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Recreating kidney progenitors from pluripotent cells

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Abstract

Access to human pluripotent cells theoretically provides a renewable source of cells that can give rise to any required cell type for use in cellular therapy or bioengineering. However, successfully directing this differentiation remains challenging for most desired endpoints cell type, including renal cells. This challenge is compounded by the difficulty in identifying the required cell type in vitro and the multitude of renal cell types required to build a kidney. Here we review our understanding of how the embryo goes about specifying the cells of the kidney and the progress to date in adapting this knowledge for the recreation of nephron progenitors and their mature derivatives from pluripotent cells.

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Acknowledgments

ML is a Senior Principal Research Fellow of the National Health and Medical Research Council of Australia. BM is a Rosamond Siemon Postgraduate Scholar. This work is supported by Stem Cells Australia (Australian Research Council SRI110001002) and the National Health and Medical Research Council (APP1041277).

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  1. Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia

    Minoru Takasato, Barbara Maier & Melissa H. Little

  2. Institute for Molecular Bioscience, The University of Queensland, St. Lucia, 4072, Australia

    Melissa H. Little

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  2. Barbara Maier
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Correspondence to Melissa H. Little.

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Takasato, M., Maier, B. & Little, M.H. Recreating kidney progenitors from pluripotent cells. Pediatr Nephrol 29, 543–552 (2014). https://doi.org/10.1007/s00467-013-2592-7

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