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The effect of different intraabdominal pressures on lipid peroxidation and protein oxidation status during laparoscopic cholecystectomy

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Abstract

Background: This prospective, randomized, and controlled study was designed to investigate the effects of different intraabdominal pressures (IAPs) on lipid peroxidation and protein oxidation status during laparoscopic cholecystectomy (LC). Methods: Twenty-four patients (12 men, 12 women) who underwent LC at either 10 or 15 mmHg of IAP were randomized into two groups. Repeated blood samples were collected to measure thiobarbituric acid reactive substances (TBARS) levels to assess lipid peroxidation and protein carbonyl content and protein sulfhydryl groups to assess protein oxidation status. Results: Serum protein carbonyls and TBARS levels were found to be increased immediately after desufflation in both study groups when compared to the preoperative levels. On the other hand, protein sulfhydryl levels were found to be decreased in both study groups. Although increases in protein carbonyls and TBARS levels were more prominent in patients who underwent LC at 15 mmHg of IAP, this difference was not statistically significant between both groups. Conclusions: The results suggest that both 15 and 10 mmHg of LAP could lead to an increased oxidative stress response during LC, but no difference was found between the groups.

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References

  1. DJ Cullen JP Coyle R Teplick MC Long (1989) ArticleTitleCardiovascular, pulmonary, and renal effects massively increased intra-abdominal pressure in critically ill patients. Crit Care 17 118–121 Occurrence Handle1:STN:280:BiaC38%2FhsVM%3D Occurrence Handle2914444

    CAS  PubMed  Google Scholar 

  2. LN Diebel SA Dulchavsky WJ Brown (1996) ArticleTitleSplanchnic ischemia and bacterial translocation in abdominal compartment syndrome. J Trauma 40 178

    Google Scholar 

  3. LN Diebel SA Dulchavsky RF Wilson (1992) ArticleTitleEffect of increased mesenteric arterial and intestinal mucosal blood flow. J Trauma 33 45–49 Occurrence Handle1:STN:280:By2A2c7ktVM%3D Occurrence Handle1635105

    CAS  PubMed  Google Scholar 

  4. LN Diebel RF Wilson SA Dulchavsky J Saxe (1992) ArticleTitleEffect of increased intraabdominal pressure on hepatic arterial, portal venous, and hepatic microcirculatory blood flow. J Trauma 33 279–283 Occurrence Handle1:STN:280:By2A2szotlw%3D Occurrence Handle1507294

    CAS  PubMed  Google Scholar 

  5. E Eleftheriadis K Kotzampassi K Papanotas N Heliadis K Sarris (1996) ArticleTitleGut ischemia, oxidative stress and bacterial translocation in elevated abdominal pressure in rats. World J Surg 20 11–16 Occurrence Handle10.1007/s002689900002 Occurrence Handle1:STN:280:BymC2cfjsVE%3D Occurrence Handle8588401

    Article  CAS  PubMed  Google Scholar 

  6. E Eleftheriadis K Kotzampasi (1998) Influence of pneumoperitoneum on the mesenteric circulation. RJ Rosenthal RL Friedman EH Phillips (Eds) The pathophysiology of pnemoperitoneum Springer Berlin 49–61

    Google Scholar 

  7. I Gal E Roth J Lantos G Varga MT Jaberansari (1997) ArticleTitleInflammatory mediators and surgical trauma regarding laparoscopic access: free radical mediated reactions. Acta Chir Hung 36 97–99 Occurrence Handle1:STN:280:DyaK1c%2Fnt1GrsA%3D%3D Occurrence Handle9408302

    CAS  PubMed  Google Scholar 

  8. GK Glantzounis AD Tselepis AP Tambaki TA Trikalinos AD Manataki DA Galaris EC Tsimoyiannis AM Kappas (2001) ArticleTitleLaparoscopic surgery-induced changes in oxidative stress markers in human plasma. Surg Endosc 15 1315–1319 Occurrence Handle1:STN:280:DC%2BD3MnotV2ksw%3D%3D Occurrence Handle11727142

    CAS  PubMed  Google Scholar 

  9. J Jakimowicz G Stultiens F Smulders (1998) ArticleTitleLaparoscopic insufflation of the abdomen reduces portal venous flow. Surg Endosc 12 129–132 Occurrence Handle10.1007/s004649900612 Occurrence Handle1:STN:280:DyaK1c7ktVemsQ%3D%3D Occurrence Handle9479726

    Article  CAS  PubMed  Google Scholar 

  10. T Koken M Serteser A Kahraman C Gokce (2002) ArticleTitleOxidative stress markers in hepatitis C infected hemodialysis patients. J Nephrol 15 302–307 Occurrence Handle1:CAS:528:DC%2BD38Xpsleitbk%3D Occurrence Handle12113603

    CAS  PubMed  Google Scholar 

  11. JF Koster P Biemond AJ Swaak (1986) ArticleTitleIntracellular and extracellular sulfhydryl levels in rheumatoid artritis. Ann Rheum Dis 45 44–46 Occurrence Handle1:CAS:528:DyaL28Xos1Chug%3D%3D Occurrence Handle3954457

    CAS  PubMed  Google Scholar 

  12. RL Levine D Garland CN Oliver A Amici I Climent A Lenz BW Ahn S Shaltiel ER Stadtman (1990) ArticleTitleDetermination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186 464–478 Occurrence Handle1:CAS:528:DyaK3MXksVGhtLY%3D Occurrence Handle1978225

    CAS  PubMed  Google Scholar 

  13. H Okhawa N Ohishi K Yagi (1979) ArticleTitleAssay for lipid peroxidase in animal tissues by thiobarbituric acid reaction. Anal Biochem 95 351–358 Occurrence Handle1:CAS:528:DyaE1MXksFaisbk%3D Occurrence Handle36810

    CAS  PubMed  Google Scholar 

  14. MM Ozmen A Aslar . Kessaf HT Besler I Cinel (2002) ArticleTitleDoes splanchnic ischemia occur during laparoscopic cholecystectomy? Surg Endosc 16 468–472 Occurrence Handle10.1007/s00464-001-9031-8 Occurrence Handle1:STN:280:DC%2BD387psFShtA%3D%3D Occurrence Handle11928030

    Article  CAS  PubMed  Google Scholar 

  15. C Polat Y Arıkan C Vatansev G Akbulut S Yılmaz FH Dilek Ö Gökçe (2002) ArticleTitleThe effects of increased intraabdominal pressure on the colonic anastomoses. Surg Endosc 16 1314–1319 Occurrence Handle1:STN:280:DC%2BD38vntlGqtg%3D%3D Occurrence Handle11988804

    CAS  PubMed  Google Scholar 

  16. MK Schilling C Redaelli L Krahenbühl C Signer M Büchler (1997) ArticleTitleSplanchnic microcirculatory changes during CO2 laparoscopy. J Am Coll Surg 184 378–382 Occurrence Handle1:STN:280:ByiB2MrjtlI%3D Occurrence Handle9100683

    CAS  PubMed  Google Scholar 

  17. R Seven A Seven Y Erbil S Mercan G Burcak (1999) ArticleTitleLipid peroxidation and antioxidant state after laparoscopic and open cholecystectomy. Eur J Surg 165 871–874 Occurrence Handle10.1080/11024159950189384 Occurrence Handle1:STN:280:DC%2BD3c%2FgtFegsw%3D%3D Occurrence Handle10533764

    Article  CAS  PubMed  Google Scholar 

  18. S Yilmaz E Ates C Polat T Koken C Tokyol G Akbulut O Gokce (2002) ArticleTitlePreconditioning decreases laparoscopy-induced oxidative stress in small intestine. Hepato-Gastroenterology

    Google Scholar 

  19. S Yilmaz T Koken C Tokyol A Kahraman G Akbulut M Serteser C Polat C Gokce O Gokce (2002) ArticleTitleCan preconditioning reduce laparoscopy-induced tissue injury. Surg Endosc Occurrence Handle1:STN:280:DC%2BD387psFSjug%3D%3D Occurrence Handle11928012

    CAS  PubMed  Google Scholar 

  20. B Zulfikaroglu M Koc A Soran FK Isman I Cinel (2002) ArticleTitleEvaluation of oxidative stress in laparoscopic cholecystectomy. Surg Today 32 869–874 Occurrence Handle10.1007/s005950200169 Occurrence Handle1:CAS:528:DC%2BD38XnvVSgsbo%3D Occurrence Handle12376782

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of General Surgery, Faculty of Medicine, Afyon Kocatepe University, Afyon , Turkey

    C. Polat, S. Yilmaz & O. N. Dilek

  2. Department of Biochemistry, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey

    M. Serteser, T. Koken & A. Kahraman

Authors
  1. C. Polat
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  2. S. Yilmaz
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  3. M. Serteser
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  4. T. Koken
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  5. A. Kahraman
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  6. O. N. Dilek
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Correspondence to C. Polat.

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Polat, C., Yilmaz, S., Serteser, M. et al. The effect of different intraabdominal pressures on lipid peroxidation and protein oxidation status during laparoscopic cholecystectomy . Surg Endosc 17, 1719–1722 (2003). https://doi.org/10.1007/s00464-002-9258-z

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  • DOI: https://doi.org/10.1007/s00464-002-9258-z

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