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Cell-based therapies for neonatal lung disease

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Abstract

Preterm birth occurs in approximately 11 % of all births worldwide. Advances in perinatal care have enabled the survival of preterm infants born as early as 23–24 weeks of gestation. However, many are affected by bronchopulmonary dysplasia (BPD)—a common respiratory complication of preterm birth, which has life-long consequences for lung health. Currently, there is no specific treatment for BPD. Recent advances in stem cell research have opened new therapeutic avenues for prevention/repair of lung damage. This review summarizes recent pre-clinical data and early clinical translation of cell-based therapies for BPD.

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Authors and Affiliations

  1. Department of Physiology and Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada, T6G 2E1

    Megan O’Reilly

  2. Sinclair Centre for Regenerative Medicine and Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, K1H 8L6

    Bernard Thébaud

  3. Division of Neonatology, Department of Pediatrics, Children’s Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, 401 Smyth Road, Ottawa, ON, Canada, K1H 5B2

    Bernard Thébaud

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  1. Megan O’Reilly
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  2. Bernard Thébaud
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Correspondence to Bernard Thébaud.

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O’Reilly, M., Thébaud, B. Cell-based therapies for neonatal lung disease. Cell Tissue Res 367, 737–745 (2017). https://doi.org/10.1007/s00441-016-2517-4

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