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Ivermectin treatment of bovine psoroptic mange: effects on serum chemistry, hematology, organ weights, and leather quality

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Abstract

Psoroptic mange is a skin disease which may result in serious health and welfare problems and important economic losses. Apart from the effect on weight gain, little information is available concerning other responses of the organism consequent to the successful therapy of bovine psoroptic mange. Accordingly, serum chemistry, hematology, organ weights, and leather quality of young bulls with experimentally induced clinical Psoroptes ovis mange and treated with either ivermectin long-acting injection (IVM LAI; IVOMEC® GOLD, Merial) or saline (n = 16 each) were examined 8 weeks after treatment when all IVM LAI-treated bulls were free of live P. ovis mites while the saline-treated bulls maintained clinical mange. IVM LAI-treated bulls had higher (p < 0.05) alkaline phosphatase, creatinine, cholesterol, glucose, and albumin levels and lower (p < 0.01) total protein and β- and γ-globulin levels than the saline-treated bulls. Complete blood counts revealed higher leukocyte counts associated with higher eosinophil counts and higher platelet counts in the saline-treated compared to the IVM LAI-treated bulls (p < 0.01). Correlating with body weight, the warm carcass weight of the saline-treated bulls was lower than that of the IVM LAI-treated bulls (p < 0.05). Absolute and relative (organ weight divided by body weight) weights of the spleen, thymus, omental fat, and perirenal fat were higher (p < 0.01) for the IVM LAI-treated bulls than for the saline-treated bulls, while the IVM LAI-treated bulls had lower (p < 0.05) absolute and relative weights of the liver, adrenal glands, and selected lymph nodes than the saline-treated bulls. The leathers produced from the IVM LAI-treated bulls showed significantly (p < 0.001) less severe gouging or etching than leathers from the saline-treated bulls, and significantly (p < 0.05) more leather from the IVM LAI-treated bulls was of usable quality than the size of leather from the saline-treated bulls. Overall, these findings provided evidence that many changes, which are indicative of impaired protein and energy metabolism, immune system function, and performance resultant from clinical psoroptic mange, improved substantially within 8 weeks of successful treatment with injectable ivermectin.

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Authors and Affiliations

  1. Merial GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101, Rohrdorf, Germany

    S. Rehbein & M. Visser

  2. Forschungsinstitut für Leder und Kunststoffbahnen gGmbH, Meißner Ring 1-5, 09599, Freiberg, Germany

    M. Meyer

  3. IDT Biologika GmbH, Am Pharmapark, 06861, Dessau-Roßlau, Germany

    T. Lindner

Authors
  1. S. Rehbein
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  2. M. Visser
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  3. M. Meyer
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  4. T. Lindner
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Correspondence to S. Rehbein.

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Animals were handled and treated with due regard for their welfare and in compliance with Merial Institutional Animal Care and Use Committee approvals and applicable local regulations.

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The work reported herein was funded by Merial, Inc., GA, USA. All authors are current employees or were contractors of Merial.

IVOMEC® is a registered trademark of Merial. All other marks are the property of their respective owners.

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Rehbein, S., Visser, M., Meyer, M. et al. Ivermectin treatment of bovine psoroptic mange: effects on serum chemistry, hematology, organ weights, and leather quality. Parasitol Res 115, 1519–1528 (2016). https://doi.org/10.1007/s00436-015-4885-1

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  • DOI: https://doi.org/10.1007/s00436-015-4885-1

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