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Effects of synbiotic supplementation on serum adiponectin and inflammation status of overweight and obese breast cancer survivors: a randomized, triple-blind, placebo-controlled trial

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Abstract

Purpose

Adipokines and inflammatory factors can affect breast cancer (BC) prognosis and recurrence among breast cancer survivors (BCSs). This study was to evaluate the effects of synbiotic supplementation along with a low-calorie diet on some recurrence-related factors such as adiponectin, tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) among obese and overweight BCSs.

Methods

We performed a randomized, triple-blind, placebo-controlled clinical trial among 76 overweight or obese postmenopausal women with a history of hormone-receptor-positive BC. Participants were randomly divided into 2 groups to intake either 109 CFU/day synbiotic supplement or placebo (n = 38 each group) for 8 weeks. All participants were given a low-calorie diet program. The primary outcome was serum concentration of adiponectin which was measured at baseline and after 8 weeks.

Results

Compared with the placebo, synbiotic intake significantly increased adiponectin (+ 13.58 (10.08, 18.17) vs. − 0.42 (− 2.90, 1.98) μg/ml; P < 0.001). In addition, synbiotic supplementation resulted in significant reduction in TNF-α levels (− 17.09 (− 32.05, − 13.60) vs. 0.20 (− 3.97, 2.00) ng/L; P < 0.001) and hs-CRP levels (− 1.14 (− 1.90, − 0.88 vs. − 0.06 (− 0.38, 0.15) mg/L; P < 0.001) compared with the placebo.

Conclusions

In conclusion, 8-week synbiotic consumption by overweight and obese postmenopausal BCSs had beneficial effects on adiponectin, TNF-α, and hs-CRP.

Trial registration

IRCT, IRCT20091114002709N49. Registered 18 May 2018, http://www.irct.ir: IRCT20091114002709N49

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgments

We would like to gratefully thank the participants for their support in the study. We are also thankful for Zist Takhmir Company. We thank Nilou laboratory for the biochemical analysis of this project.

Funding

This study was supported by Iran University of Medical Sciences (IUMS), Tehran, Iran. No: IR.IUMS.REC1397.32557.

Author information

Authors and Affiliations

  1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

    Mahsa Raji Lahiji, Mitra Zarrati, Elhameh Cheshmazar & Farzad Shidfar

  2. Breast Disease Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

    Safa Najafi

  3. Department of Microbiology, School of Biology Sciences, Islamic Azad University, Tehran, Iran

    Bahareh Yazdani

  4. Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

    Elham Razmpoosh

  5. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Elham Razmpoosh

  6. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

    Leila Janani

  7. School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

    Mahtab Raji Lahiji

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  1. Mahsa Raji Lahiji
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Contributions

Farzad Shidfar, Mahsa Raji Lahiji, Mitra Zarrati, and Safa Najafi contributed in the conception, data collection, and manuscript drafting. Bahare Yazdani, Elhameh Cheshmazar, Elham Razmpoosh, and Leila Janani were involved in laboratory testing and analysis, statistical analysis, and manuscript writing. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Farzad Shidfar.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

All procedures performed in this study were in accordance with the ethical standards of the Iranian clinical trial (http://www.irct.ir: IRCT20091114002709N49) and with the 1964 Helsinki Declaration and Good Clinical Practice guidelines. The study was approved by The Iran University of Medical Science Ethical Committee (IR.IUMS.REC1397.32557).

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Informed consent was obtained from all individual participants included in the study.

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Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.

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Raji Lahiji, M., Zarrati, M., Najafi, S. et al. Effects of synbiotic supplementation on serum adiponectin and inflammation status of overweight and obese breast cancer survivors: a randomized, triple-blind, placebo-controlled trial. Support Care Cancer 29, 4147–4157 (2021). https://doi.org/10.1007/s00520-020-05926-8

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  • DOI: https://doi.org/10.1007/s00520-020-05926-8

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