Abstract
Background
Portomesenteric vein thrombosis following laparoscopic bariatric surgical procedures is a serious and potentially lethal complication. It is quite rare, and its clinical presentation, management, and sequelae remain poorly understood.
Methods
We searched PubMed, Medline, Google Scholar, Ovid, and Cochrane databases for articles reporting case series and systematic reviews in the English language on patients who underwent laparoscopic bariatric surgery and had a subsequent portal or mesenteric vein thrombosis. Articles discussing laparoscopic gastric banding were excluded.
Results
A total of 14 articles reporting on 36 cases were found. We analyzed the pooled data from these case reports and series with emphasis on number of reported patients, demographics, time of diagnosis, risk factors, symptoms, management, complications, and sequelae.
Conclusions
Portomesenteric vein thrombosis is not uncommon following laparoscopic bariatric surgery and appears to occur more after laparoscopic sleeve gastrectomy. Bariatric surgeons should have a high index of suspicion for early detection and treatment of this potentially lethal complication. Obese patients at high risk for venous thrombosis should be screened for genetic predisposition for hypercoagulable state and should be considered for extended thromboprophylaxis postoperatively.
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References
Colquitt JL, Pickett K, Loveman E, Frampton GK (2014) Surgery for weight loss in adults. Cochrane Database Syst Rev. doi:10.1002/14651858.CD003641.pub4
Buchwald H, Estok R, Fahrbach K, Banel D, Jensen MD, Pories WJ, Bantle JP, Sledge I (2009) Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 122:248–256
Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, Lamonte MJ, Stroup AM, Hunt SC (2007) Long-term mortality after gastric bypass surgery. N Engl J Med 357:753–761
Dakur Aridi H, Alami R, Tamim H, Shamseddine G, Fouani T, Safadi B (2015) Long-term outcomes of laparoscopic sleeve gastrectomy: a Lebanese center experience. Surg Obes Relat Dis. doi:10.1016/j.soard.2015.11.025
Longitudinal Assessment of Bariatric Surgery (LABS) Consortium, Flum DR, Belle SH, King WC, Wahed AS, Berk P, Chapman W, Pories W, Courcoulas A, McCloskey C, Mitchell J, Patterson E, Pomp A, Staten MA, Yanovski SZ, Thirlby R, Wolfe B (2009) Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med 361(5):445–454
Encinosa WE, Bernard DM, Du D, Steiner CA (2009) Recent improvements in bariatric surgery outcomes. Med Care 47(5):531–535
Noh KW, Wolfsen HC, Bridges MD, Hinder RA (2007) Mesenteric vein thrombosis after laparoscopic anti reflux surgery. Dig Dis Sci 52(1):273–275
Berthet B, Bollon E, Valero R, Ouaissi M, Sielezneff I, Sastre B (2009) Portal vein thrombosis due to factor 2 Leiden in the post-operative course of laparoscopic sleeve gastrectomy for morbid obesity. Obes Surg 19:1464–1467
Jakimowicz J, Stultiens G, Smulder F (1998) Laparoscopic insufflation of the abdomen reduces portal venous flow. Surg Laparosc Endosc 12:129–132
James AW, Rabl C, Westphalen AC, Fogarty PF, Posselt AM, Campos GM (2009) Portomesenteric venous thrombosis after laparoscopic surgery: a systematic literature review. Arch Surg 144(6):520–526
Kaleya RN, Boley SJ (1989) Mesenteric venous thrombosis. In: Delaney JP, Najarian JS (eds) Progress in gastrointestinal surgery. Year Book Medical, Chicago, pp 417–425
Salinas J, Barros D, Salgado N, Viscido G, Funke R, Pérez G, Pimentel F, Boza C (2014) Portomesenteric vein thrombosis after laparoscopic sleeve gastrectomy. Surg Endosc 28:1083–1089
Stroh C, Köckerling F, Volker L, Frank B, Stefanie W, Christian K, Christiane B, Thomas M; Obesity Surgery Working Group, Competence Network Obesity (2015) Results of more than 11,800 sleeve gastrectomies: data analysis of the german bariatric surgery registry. Ann Surg, Dec 31 (Epub ahead of print)
Rosenthal RJ, International Sleeve Gastrectomy Expert Panel, Diaz AA, Arvidsson D, Baker RS, Basso N, Bellanger D, Boza C, El Mourad H, France M, Gagner M, Galvao-Neto M, Higa KD, Himpens J, Hutchinson CM, Jacobs M, Jorgensen JO, Jossart G, Lakdawala M, Nguyen NT, Nocca D, Prager G, Pomp A, Ramos AC, Rosenthal RJ, Shah S, Vix M, Wittgrove A, Zundel N (2012) International sleeve gastrectomy expert panel consensus statement: best practice guidelines based on experience of > 12,000 cases. Surg Obes Relat Dis 8:8–19
Higa DK, Boone BK, Ho T (2000) Complications of the laparoscopic Roux-en-Y gastric bypass: 1,040 patients—What we have learned? Obes Surg 10(6):509–513
Farías C, Fernández JI, Ovalle C, Cabrera C, de la Maza J, Kosiel K, Molina AM (2013) Transumbilical sleeve gastrectomy with an accessory lateral port: surgical results in 237 patients and 1-year follow-up. Obes Surg 23:325–331
Young TM, Gebhart A, Phelan JM, Nguyen TN (2015) Use and outcomes of laparoscopic sleeve gastrectomy vs laparoscopic gastric bypass: analysis of the American College of Surgeons NSQIP. J Am Coll Surg 220(5):880–885
Takagi S (1998) Hepatic and portal vein blood flow during carbon dioxide pneumoperitoneum for laparoscopic hepatectomy. Surg Endosc 12(5):427–431
Haglund U, Norlen K, Rasmussen I et al (1995) Complications related to pneumoperitoneum. In: Baley RW, Flowers JL (eds) Complications of laparoscopic surgery. Quality Medical Publishing Inc, St. Louis, pp 45–48
Kotzampassi K, Kampanidis N, Nazamias P, Eleftheriadis E (1993) Hemodynamic events in the peritoneal environment during pneumoperitoneum in dogs. Surg Endosc 7(6):494–499
Ng M, Fleming T, Robinson M et al (2014) Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study. Lancet 384:766–781
Ueno N, Kawamura H, Takahashi H, Fujisawa N, Yoneda M, Kirikoshi H, Sakaguchi T, Saito S, Togo S (2006) Characterization of portal vein thrombus with the use of contrast-enhanced sonography. J Ultrasound Med 25(9):1147–1152
Rhee RY, Gloviczki P (1997) Mesenteric venous thrombosis. Surg Clin North Am 77:327–338
Subramanyan BR, Balthazar EJ, Lefleur RS, Horii SC, Hulnick DH (1984) Portal venous thrombosis: correlative analysis of sonography, CT and angiography. Am J Gastroenterol 79(10):773–776
Colaizzo D, Amitrano L, Tiscia GL, Scenna G, Grandone E, Guardascione MA, Brancaccio V, Maraglione M (2007) The JAK2 V617F mutation frequently occurs in patients with portal and mesenteric venous thrombosis. J Thromb Haemost 5:55–61
Riva N, Donadini MP, Dentali F, Squizzato A, Ageno W (2012) Clinical approach to the splanchnic vein thrombosis: risk factors and treatment. Thromb Res 130:S1–S3
Handa P, Crowther M, Douketis JD (2013) Portal vein thrombosis: a clinician-oriented and practical review. Clin App Thromb Hemost 20:498–506
Parikh S, Shah R, Kapoor P (2010) Portal vein thrombosis. Am J Med 123:111–119
Lang SA, Loss M, Wohlgemuth WA, Schlitt HJ (2014) Clinical management of acute portal/mesenteric vein thrombosis. Viszeralmedizin 30:394–400
Plessier A, Rautou PE, Valla DC (2012) Management of hepatic vascular diseases. J Hepatol 56(1):S25–S38
Bellanger ED, Hargroder GA, Greenway LF (2010) Mesenteric venous thrombosis after laparoscopic sleeve gastrectomy. Surg Obes Relat Dis 6:109–111
Denne LJ, Kowalsky C (2005) Portal vein thrombosis after laparoscopic gastric bypass. Obes Surg 15:886–889
Franco J, Del Castillo J, Velaquez A, Martinez J (2011) Portal thrombosis after laparoscopic bariatric surgery. Description of 3 cases and systematic literature review. BMI 1(2):1–5
Gandhi K, Singh P, Sharma M, Desai H, Nelson J, Kaul A (2010) Mesenteric vein thrombosis after laparoscopic gastric sleeve procedure. J Thromb 30:179–183
Hughes LD, Worrall JS, Khan H, Cochrane R (2014) Mesenteric ischaemia secondary to portomesenteric venous thrombosis, 2 weeks post laparoscopic sleeve gastrectomy in a cirrhotic patient. BMJ Case Rep. doi:10.1136/bcr-2013-202246
Keung HC, Gander WJ, Zitsman LJ (2015) Mesenteric venous thrombosis following vertical sleeve gastrectomy in an adolescent. Surg Obes Relat Dis 11:e23–e26
Lopez R, Flint R (2013) Portal vein thrombosis as a complication of laparoscopic sleeve gastrectomy. NZMJ 126:103–105
Pigeyre M, Seguy D, Arnalsteen L, Patton F, Romon M (2008) Laparoscopic gastric bypass complicated by portal venous thrombosis and severe neurological complications. Obes Surg 18:1203–1207
Pineda L, Sarhan M, Ahmed L (2013) Superior mesenteric vein thrombosis after laparoscopic sleeve gastrectomy. Surg Laparosc Percutan Tech 23(4):e162–e163
Rosenberg MJ, Tedesco M, Yao D, Eisenberg D (2010) Portal vein thrombosis following laparoscopic sleeve gastrectomy for morbid obesity. JSLS 16:639–643
Singh P, Sharma M, Gandhi K, Nelson J, Kaul A (2010) Acute mesenteric vein thrombosis after laparoscopic gastric sleeve gastrectomy for morbid obesity. Surg Obes Relat Dis 6:107–108
Swartz DE, Felix EL (2004) Acute mesenteric venous thrombosis following laparoscopic Roux-en-Y gastric bypass. J Soc Laparosc Surg 8:165–169
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Mustapha A. el Lakis, Agostino Pozzi, Jad Chamieh, and Bassem Safadi have no conflicts of interest or financial ties to disclose.
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el Lakis, M.A., Pozzi, A., Chamieh, J. et al. Portomesenteric vein thrombosis after laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass: a 36-case series. Surg Endosc 31, 1005–1011 (2017). https://doi.org/10.1007/s00464-016-5078-4
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DOI: https://doi.org/10.1007/s00464-016-5078-4