was supported by the General Project of Zhejiang Province Medical Science and Technology Plan (2021KY1181), the Explore Public Welfare Project of Zhejiang Province Natural Science Foundation (LTGY23H160026), the Foundation of the Science and Technology Department of Jinhua (2021–3-066) and Jinhua Municipal Central Hospital Foundation (JY2020-5–03).

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Author notes

  1. Liang Fu and Changzhen Lei contributed equally to this work.

Authors and Affiliations

  1. Department of Nursing, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China

    Liang Fu, Yingxun Chen, Xiaoqian Xu, Bei Wu, Liping Dong, Xianghong Ye & Lushan Zheng

  2. Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China

    Liang Fu

  3. Department of Gastrointestinal Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China

    Changzhen Lei & Daojun Gong

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Contributions

LF designed the study. LF, YC, XX, BW and LD collected the primary data. CL and LF wrote the manuscript. LZ, DG and XY reviewed statistical analysis, editing, and reviewed of dissertation and journal manuscript. All authors contributed to the article and approved the submitted version.

Corresponding authors

Correspondence to Lushan Zheng or Daojun Gong.

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Ethics

This study was reviewed and approved by Medical Ethics Committee of Jinhua Municipal Central Hospital and all methods were performed in accordance to the Declaration of Helsinki. All data were collected anonymously following informed consent, and participation was voluntary.

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The authors declare no competing interests.

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Fu, L., Lei, C., Chen, Y. et al. Association of the rs3917647 polymorphism of the SELP gene with malnutrition in gastric cancer. Support Care Cancer 31, 708 (2023). https://doi.org/10.1007/s00520-023-08161-z

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