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The effects of CXCL10 polymorphisms on COPD susceptibility

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Abstract

The polymorphisms of cytokine genes has been reported to modulate the individual’s susceptibility to environmental stimuli in COPD development. C–X–C motif chemokine 10 (CXCL10) mediates recruitment inflammatory cells such as monocytes. Therefore, it may play a key role in COPD. Here, a case–control study was conducted to evaluate the association between CXCL10 tag-SNPs and COPD risk. Four tag-SNPs including rs4256246, rs4508917, rs56061981, and rs56316945 were identified based on the linkage disequilibrium (LD) analysis in 30 healthy controls. The associations between these four tag-SNPs and COPD risk were further evaluated in 480 COPD cases and 488 controls. We found that the “T” allele of rs56061981 was significantly associated with reducing risk of COPD, while “G” allele of rs56316945 was significantly associated with increasing risk of COPD. SNP rs56316945 was significantly associated with increasing risk of COPD under different models except recessive model after adjusting the sex, age, pack year, and biomass. SNP rs56061981 was significantly associated with decreasing COPD risk under different models except recessive model after adjusting the sex, age, pack year, and biomass. Stratified analysis of smoking status and biomass with SNPs supported rs56061981 may interact with biomass and smoking thus modulate COPD susceptibility and rs56216945 was apparently associated with the severity of pulmonary function of COPD patients. This study suggests that rs56061981 and rs56216945 in CXCL10 gene promoter contribute COPD susceptibility.

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Author notes

  1. Yan Wang, Qipeng Zhou, Lian Dong, and Mingmei Xiong contributed equally to this article.

Authors and Affiliations

  1. State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, Guangdong, China

    Yan Wang, Qipeng Zhou, Lian Dong, Mingmei Xiong, Hua Jiang, Meihua Guo, Li Zhao, Liang Yuan, Ziying Li, Hanwei Liu, Jian Wang, Nanshan Zhong & Wenju Lu

Authors
  1. Yan Wang
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  2. Qipeng Zhou
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  3. Lian Dong
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  4. Mingmei Xiong
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  5. Hua Jiang
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  7. Li Zhao
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  8. Liang Yuan
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  9. Ziying Li
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  10. Hanwei Liu
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  11. Jian Wang
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  13. Wenju Lu
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Corresponding author

Correspondence to Wenju Lu.

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Funding

This study was funded by National Precision Medicine Foundation (No. 2016YFC0903700).

Conflict of interest

All the authors declare that they have no conflict of interest. We are grateful to the COPD patients and control subjects for their participation in this study. We also thank the clinicians and hospital staff who contributed to the sample and data collection.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Committee of The First Affiliated Hospital (GZMC2009-08-1336).

Additional information

Communicated by S. Hohmann.

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Wang, Y., Zhou, Q., Dong, L. et al. The effects of CXCL10 polymorphisms on COPD susceptibility. Mol Genet Genomics 293, 649–655 (2018). https://doi.org/10.1007/s00438-017-1408-z

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  • DOI: https://doi.org/10.1007/s00438-017-1408-z

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