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Regulation of septation: a novel role for SerC/PdxF in Salmonella?

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Abstract

The sfiW locus of Salmonella enterica, previously identified by mutations that suppress the cell division defect of His-constitutive (Hisc) strains, corresponds to serC, the bifunctional gene for phosphoserine-oxoglutarate aminotransferase (SerC) and 2-ketoerythroic acid 4-phosphate transaminase (PdxF). SerC- mutants form small, nearly spherical cells in a wild-type (His+) background, suggesting that the SerC/PdxF product acts as a septation antagonist. Suppression of Hisc filamentation by serC mutations may be explained by loss of the anti-septation activity of SerC/PdxF. The isolation of serC alleles that have lost their biosynthetic activities but are still able to inhibit septum formation suggests that the anti-septation activity of the SerC/PdxF product is unrelated to its known roles in serine and pyridoxine biosynthesis.

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Authors and Affiliations

  1. Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, Sevilla 41080, Spain

    C. Mouslim, D. A. Cano, A. Flores & J. Casadesús

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  1. C. Mouslim
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  2. D. A. Cano
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  3. A. Flores
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  4. J. Casadesús
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Mouslim, C., Cano, D., Flores, A. et al. Regulation of septation: a novel role for SerC/PdxF in Salmonella?. Mol Gen Genet 264, 184–192 (2000). https://doi.org/10.1007/s004380000311

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  • DOI: https://doi.org/10.1007/s004380000311

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