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Preoperative nonmedical predictors of functional impairment after brain tumor surgery

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Abstract

Purpose

To identify the preoperative nonmedical predictors of functional impairment after brain tumor surgery.

Methods

Patients were evaluated before brain tumor surgery and after 3 months. The cognitive evaluation included MOCA for the general cognitive status, TMT for attention and executive functions, ROWL-IR and ROWL-DR for memory, and the F-A-S for verbal fluency. Anxiety, depression, social support, resilience, personality, disability, and quality of life were evaluated with the following patient-reported outcome measures (PROMs): HADS, OSS-3, RS-14, TIPI, WHODAS-12, and EORTC-QLQ C30. Functional status was measured with KPS. Regression analyses were performed to identify preoperative nonmedical predictors of functional impairment; PROMs and cognitive tests were compared with the normative values.

Results

A total of 149 patients were enrolled (64 glioma; 85 meningioma). Increasing age, lower education, higher disability, and lower ROWL-DR scores were predictors of functional impairment in glioma patients while higher TMT scores and disability were predictors in meningioma patients. In multiple regression, only a worse performance in TMT remains a predictor in meningioma patients. Cognitive tests were not significantly worse than normative values, while psychosocial functioning was impaired.

Conclusion

TMT could be used in the preoperative evaluation and as a potential predictor in the research field on outcome predictors. Psychosocial functioning should be studied further and considered in a clinical context to identify who need major support and to plan tailored interventions.

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Data availability

The data that support the findings of this study are available from the corresponding author, SS, upon reasonable request.

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Funding

Silvia Schiavolin is supported by a grant from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C. Besta, Linea 4—Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche).

Author information

Authors and Affiliations

Authors

Contributions

Silvia Schiavolin contributed to the acquisition, analysis and interpretation of data, and drafting of the manuscript, and she will act as the overall guarantor. Arianna Mariniello, Morgan Broggi, Francesco DiMeco, and Paolo Ferroli participated in the data acquisition and interpretation; Paolo Ferroli, Matilde Leonardi, and Morgan Broggi contributed to the concept and design of the project. All authors contributed to the revision of the manuscript and approved the final version for submission.

Corresponding author

Correspondence to Silvia Schiavolin.

Ethics declarations

Ethics approval

Approval was obtained from the Institutional Ethical Committee of Fondazione IRCCS Istituto Neurologico Carlo Besta.

Consent to participate

Informed consent was obtained from all individual participants included in the study.

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Patients signed informed consent regarding publishing their data.

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The authors declare no competing interests.

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Supplementary Information

Below is the link to the electronic supplementary material.

520_2021_6732_MOESM1_ESM.docx

Supplementary file1 Results of the univariate linear regression on preoperative predictors of KPS change after 3 months from surgery in patients with glioma. ROWL, IR, 15 Rey-Osterrieth Word List immediate recall; ROWL, DR, 15 Rey-Osterrieth Word List delayed recall; TMT, Trail Making Test; MOCA, Montreal Cognitive Assessment; WHODAS-12, 12 item World Health Organization Disability Assessment Schedule; HADS, Hospital Anxiety and Depression Scale; OSS-3, Oslo-3 Social Support Scale; TIPI, Ten Item Personality Inventory; RS-14, 14-item Resilience Scale; EORTC QLQ-C30, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. (DOCX 16 KB)

520_2021_6732_MOESM2_ESM.docx

Supplementary file2 Results of the univariate linear regression on preoperative predictors of KPS change after 3 months from surgery in patients with meningioma. ROWL, IR, 15 Rey-Osterrieth Word List immediate recall; ROWL, DR, 15 Rey-Osterrieth Word List delayed recall; TMT, Trail Making Test; MOCA, Montreal Cognitive Assessment; WHODAS-12, 12 item World Health Organization Disability Assessment Schedule; HADS, Hospital Anxiety and Depression Scale; OSS-3, Oslo-3 Social Support Scale; TIPI, Ten Item Personality Inventory; RS-14, 14-item Resilience Scale; EORTC QLQ-C30, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. (DOCX 16 KB)

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Schiavolin, S., Mariniello, A., Broggi, M. et al. Preoperative nonmedical predictors of functional impairment after brain tumor surgery. Support Care Cancer 30, 3441–3450 (2022). https://doi.org/10.1007/s00520-021-06732-6

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