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Termination of pregnancy for renal malformations

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Abstract

Background

We studied the correlation between prenatal diagnosis and postmortem investigations in pregnancies terminated for renal malformations.

Methods

Over a 5-year period, 77 cases of termination of pregnancy (TOP) for renal malformations were reviewed. Chromosomal anomalies (n = 9) and cases without conventional or virtual autopsy were excluded (n = 15). In 53 cases, prenatal ultrasound diagnosis and conventional autopsy findings were compared. In addition, we compared the accuracy of conventional and virtual autopsy findings in 17 cases.

Results

Full agreement was observed in 60.4 % (32/53) of cases. In 26.4 % (14/53) of the cases, the presence of additional malformations did not alter the final diagnosis. However, in 11.3 % (6/53) the final diagnosis was adjusted because of major additional findings. One case showed a total disagreement. Conventional and virtual autopsy were in full agreement in 52.9 % (9/17). Postmortem magnetic resonance imaging (MRI) description and detection of malformations was less complete and failed to correctly diagnose 5/17 cases (29.4 %). In 17.6 % (3/17) of the cases, postmortem MRI revealed malformations not confirmed by conventional autopsy.

Conclusions

A high correlation between prenatal ultrasound and postmortem investigations was observed. Conventional autopsy remains the gold standard to reveal additional major and minor malformations, leading to a correct final diagnosis. The added value of virtual necropsy for renal pathology was limited.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, University Hospitals Gasthuisberg - KU Leuven, Herestraat 49, 3000, Leuven, Belgium

    Eva Simoens, An Hindryckx & Luc De Catte

  2. Department of Pathology, University Hospitals Gasthuisberg - KU Leuven, Herestraat 49, 3000, Leuven, Belgium

    Philippe Moerman

  3. Department of Radiology, OLV Ziekenhuis, Moorselbaan 164, 9300, Aalst, Belgium

    Filip Claus

Authors
  1. Eva Simoens
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  2. An Hindryckx
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  3. Philippe Moerman
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  4. Filip Claus
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  5. Luc De Catte
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Corresponding author

Correspondence to Luc De Catte.

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Simoens, E., Hindryckx, A., Moerman, P. et al. Termination of pregnancy for renal malformations. Pediatr Nephrol 30, 1443–1449 (2015). https://doi.org/10.1007/s00467-015-3085-7

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  • DOI: https://doi.org/10.1007/s00467-015-3085-7

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