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Effects of PC6 acupressure on acute and delayed nausea and vomiting induced by chemotherapy in patients with malignant neoplasm: a meta-analysis

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Abstract

Objective

Evaluating the intervention effect of PC6 acupressure on chemotherapy-induced acute, delayed nausea, and vomiting in malignant tumor patients.

Method

Eleven databases had been retrieved from January 2010 through January 2022. The published meta-analysis literature was hand-searched, and the language was limited to English and Chinese. The protocol of this meta-analysis was registered with PROSPERO (registration number: CRD42022323693). Two reviewers independently selected relevant eligible articles, extracted data, and evaluated the risk of bias. Meta-analysis was statistically analyzed using software RevMan 5.3.

Result

Ten randomized controlled trials with 975 patients were included. Only two studies were assessed as high quality; eight studies were evaluated as moderate. Meta-analysis showed that compared with the control group, PC6 acupressure reduced the occurrence number of acute (SMD = −0.39,95CI (−0.73, −0.05) P = 0.02), delayed (SMD = −0.51, 95% CI (−0.96, −0.05) P = 0.03) nausea and acute (SMD = −0.42,95% CI (−0.79, −0.06) P = 0.02), delayed (SMD = −0.37, 95% CI (−0.77, 0.03) P = 0.07) vomiting; it reduced the severity of acute (SMD = −0.34, 95% CI (−0.57, −0.11) P = 0.004), delayed (SMD = −0.79, 95% CI (−1.33, −0.25) P = 0.004) nausea and acute (SMD = −0.51, 95% CI (−0.79, −0.23) P = 0.0004), delayed (SMD = −0.50, 95% CI (−0.84, −0.17) P = 0.003) vomiting, while it did not reduced the experience time on acute and delayed CINV.

Conclusion

The meta-analysis shows the effectiveness of PC6 acupressure in preventing and treating nausea and vomiting. Large, high-quality, well-designed randomized controlled trials are needed in the future to determine the efficacy of PC6 acupressure on chemotherapy-induced nausea and vomiting.

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Abbreviations

CINV:

Chemotherapy-induced nausea and vomiting

NK1:

Neurokinin 1

HEC:

High emetic chemotherapy

MEC:

Moderate emetic chemotherapy

CBM:

China Biology Medicine

CNKI:

Chinese National Knowledge Infrastructure

VIP:

Chinese Technical Periodicals

RCT:

Randomized controlled trial

SMD:

Standardized mean difference

VAS:

Visual analog scale

INVR:

Index of Nausea, Vomiting, and Retching

NCCN:

National Comprehensive Cancer Network

PC6:

Pericardium 6

ST36:

Zusanli

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Funding

This work was supported by the Philosophy and Social Science Research Project of Jiangsu Provincial Department of Education (2020SJA1073), the Science and Technology Project of Xuzhou Municipal Health Committee (XWKYHT20220148), the College-level Scientific Research Project of the Affiliated Hospital of Xuzhou Medical University (2021ZB13), and the Science and Technology Development Fund of The Affiliated Hospital of Xuzhou Medical University (XYFM2021003).

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Authors and Affiliations

  1. Xuzhou Medical University, Xuzhou, JiangSu, China

    Chenbing Xiao, Ming Qin & Huiling Xia

  2. Affiliated Hospital of Xuzhou Medical University, Xuzhou, JiangSu, China

    Qianqian Xing, Dan Wang & Weiwei Qian

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  1. Chenbing Xiao
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  2. Ming Qin
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  3. Huiling Xia
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  4. Qianqian Xing
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Contributions

The conception and design of the review: Xiao Chenbing, Qin Ming, Xia Huiling, Qian Weiwei, Xing Qianqian, Wang Dan. Literature retrieval: Xiao Chenbing, Qin Ming. Literature screening: Xiao Chenbing, Qin Ming, Xia Huiling. Quality assessment: Xiao Chenbing, Qin Ming, Xia Huiling. Data analysis: Xiao Chenbing, Qin Ming. Writing – original draft: Xiao Chenbing. Writing – review and editing: Xiao Chenbing, Qin Ming, Xia Huiling, Qian Weiwei, Xing Qianqian, Wang Dan. All authors read and approved the manuscript.

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Correspondence to Weiwei Qian.

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Xiao, C., Qin, M., Xia, H. et al. Effects of PC6 acupressure on acute and delayed nausea and vomiting induced by chemotherapy in patients with malignant neoplasm: a meta-analysis. Support Care Cancer 31, 510 (2023). https://doi.org/10.1007/s00520-023-07976-0

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